25,667 research outputs found

    Genetic and environmental risk factors for sexual distress and its association with female sexual dysfunction

    Get PDF
    A. Burri, Q. Rahman and T. Spector (2011). Genetic and environmental risk factors for sexual distress and its association with female sexual dysfunction. Psychological Medicine, 41, pp 2435-2445. Copyright © Cambridge University Press 2011. http://dx.doi.org/10.1017/S003329171100049

    Simulated rotor test apparatus dynamic characteristics in the 80- by 120-foot wind tunnel

    Get PDF
    A shake test was conducted in the 80 by 120 foot Wind Tunnel at NASA Ames Research Center, using a load frame and dummy weights to simulate the weight of the NASA Rotor Test Apparatus. The simulated hub was excited with broadband random excitation, and accelerometer responses were measured at various locations. The transfer functions (acceleration per unit excitation force as a function of frequency) for each of the accelerometer responses were computed, and the data were analyzed using modal analysis to estimate the model parameters

    Zebrafish-Based Small Molecule Discovery

    Get PDF
    AbstractThe earliest examples of small molecule discovery involved serendipitous phenotypic observations in whole organisms, but this organism-based process has given way in recent decades to systematic, high-throughput assays using purified proteins, cells, or cell extracts. In vitro screens have been successful at identifying modifiers of well-understood biological processes, but they are limited in their ability to discover modifiers of processes that are poorly understood or occur only in an integrated physiological context. Small model organisms, especially the zebrafish, make it possible to combine the advantages of organism-based small molecule discovery with the technologies and throughput of modern screening. The combination of model organisms with high-throughput screening is likely to extend small molecule discovery efforts to fields of study such as developmental biology and to broaden the range of diseases for which drug screening can be performed
    • …
    corecore