1,837 research outputs found
Criterion for purely elastic Taylor-Couette instability in the flows of shear-banding fluids
In the past twenty years, shear-banding flows have been probed by various
techniques, such as rheometry, velocimetry and flow birefringence. In micellar
solutions, many of the data collected exhibit unexplained spatio-temporal
fluctuations. Recently, it has been suggested that those fluctuations originate
from a purely elastic instability of the flow. In cylindrical Couette geometry,
the instability is reminiscent of the Taylor-like instability observed in
viscoelastic polymer solutions. In this letter, we describe how the criterion
for purely elastic Taylor-Couette instability should be adapted to
shear-banding flows. We derive three categories of shear-banding flows with
curved streamlines, depending on their stability.Comment: 6 pages, 3 figure
Potential "ways of thinking" about the shear-banding phenomenon
Shear-banding is a curious but ubiquitous phenomenon occurring in soft
matter. The phenomenological similarities between the shear-banding transition
and phase transitions has pushed some researchers to adopt a 'thermodynamical'
approach, in opposition to the more classical 'mechanical' approach to fluid
flows. In this heuristic review, we describe why the apparent dichotomy between
those approaches has slowly faded away over the years. To support our
discussion, we give an overview of different interpretations of a single
equation, the diffusive Johnson-Segalman (dJS) equation, in the context of
shear-banding. We restrict ourselves to dJS, but we show that the equation can
be written in various equivalent forms usually associated with opposite
approaches. We first review briefly the origin of the dJS model and its initial
rheological interpretation in the context of shear-banding. Then we describe
the analogy between dJS and reaction-diffusion equations. In the case of
anisotropic diffusion, we show how the dJS governing equations for steady shear
flow are analogous to the equations of the dynamics of a particle in a quartic
potential. Going beyond the existing literature, we then draw on the Lagrangian
formalism to describe how the boundary conditions can have a key impact on the
banding state. Finally, we reinterpret the dJS equation again and we show that
a rigorous effective free energy can be constructed, in the spirit of early
thermodynamic interpretations or in terms of more recent approaches exploiting
the language of irreversible thermodynamics.Comment: 14 pages, 6 figures, tutorial revie
Patient-Specific Injury Metrics Predict Early Biomarker Response in Multiply Injured Patients
poster abstractIntroduction: It is important to identify multiply injured patients (MIPs) that can tolerate
high-magnitude procedures and those at risk for complications. Determining how injury
leads to immunologic dysfunction could identify MIPs at risk for complications. We
explored a new precision medicine approach in which we determined how patientspecific
injury metrics corresponded to changes in cytokines in a prospective cohort of
MIPs.
Methods: This was a prospective observational cohort of 40 MIPs, 18-55 yo, admitted
to surgical ICU having had full axial CTs done at admission. Mechanical tissue damage
was quantified by calculating volumetric measures of injuries from CT scans into the
Tissue Damage Volume score (TDV). Ischemic tissue damage was calculated by
calculation of all abnormal Shock Volumes (SV) (heart rate/systolic blood pressure >
0.9) in the first 24hr after injury. TIMS was calculated by combining mechanical and
ischemic tissue damage: TIMS = TDV+5*SV. Linear regression was performed between
TIMS and 21 cytokines including interleukin (IL)-6; IL-8; IL-10; IL-1RA; IL-2RA; MCP-1
drawn at 0hr, 8hr, and 24hr after injury. Linear regression was also performed between
the cytokines, Injury Severity Score (ISS) and minimum pH (day 1).
Results: Mean and median ISS was 29 (range 9 – 66). Minimum pH demonstrated best
correspondence to cytokine levels measured 0hr and 8hr after injury. TIMS
demonstrated the best correspondence to cytokine levels 24hr after injury. ISS
demonstrated minimal predictive value of cytokines at any timepoint.
Discussion: A precision medicine approach using a patient-specific quantity of injury
predicted trauma-associated changes in circulating cytokines at 0hr, 8 hr, and 24 hr
after surgery. This corresponds favorably with timing of orthopaedic surgical decisions
regarding staged fracture interventions. While clinical significance of these findings is
unknown, computational data analyses of temporal cytokine changes have been shown
to be predictive of adverse outcomes after injury
On the Emergence of Tremor in Prodromal Parkinson's Disease
Clinical, neuropathological and neuroimaging research suggests that pathological changes in Parkinson’s disease (PD) start many years before the emergence of motor signs. Since disease-modifying treatments are likely to be most effective when initiated early in the disease process, there has been significant interest in characterizing prodromal PD. Some people with PD describe autonomic symptoms at the time of diagnosis suggesting that autonomic dysfunction is a common feature of prodromal PD. Furthermore, subtle motor signs may be present and emerge prior to the time of diagnosis. We present a series of patients who, in the prodromal phase of PD, experienced the emergence of tremor initially only while yawning or straining at stool and discuss how early involvement of autonomic brainstem nuclei could lead to these previously unreported phenomena. The hypothalamic paraventricular nucleus (PVN) plays a central role in autonomic control including bowel/bladder function, cardiovascular homeostasis and yawning and innervates multiple brainstem nuclei involved in autonomic functions (including brainstem reticular formation, locus ceruleus, dorsal raphe nucleus and motor nucleus of the vagus). The PVN is affected in PD and evidence from related phenomena suggest that the PVN could increase tremor either by increasing downstream cholinergic activity on brainstem nuclei such as the reticular formation or by stimulating the locus ceruleus to activate the cerebellothalamocortical network via the ventrolateral nucleus of the thalamus. Aberrant cholinergic/noradrenergic transmission between these brainstem nuclei early in PD couldlead to tremor before the emergence of other parkinsonian signs, representing an early clinical clue to prodromal PD
Drop Formation and Breakup of Low Viscosity Elastic Fluids: Effects of Molecular Weight and Concentration
Submitted to Phys. FluidsThe dynamics of drop formation and pinch-off have been investigated for a series of low viscosity elastic fluids possessing similar shear viscosities, but differing substantially in elastic properties. On initial approach to the pinch region, the viscoelastic fluids all exhibit the same global necking behaviour that is observed for a Newtonian fluid of equivalent shear viscosity. For these low viscosity dilute polymer solutions, inertial and capillary forces form the dominant balance in this potential flow regime, with the viscous force being negligible. The approach to the pinch point, which corresponds to the point of rupture for a Newtonian fluid, is extremely rapid in such solutions, with the sudden increase in curvature producing very large extension rates at this location. In this region the polymer molecules are significantly extended, causing a localised increase in the elastic stresses, which grow to balance the capillary pressure. This prevents the necked fluid from breaking off, as would occur in the equivalent Newtonian fluid. Alternatively, a cylindrical filament forms in which elastic stresses and capillary pressure balance, and the radius decreases exponentially with time. A (0+1)-dimensional FENE dumbbell theory incorporating inertial, capillary and elastic stresses is able to capture the basic features of the experimental observations. Before the critical ‘pinch time’ tp , an inertial-capillary balance leads to the expected 2/3-power scaling of the minimum radius with time, Rmin ∼ (tp − t)^2/3. However, the diverging deformation rate results in large molecular deformations and rapid crossover to an elasto-capillary balance for times t > tp. In this region the filament radius decreases exponentially with time Rmin ~exp[(tp - t) / λ1], where λ1 is the characteristic time constant of the polymer
molecules. Measurements of the relaxation times of PEO solutions of varying concentrations and molecular weights obtained from high speed imaging of the rate of change of filament radius are significantly higher than the relaxation times estimated from Rouse-Zimm theory, even though the solutions are within the dilute concentration region as determined using intrinsic viscosity measurements. The effective relaxation times exhibit the expected scaling with molecular weight but with an additional dependence on the concentration of the polymer in solution. This is consistent with the expectation that the polymer molecules are in fact highly extended during the approach to the pinch region (i.e. prior to the elasto-capillary filament thinning regime) and subsequently as the filament is formed they are further
extended by filament stretching at a constant rate until full extension of the polymer coil is achieved. In this highly-extended state, inter-molecular interactions become significant producing relaxation times far above theoretical predictions for dilute polymer solutions under equilibrium conditions.Australian Research Counci
Severe muscle trauma triggers heightened and prolonged local musculoskeletal inflammation and impairs adjacent tibia fracture healing
Objectives:
Complicated fracture healing is often associated with the severity of surrounding muscle tissue trauma. Since inflammation is a primary determinant of musculoskeletal health and regeneration, it is plausible that delayed healing and non-unions are partly caused by compounding local inflammation in response to concomitant muscle trauma.
Methods and results:
To investigate this possibility, a Lewis rat open fracture model [tibia osteotomy with adjacent tibialis anterior (TA) muscle volumetric muscle loss (VML) injury] was interrogated. We observed that VML injury impaired tibia healing, as indicated by diminished mechanical strength and decreased mineralized bone within the fracture callus, as well as continued presence of cartilage instead of woven bone 28 days post-injury. The VML injured muscle presented innate and adaptive immune responses that were atypical of canonical muscle injury healing. Additionally, the VML injury resulted in a perturbation of the inflammatory phase of fracture healing, as indicated by elevations of CD3+ lymphocytes and CD68+ macrophages in the fracture callus at 3 and 14d post-injury, respectively.
Conclusions:
These data indicate that heightened and sustained innate and adaptive immune responses to traumatized muscle are associated with impaired fracture healing and may be targeted for the prevention of delayed and non-union following musculoskeletal trauma
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