Inhomogeneous Coupling in Two-Channel Asymmetric Simple Exclusion Processes

Asymmetric exclusion processes for particles moving on parallel channels with inhomogeneous coupling are investigated theoretically. Particles interact with hard-core exclusion and move in the same direction on both lattices, while transitions between the channels is allowed at one specific location in the bulk of the system. An approximate theoretical approach that describes the dynamics in the vertical link and horizontal lattice segments exactly but neglects the correlation between the horizontal and vertical transport is developed. It allows us to calculate stationary phase diagrams, particle currents and densities for symmetric and asymmetric transitions between the channels. It is shown that in the case of the symmetric coupling there are three stationary phases, similarly to the case of single-channel totally asymmetric exclusion processes with local inhomogeneity. However, the asymmetric coupling between the lattices lead to a very complex phase diagram with ten stationary-state regimes. Extensive Monte Carlo computer simulations generally support theoretical predictions, although simulated stationary-state properties slightly deviate from calculated in the mean-field approximation, suggesting the importance of correlations in the system. Dynamic properties and phase diagrams are discussed by analyzing constraints on the particle currents across the channels

Parallel Coupling of Symmetric and Asymmetric Exclusion Processes

A system consisting of two parallel coupled channels where particles in one of them follow the rules of totally asymmetric exclusion processes (TASEP) and in another one move as in symmetric simple exclusion processes (SSEP) is investigated theoretically. Particles interact with each other via hard-core exclusion potential, and in the asymmetric channel they can only hop in one direction, while on the symmetric lattice particles jump in both directions with equal probabilities. Inter-channel transitions are also allowed at every site of both lattices. Stationary state properties of the system are solved exactly in the limit of strong couplings between the channels. It is shown that strong symmetric couplings between totally asymmetric and symmetric channels lead to an effective partially asymmetric simple exclusion process (PASEP) and properties of both channels become almost identical. However, strong asymmetric couplings between symmetric and asymmetric channels yield an effective TASEP with nonzero particle flux in the asymmetric channel and zero flux on the symmetric lattice. For intermediate strength of couplings between the lattices a vertical cluster mean-field method is developed. This approximate approach treats exactly particle dynamics during the vertical transitions between the channels and it neglects the correlations along the channels. Our calculations show that in all cases there are three stationary phases defined by particle dynamics at entrances, at exits or in the bulk of the system, while phase boundaries depend on the strength and symmetry of couplings between the channels. Extensive Monte Carlo computer simulations strongly support our theoretical predictions.Comment: 16 page

Theoretical Investigation of Totally Asymmetric Exclusion Processes on Lattices with Junctions

Totally asymmetric simple exclusion processes on lattices with junctions, where particles interact with hard-core exclusion and move on parallel lattice branches that at the junction combine into a single lattice segment, are investigated. A simple approximate theory, that treats the correlations around the junction position in a mean-field fashion, is developed in order to calculate stationary particle currents, density profiles and a phase diagram. It is shown that there are three possible stationary phases depending on the state of each of the lattice branch. At first-order phase boundaries, where the density correlations are important, a modified phenomenological domain-wall theory, that accounts for correlations, is introduced. Extensive Monte Carlo computer simulations are performed to investigate the system, and it is found that they are in excellent agreement with theoretical predictions.Comment: 16 pages, 7 figure

Spontaneous Symmetry Breaking in Two-Channel Asymmetric Exclusion Processes with Narrow Entrances

Multi-particle non-equilibrium dynamics in two-channel asymmetric exclusion processes with narrow entrances is investigated theoretically. Particles move on two parallel lattices in opposite directions without changing them, while the channels are coupled only at the boundaries. A particle cannot enter the corresponding lane if the exit site of the other lane is occupied. Stationary phase diagrams, particle currents and densities are calculated in a mean-field approximation. It is shown that there are four stationary phases in the system, with two of them exhibiting spontaneous symmetry breaking phenomena. Extensive Monte Carlo computer simulations confirm qualitatively our predictions, although the phase boundaries and stationary properties deviate from the mean-field results. Computer simulations indicate that several dynamic and phase properties of the system have a strong size dependency, and one of the stationary phases predicted by the mean-field theory disappears in the thermodynamic limit.Comment: 13 page

Dynamic Boundaries in Asymmetric Exclusion Processes

We investigate the dynamics of a one-dimensional asymmetric exclusion process with Langmuir kinetics and a fluctuating wall. At the left boundary, particles are injected onto the lattice; from there, the particles hop to the right. Along the lattice, particles can adsorb or desorb, and the right boundary is defined by a wall particle. The confining wall particle has intrinsic forward and backward hopping, a net leftward drift, and cannot desorb. Performing Monte Carlo simulations and using a moving-frame finite segment approach coupled to mean field theory, we find the parameter regimes in which the wall acquires a steady state position. In other regimes, the wall will either drift to the left and fall off the lattice at the injection site, or drift indefinitely to the right. Our results are discussed in the context of non-equilibrium phases of the system, fluctuating boundary layers, and particle densities in the lab frame versus the frame of the fluctuating wall.Comment: 13 page

Traffic jams induced by rare switching events in two-lane transport

We investigate a model for driven exclusion processes where internal states are assigned to the particles. The latter account for diverse situations, ranging from spin states in spintronics to parallel lanes in intracellular or vehicular traffic. Introducing a coupling between the internal states by allowing particles to switch from one to another induces an intriguing polarization phenomenon. In a mesoscopic scaling, a rich stationary regime for the density profiles is discovered, with localized domain walls in the density profile of one of the internal states being feasible. We derive the shape of the density profiles as well as resulting phase diagrams analytically by a mean-field approximation and a continuum limit. Continuous as well as discontinuous lines of phase transition emerge, their intersections induce multi-critical behaviour

Distance learning on epidemic and pandemic outbreaks in Belarus as a result of cooperation with СEI

Summary Several scientific institutions have performed CEI project in Belarus: Republican Scientific and Practical Centre of Hygiene, which is an advanced scientific and testing institution in the field of hygiene, toxicology, health protection and preventive medicine and Republican Research and Practical Center for Epidemiology and Microbiology, with a wide range of fundamental studies in the area of epidemiology, medical virology, microbiology, immunology and parasitology. The situational analysis showed that existing structure of sanitary epidemiological system in Belarus let to enhance and strengthen the national surveillance system and public health safety. The e-learning course have been developed within the project framework consists of two training modules. The epidemiological e-learning course “Laboratory diagnosis of a new COVID-19 infection COVID-19” addressed to the health care workers, state sanitary inspections specialists and other medical specialists. The public health e-learning course “Occupational risk management of medical workers in context of Covid-19” addressed to the occupational health services specialists, clinical epidemiologists, hospital managers and administrators, representatives of the health workers' union. These topics were based on the training need analysis conducted by Istituto Superiore di Sanità. Using the educational platform let the participated institutions to efficiently disseminate the project results on ongoing basis

Population Size, Sex and Purifying Selection: Comparative Genomics of Two Sister Taxa of the Wild Yeast Saccharomyces paradoxus

This study uses population genomic data to estimate demographic and selection parameters in two sister lineages of the wild yeast Saccharomyces paradoxus and compare their evolution. We first estimate nucleotide and recombinational diversities in each of the two lineages to infer their population size and frequency of sex and then analyze the rate of mutation accumulation since divergence from their inferred common ancestor to estimate the generation time and efficacy of selection. We find that one of the lineages has significantly higher silent nucleotide diversity and lower linkage disequilibrium, indicating a larger population with more frequent sexual generations. The same lineage also shows shorter generation time and higher efficacy of purifying selection, the latter consistent with the finding of larger population size and more frequent sex. Similar analyses are also performed on the ancestries of individual strains within lineages and we find significant differences between strains implying variation in rates of mitotic cell divisions. Our sample includes some strains originating in the Chernobyl nuclear-accident exclusion zone, which has been subjected to high levels of radiation for nearly 30 years now. We find no evidence, however, for increased rates of mutation. Finally, there is a positive correlation between rates of mutation accumulation and length of growing period, as measured by latitude of the place of origin of strains. Our study illustrates the power of genomic analyses in estimating population and life history parameters and testing predictions based on population genetic theory

Spontaneous symmetry breaking in a two-lane model for bidirectional overtaking traffic

First we consider a unidirectional flux \omega_bar of vehicles each of which is characterized by its `natural' velocity v drawn from a distribution P(v). The traffic flow is modeled as a collection of straight `world lines' in the time-space plane, with overtaking events represented by a fixed queuing time tau imposed on the overtaking vehicle. This geometrical model exhibits platoon formation and allows, among many other things, for the calculation of the effective average velocity w=\phi(v) of a vehicle of natural velocity v. Secondly, we extend the model to two opposite lanes, A and B. We argue that the queuing time \tau in one lane is determined by the traffic density in the opposite lane. On the basis of reasonable additional assumptions we establish a set of equations that couple the two lanes and can be solved numerically. It appears that above a critical value \omega_bar_c of the control parameter \omega_bar the symmetry between the lanes is spontaneously broken: there is a slow lane where long platoons form behind the slowest vehicles, and a fast lane where overtaking is easy due to the wide spacing between the platoons in the opposite direction. A variant of the model is studied in which the spatial vehicle density \rho_bar rather than the flux \omega_bar is the control parameter. Unequal fluxes \omega_bar_A and \omega_bar_B in the two lanes are also considered. The symmetry breaking phenomenon exhibited by this model, even though no doubt hard to observe in pure form in real-life traffic, nevertheless indicates a tendency of such traffic.Comment: 50 pages, 16 figures; extra references adde

A model for bidirectional traffic of cytoskeletal motors

We introduce a stochastic lattice gas model including two particle species and two parallel lanes. One lane with exclusion interaction and directed motion and the other lane without exclusion and unbiased diffusion, mimicking a micotubule filament and the surrounding solution. For a high binding affinity to the filament, jam-like situations dominate the system's behaviour. The fundamental process of position exchange of two particles is approximated. In the case of a many-particle system, we were able to identify a regime in which the system is rather homogenous presenting only small accumulations of particles and a regime in which an important fraction of all particles accumulates in the same cluster. Numerical data proposes that this cluster formation will occur at all densities for large system sizes. Coupling of several filaments leads to an enhanced cluster formation compared to the uncoupled system, suggesting that efficient bidirectional transport on one-dimensional filaments relies on long-ranged interactions and track formation.Comment: 20 pages, 9 figure