Gut health in veterinary medicine: A bibliometric analysis of the literature

SIMPLE SUMMARY: Gut health has been a main topic in veterinary medicine research after the ban on the use of antimicrobial growth promoters. Gut health has been defined as absence/prevention/avoidance of gastrointestinal disease so that the animal is able to perform its physiological functions. A bibliometric analysis is a set of statistical methods used to explore trends in the scientific literature such as number of publications, most prolific countries and main research areas to highlight publication dynamics and gaps of knowledge. In this case, a bibliometric analysis was performed on veterinary gut health using the database Web of Science and the R package Bibliometrix. A total of 1696 documents were retrieved between 2000 and 2020, showing an increase of 22.4% in the number of annual publications. Pigs (34.8%), poultry (chicken, duck, turkey and quail—33.9%) and aquaculture (fishes, crustaceans and frog—15.0%) were the most studied species while a scarce number of publications was found on felines, cows, horses, rodents, goats and sheep. China (24.7%), USA (17.2%) and Canada (5.7%) were the most productive countries. Three main research lines aimed to explore animal nutrition, prevention of inflammatory diseases and microbiota composition were identified. This study will help drive future research on the topic. ABSTRACT: Gut health is a recent relevant research topic in veterinary medicine and it has been shown to be associated with better zootechnical performances and animal welfare. A bibliometric analysis was performed to explore publication trends, dynamics and possible knowledge gaps in this field in the last twenty years (2000–2020). The database Web of Science was searched and the results were analyzed by the R package Bibliometrix. A total of 1696 documents were retrieved in the evaluated period, showing a constant annual growth in the number of publications of 22.4%. These articles focused mainly on pigs (34.8%), poultry (chicken, duck, turkey and quail—33.9%) and aquaculture (fishes, crustaceans and frog—15.0%) while a scarce number was found on felines, cows, horses, rodents, goats and sheep. China was the most productive country (24.7%) followed by the USA (17.2%) and Canada (5.7%). Keyword’s analysis showed that the main research lines aimed to explore animal nutrition, prevention of inflammatory diseases and microbiota composition. This study shows a comprehensive bibliometric analysis of the evolution of veterinary gut health research that will help to drive future investigations on this topic

Educar para la sostenibilidad: el contexto de los problemas socio-científicos

Los avances científicos y tecnológicos de las últimas décadas nos han puesto en una nueva situación en la que la intervención humana en la naturaleza tiene la capacidad de producir riesgos que amenazan la supervivencia del planeta. Ante esta situación, se plantea la necesidad de incluir la educación para la sostenibilidad en la alfabetización científica de todos los ciudadanos. En concreto, se propone utilizar los problemas socio-científicos en el aula de ciencias como un contexto adecuado para contribuir a formar ciudadanos concientes de los riesgos globales y preparados para tomar decisiones responsables, a partir de determinados conocimientos científicos, junto a consideraciones éticas y morales. Diferentes estudios muestran una variedad de aspectos relacionados con las oportunidades que estos problemas pueden aportar al aula de ciencias, como: 1) la conceptualización de la naturaleza de la ciencia, el conocimiento científico y la toma de decisiones y 2) la capacidad de evaluar las pruebas y los aspectos morales y éticos implicados.Palabras clave: Problemas socio-científicos; sostenibilidad; alfabetización científica; toma de decisiones; responsabilidad social.Educating for sustainability: the context of socio-scientific issuesScientific and technological advances of recent decades have brought us a new situation in which human intervention in nature has the capacity to produce risks that threaten the survival of the planet. In this situation, inclusion of sustainability in scientific literacy of all citizens is needed. Socio-scientific issues represent a context for promoting scientific literacy and awareness of global risks to make responsible decisions on the basis of certain scientific knowledge with ethical and moral considerations. Different studies show a variety of aspects related to the opportunities that these problems bring to the science classroom, as the conceptualization of the nature of science, scientific knowledge and decision making, the ability to evaluate the evidence and issues moral and ethical concerns involved.Key Words: Socio-scientific issues; sustainability; scientific literacy; decision-making, social responsibility

sMILES SSPs: A Library of Semi-Empirical MILES Stellar Population Models with Variable [α\alpha/Fe] Abundances

We present a new library of semi-empirical stellar population models that are based on the empirical MILES and semi-empirical sMILES stellar libraries. The models span a large range of age and metallicity, in addition to an [$\alpha$/Fe] coverage from $-$0.2 to $+$0.6 dex, at MILES resolution (FWHM=2.5$\mathring {\mathrm A}$) and wavelength coverage (3540.5-7409.6$\mathring {\mathrm A}$). These models are aimed at exploring abundance ratios in the integrated light from stellar populations in star clusters and galaxies. Our approach is to build SSPs from semi-empirical stars at particular [$\alpha$/Fe] values, thus producing new SSPs at a range of [$\alpha$/Fe] values from sub-solar to super-solar. We compare these new SSPs with previously published and well-used models and find similar abundance pattern predictions, but with some differences in age indicators. We illustrate a potential application of our new SSPs, by fitting them to the high signal-to-noise data of stacked SDSS galaxy spectra. Age, metallicity and [$\alpha$/Fe] trends were measured for galaxy stacks with different stellar velocity dispersions and show systematic changes, in agreement with previous analyses of subsets of those data. These new SSPs are made publicly available.Comment: 21 pages, 18 figures plus Supplementary Material. Accepted for publication in MNRA

An equatorial ultra iron-poor star identified in BOSS

We report the discovery of SDSS J131326.89-001941.4, an ultra iron-poor red giant star ([Fe/H] ~ -4.3) with a very high carbon abundance ([C/Fe]~ +2.5). This object is the fifth star in this rare class, and the combination of a fairly low effective temperature (Teff ~ 5300 K), which enhances line absorption, with its brightness (g=16.9), makes it possible to measure the abundances of calcium, carbon and iron using a low-resolution spectrum from the Sloan Digital Sky Survey. We examine the carbon and iron abundance ratios in this star and other similar objects in the light of predicted yields from metal-free massive stars, and conclude that they are consistent. By way of comparison, stars with similarly low iron abundances but lower carbon-to-iron ratios deviate from the theoretical predictions.Comment: 6 pages, 4 figures, accepted for publication in A&

A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity

Malaria is a global health concern and research efforts are ongoing to develop a superior vaccine to RTS,S/AS01. To guide immunogen design, we seek a comprehensive understanding of the protective humoral response against Plasmodium falciparum circumsporozoite protein (PfCSP). In contrast to the well-studied responses to the repeat region and the C-terminus, the antibody response against the N-terminal domain of PfCSP (N-CSP) remains obscure. Here, we characterized the molecular recognition and functional efficacy of the N-CSP-specific monoclonal antibody 5D5. The crystal structure at 1.85 Åresolution revealed that 5D5 binds an α-helical epitope in N-CSP with high affinity through extensive shape and charge complementarity, and the unusual utilization of an N-linked glycan. Nevertheless, functional studies indicated low 5D5 binding to live Pf sporozoites, and lack of sporozoite inhibition in vitro and in mosquitoes. Overall, our data on low recognition and inhibition of sporozoites do not support the inclusion of the 5D5 epitope into the next generation of CSP-based vaccines.Summary Statement The Plasmodium falciparum sporozoite surface protein, PfCSP, is an attractive vaccine target, but the antibody response against the CSP N-terminal domain has remained understudied. Here, to guide immunogen design, Thai et al. provide insights into the binding motif and functional efficacy of the N-terminal domain-specific monoclonal antibody, 5D5