Convergence of institutes of functional representation of group interests under transformation of social processes, quality of life, and human capital

This article substantiates the influence of mechanisms, methods, and technologies of a functional representation of group interests on the strategic management of socio-economic processes in the context of geopolitical turbulenc

Differentiation of the regions of the central federal district of the Russian Federation according to the level of competitive advantages

The article reveals the methodology of competitive positioning of the regions, based on the clustering of the initial key competitive indicators, including those reflecting the regional resource potentia

Development of the Russian economy in a trend of current trends of technological effectiveness and knowledge intensity

A research objective is the analysis of the development of the Russian economy in a trend of current trends of technological effectiveness and knowledge intensity and establishment of a problem of the use of the human capital in the hi-tech enterprises of the industry of Russi

Beta-cell autophagy under the scope of hypoglycemic drugs; possible mechanism as a novel therapeutic target

Physiologically, autophagy is a major protective mechanism of β-cells from apoptosis, through can reserve normal β- cell mass and inhibit the progression of β-cells destruction. Beta-cell mass can be affected by differentiation from progenitors and de-differentiation as well as self-renewal and apoptosis. Shred evidence indicated that hypoglycemic drugs can induce β-cell proliferation capacity and neogenesis via autophagy stimulation. However, prolonged use of selective hypoglycemic drugs has induced pancreatitis besides several other factors that contribute to β-cell destruction and apoptosis initiation. Interestingly, some nonhypoglycemic medications possess the same effects on β-cells but depending on the combination of these drugs and the duration of exposure to β-cells. The paper comprehensively illustrates the role of the hypoglycemic drugs on the insulin-producing cells and the pathogeneses of β-cell destruction in type 2 diabetes mellitus, in addition to the regulation mechanisms of β-cells division in norm and pathology. The grasping of the hypoglycemic drug’s role in beta-cell is clinically crucial to evaluate novel therapeutic targets such as new signaling pathways. The present paper addresses a new strategy for diabetes mellitus management via targeting specific autophagy inducer factors (transcription factors, genes, lipid molecules, etc.)

Peculiarities of the University’s Educational Environment Implementation in the Organization of Future Teachers’ Pedagogical Practice

The article addresses contradictions between the existing and predicted tendencies in the organization and content of pedagogical practices. Through the analysis of teacher training programs, the need for student educational practice has also been established, which provides a solution to a wider range of professional tasks. The revealed contradictory nature made it possible to formulate the problem: what can be a trigger for the initiative acquisition by a future teacher of the experience in solving professional problems? Primary attention in solving this problem is paid to the conditions for the manifestation of personal student initiatives: the creation of platforms for dialogue, the provision of a periodic process of transition from practice to theory and vice versa, the use of operators of semiotic diagnostics of changes in students’ personal interests. The article presents the experience of organizing the educational environment, which provides future teachers with a modern range of professional probation. The options for the organization of official student practice are presented, including the development of online classes of educational and leisure activities of schoolchildren. This model contributes to the manifestation of students’ personal initiatives, both within the training profile and in the sphere of interdisciplinary intersections. The authors adduce the results of the questionnaire survey of students after the practice, showing their satisfaction with the chosen profession, a high level of motivation for mastering professional actions. The main methods and directions of organizing practices have been determined. They make it possible to ensure the predicted level of solving professional tasks by graduates