Thottapalayam virus is genetically distant to the rodent-borne hantaviruses, consistent with its isolation from the Asian house shrew (Suncus murinus)

Thottapalayam (TPM) virus belongs to the genus Hantavirus, family Bunyaviridae. The genomes of hantaviruses consist of three negative-stranded RNA segments (S, M and L) encoding the virus nucleocapsid (N), glycoprotein (Gn, Gc), and polymerase (L) proteins, respectively. The genus Hantavirus contains predominantly rodent-borne viruses, with the prominent exception of TPM virus which was isolated in India in 1964 from an insectivore, Suncus murinus, commonly referred to as the Asian house shrew or brown musk shrew. Analysis of the available TPM virus S (1530 nt) RNA genome segment sequence and the newly derived M (3621 nt) and L (6581 nt) segment sequences demonstrate that the entire TPM virus genome is very unique. Remarkably high sequence differences are seen at the nucleotide (up to S – 47%, M – 49%, L – 38%) and protein (up to N – 54%, Gn/Gc – 57% and L – 39%) levels relative to the rodent-borne hantaviruses, consistent with TPM virus having a unique host association

Clustering Analyses of 300,000 Photometrically Classified Quasars--II. The Excess on Very Small Scales

We study quasar clustering on small scales, modeling clustering amplitudes using halo-driven dark matter descriptions. From 91 pairs on scales <35 kpc/h, we detect only a slight excess in quasar clustering over our best-fit large-scale model. Integrated across all redshifts, the implied quasar bias is b_Q = 4.21+/-0.98 (b_Q = 3.93+/-0.71) at ~18 kpc/h (~28 kpc/h). Our best-fit (real-space) power index is ~-2 (i.e., $\xi(r) \propto r^{-2}$), implying steeper halo profiles than currently found in simulations. Alternatively, quasar binaries with separation <35 kpc/h may trace merging galaxies, with typical dynamical merger times t_d~(610+/-260)m^{-1/2} Myr/h, for quasars of host halo mass m x 10^{12} Msolar/h. We find UVX quasars at ~28 kpc/h cluster >5 times higher at z > 2, than at z < 2, at the $2.0\sigma$ level. However, as the space density of quasars declines as z increases, an excess of quasar binaries (over expectation) at z > 2 could be consistent with reduced merger rates at z > 2 for the galaxies forming UVX quasars. Comparing our clustering at ~28 kpc/h to a \xi(r)=(r/4.8\Mpch)^{-1.53} power-law, we find an upper limit on any excess of a factor of 4.3+/-1.3, which, noting some caveats, differs from large excesses recently measured for binary quasars, at $2.2\sigma$. We speculate that binary quasar surveys that are biased to z > 2 may find inflated clustering excesses when compared to models fit at z < 2. We provide details of 111 photometrically classified quasar pairs with separations <0.1'. Spectroscopy of these pairs could significantly constrain quasar dynamics in merging galaxies.Comment: 12pages, 3 figures, 2 tables; uses amulateapj; accepted to Ap

High-rate, high-fidelity entanglement of qubits across an elementary quantum network

We demonstrate remote entanglement of trapped-ion qubits via a quantum-optical fiber link with fidelity and rate approaching those of local operations. Two ${}^{88}$Sr${}^{+}$ qubits are entangled via the polarization degree of freedom of two photons which are coupled by high-numerical-aperture lenses into single-mode optical fibers and interfere on a beamsplitter. A novel geometry allows high-efficiency photon collection while maintaining unit fidelity for ion-photon entanglement. We generate remote Bell pairs with fidelity $F=0.940(5)$ at an average rate $182\,\mathrm{s}^{-1}$ (success probability $2.18\times10^{-4}$).Comment: v2 updated to include responses to reviewers, as published in PR

Oliveros Virus: A Novel Arenavirus from Argentina

AbstractDuring the past few decades several newly recognized rodent-borne arenaviruses have been shown to be associated with severe hemorrhagic fever cases in South America. Changes in ecology and farming practices throughout the region have increased the concern over the potential public health threat posed by such emerging virus diseases. Oliveros (OLV) virus is a recently discovered arenavirus of the rodentBolomys obscurusin Argentina. Genetic analysis of the small genomic RNA segment, which encodes the nucleocapsid protein and the envelope glycoproteins, shows that Oliveros is a novel, phylogenetically distinct member of theArenaviridaefamily which differs in nucleotide sequence from the previously characterized members by approximately 35% or more. Despite this level of diversity, OLV virus possesses the same ambisense genome structure and many overall RNA and protein features in common with other arenaviruses. These data represent an important first step in the development of specific immunological and PCR diagnostic reagents to allow assessment of the prevalence and disease potential of this virus

The Angular Power Spectrum of EDSGC Galaxies

We determine the angular power spectrum, C_l, of the Edinburgh/Durham Southern Galaxy Catalog (EDSGC) and use this statistic to constrain cosmological parameters. Our methods for determining C_l, and the parameters that affect it are based on those developed for the analysis of cosmic microwave background maps. We expect them to be useful for future surveys. Assuming flat cold dark matter models with a cosmological constant (constrained by COBE/DMR and local cluster abundances), and a scale--independent bias, b, we find good fits to the EDSGC angular power spectrum with 1.11 < b < 2.35 and 0.2 < Omega_m < 0.55 at 95% confidence. These results are not significantly affected by the ``integral constraint'' or extinction by interstellar dust, but may be by our assumption of Gaussianity.Comment: 11 pages, 9 figures, version to appear in Ap

GMOS Integral Field Spectroscopy of a Merging System with Enhanced Balmer Absorption

In this paper we present the three dimensional dynamics of the galaxy SDSS J101345.39+011613.66, selected for its unusually strong Balmer absorption lines (Wo(H-delta)=7.5A). Using the GMOS-South IFU in Nod & Shuffle mode we have mapped the continuum and optical absorption lines of this z=0.1055 field galaxy. This galaxy has a disturbed morphology, with a halo of diffuse material distributed asymmetrically toward the north. Using the [OII] emission line (Wo([OII])=4.1A) we find that the gas and hot OB stars are offset from the older stars in the system. The gas also has a spatially extended and elongated morphology with a velocity gradient of 100+/-20km/s across 6kpc in projection. Using the strong H-gamma and H-delta absorption lines we find that the A- stars are widely distributed across the system and are not centrally concentrated arguing that the A-star population has formed in molecular clouds outside the nucleus. By cross correlating the spectra from the datacube with an A-star template we find evidence that the A-star population has a 40km/s shear in the same direction as the gas. The disturbed morphology, strong colour gradients and strong H-delta and H-gamma absorption lines in SDSS J101345.39 argue that this is a recent tidal interaction/merger between a passive elliptical and star-forming galaxy. Although based on a single object, these results show that we can spatially resolve and constrain the dynamics of this short lived (yet important) phase of galaxy formation in which the evolutionary process take galaxies from star-forming to their quiescent end products.Comment: 7 pages, 7 figures. Accepted for publication in Ap

Clustering of loose groups and galaxies from the Perseus--Pisces Survey

We investigate the clustering properties of loose groups in the Perseus--Pisces redshift Survey (PPS). Previous analyses based on CfA and SSRS surveys led to apparently contradictory results. We investigate the source of such discrepancies, finding satisfactory explanations for them. Furthermore, we find a definite signal of group clustering, whose amplitude $A_G$ exceeds the amplitude $A_g$ of galaxy clustering ($A_G=14.5^{+3.8}_{-3.0}$, $A_g=7.42^{+0.20}_{-0.19}$ for the most significant case; distances are measured in \hMpc). Groups are identified with the adaptive Friends--Of--Friends (FOF) algorithms HG (Huchra \& Geller 1982) and NW (Nolthenius \& White 1987), systematically varying all search parameters. Correlation strenght is especially sensitive to the sky--link $D_L$ (increasing for stricter normalization $D_0$), and to the (depth \mlim of the) galaxy data. It is only moderately dependent on the galaxy luminosity function $\phi(L)$, while it is almost insensitive to the redshift--link $V_L$ (both to the normalization $V_0$ and to the scaling recipes HG or NW).Comment: 28 pages (LaTeX aasms4 style) + 5 Postscript figures ; ApJ submitted on May 4th, 1996; group catalogs available upon request ([email protected]

Analysis of linezolid and tigecycline as candidates for local prophylaxis via antibiotic-loaded bone cement

Objectives To assess the Gram-positive-specific antibiotic linezolid and the broad-spectrum antibiotic tigecycline for use in local antibiotic delivery via antibiotic-loaded bone cement. Methods Linezolid and tigecycline were added to Biomet bone cement at varying concentrations. Antibiotic elution over 1 week was quantified by HPLC-MS. The effect of wear on elution over 51 h was determined using a modified TE-66 wear tester. Eluted antibiotics were used to determine the MICs for a panel of clinically relevant bacteria. The impact strength of antibiotic-loaded samples was determined using a Charpy-type impact testing apparatus. Cytotoxicity of eluted antibiotics against MG-63 cells was evaluated using an MTT assay. Results Linezolid and tigecycline eluted from bone cement to clinically relevant levels within 1 h and retained activity over 1 week. Mechanical wear significantly reduced elution of tigecycline, but had little effect on elution of linezolid. Linezolid showed low cytotoxicity towards MG-63 cells with ≤300 mg/mL resulting in >50% cell activity. Cytotoxicity of tigecycline was higher, with an IC50 of 5–10 mg/L. Conclusions Linezolid and tigecycline retain activity after elution from bone cement. The concentration of tigecycline may need to be carefully controlled due to cytotoxicity. The effect of wear on bone cement may need to be considered if tigecycline is to be used for local delivery. Up to 10% linezolid can be added without affecting the impact strength of the bone cement. These results are promising indications for future investigation of these antibiotics for use in local antibiotic delivery strategies