Infrastructure coverage of the ural federal district regions: assessment metodology and diagnostic results

The article examines the infrastructure as one of the essential elements in the economic system. The authors consider the development stages of this concept in the scientific community and provide the opinions of a number of researchers as to the role and place of the infrastructure in the economic system. The article provides a brief genesis of approaches to describing the infrastructure and conferring its functions on individual branches. The authors emphasize the higher importance of infrastructure coverage with the economy transition to machine production. Two key methodological approaches are identified to describe the substance and content of the infrastructure: industrial and functional. The authors offer their methodology of assessing the infrastructure coverage of regional-level territories. The methodology is based on identifying a combination of specific indicators the values of which can be used to evaluate the development level of individual infrastructure elements. The indicative analysis being the basis of the methodological apparatus helps make a judgment of any phenomenon by comparing the current observed values with the previously adopted threshold levels. Such comparison makes it possible to classify the observations by the «norm—pre-crisis—crisis» scale. An essential advantage of this method is the possibility of standardizing the indicators, or, in other words, bringing them to one comparable conditional value. Thus, you can get estimates for individual blocks of indicators and a complex assessment for the whole set in general. The authors have identified four main infrastructure elements: transport, communications, public utility services and healthcare. The methodology includes 21 indicators all together. The test estimates based on the authors’ methodology revealed the defects in the development of the Ural regions` infrastructure. The article provides a brief analysis of the obtained data with identifying individual indicators and areas.The research has been supported by the Russian Science Foundation (Project № 14-18-00574)

Psychological features of personal development of younger adolescents in the process of leisure activities

The article presents the results of analysis of younger adolescents’ psychological characteristics and provides a description of a comprehensive program created in order to ensure effective personal development of children in this age group in the process of carrying out leisure activities. To test the program, a sample was formed consisting of 60 adolescents studying at Municipal Budgetary General Education Institution “School No. 134” in Nizhny Novgorod. The results of the study indicate significant changes among all criteria analyzed for the experimental and the control groups. The scientific significance of the data obtained lies in the expansion of the idea of younger adolescents’ personal qualities’ multidimensionality and the opportunity provided to study the phenomenon in more detail. Indicators obtained during the course of the study can be used to organise extracurricular activities for adolescents, hold seminars and personal development trainings as well as develop methodological manuals on personality psychology

The mechanism of state-public management of vocational education in the region

© 2016, Econjournals. All rights reserved.The relevance of the article is reasoned by the development of civil society and the positioning of vocational education as an open, state-public system. The purpose of the article is to develop a mechanism of state-public management of vocational education in the region. The leading method is the method of action research, allowing obtain new knowledge about state-public management of vocational education in the region and to organize the systematic monitoring of the changes in state-society relations in the management of vocational education. The article reveals the essence and defines the principles of state-public management of vocational education in the region; presents a mechanism of state-public management of vocational education in the region, providing a constructive dialogue between the entities of management process and the formation of a unified regional educational environment. Article submissions may be useful for research and teaching staff of the system of vocational education, specialists of education management bodies and regional authorities

Study of acute and chronic toxicity of feed additive based on vermiculture

The paper presents the results of study of the toxicity of a feed additive, which includes Leuzea safflower (Rhaponticum carthamoides) and protein obtained from vermiculture. The acute toxicity of the feed additive was studied in 31 SD white rats. It has been established that the acute oral toxicity of the feed additive is above 2500 mg/kg, which makes it possible to classify the feed additive as hazard class 3 and classify it as “moderately hazardous” according to GOST 12.1.007-76. The chronic toxicity of the feed additive was studied in 22 SD white rats. The feed additive was administered orally at a dose of 120 and 1200 mg/kg for 30 days. Long-term effects were assessed 14 days after the last introduction of the feed additive. To assess the toxic effects, the effect of the additive on the general condition of the animals, food and water intake was evaluated, blood and urine were analyzed. Complete blood count was carried out by standard methods with the determination of the following parameters: hematocrit, hemoglobin level, the number of erythrocytes, platelets, leukocytes, eosinophils, segmented neutrophils, lymphocytes and monocytes. The study of biochemical parameters of blood was carried out using standard kits for biochemical analysis. The following indicators were determined: ALT, total bilirubin, glucose, creatinine and urea. The urinalysis included the determination of the following indicators: density, leukocytes, nitrites, pH, erythrocytes, protein,  glucose, ascorbic acid, ketones, urobilinogen, bilirubin. There was no statistically significant difference in blood and urine parameters between the animals of the control and experimental groups. A pathohistological examination of the stomach, liver, kidneys and heart was carried out, which showed the absence of a toxic effect of the feed additive. Local irritant action was studied in pathomorphological studies. It has been established that the feed additive does not have an irritating effect at the injection site. Thus, the feed additive can be used in feeding farm animals and birds at the recommended dose

The managerial mechanism of future competitive technical specialists vocational training: The Russian experience

© 2016, Econjournals. All rights reserved.The relevance of the paper is reasoned by the search for adequate mechanisms to manage vocational training of future competitive technical specialists. Modern economies demand the training of technical specialists’ new generation ready to project and engineering, production and technological, organizational and management, science and research, service and operational professional activities, as well as the fulfillment of skilled work using modern equipment for the developed technological process. One of the variants of the organization of vocational training of future competitive technical specialists is based on the integration of educational curricula of different levels (primary, secondary and high). The purpose of the paper is to develop a managerial mechanism for future competitive technical specialists’ training based on the integration of educational curricula at different levels (primary, secondary and high). The leading method is the method of action research, allowing obtain new knowledge on the managerial mechanism for vocational training of specialists, capable of a certain type of practical activities, self-organization and competitiveness on the labor market through the integration of primary, secondary and high levels of educational curricula. The article defines the essence of integrated educational curricula of primary, secondary and high levels of vocational training; it justifies the organization of control and assessment procedures of students’ vocational training through the integration of educational curricula at different levels; proposes an algorithm of students’ selection to study on integrated educational curricula. Paper Submissions can be useful for research and teaching staff of technical specialists’ vocational training system, experts of training and retraining centers in the training content’s selection and structuring of research universities’ scientific and pedagogical staff development

The use of controlled balloon tamponade in an obstetric hospital

Obstetric haemorrhage is an important problem worldwide and is a frequent cause of maternal mortality. One of the conservative methods of treatment is a controlled balloon tamponade, which has shown its effectiveness when used. This work is to study the effectiveness of the use of UBT on the example of treatment of hypotonic bleeding in the Tyumen regional Perinatal center. The obtained results have allowed to draw a conclusion about high efficiency of use of this method.Акушерские кровотечения являются важной проблемой во всем мире, являясь частой причиной материнской смертности. Одним из консервативных способов лечения является управляемая баллонная тампонада, показавшая свою эффективность при использовании. Данная работа заключается в изучении эффективности использования УБТ на примере лечения гипотонических кровотечений в Тюменском областном Перинатальном центре. Полученнные результаты позволили сделать вывод о высокой эффективности использования данного метода

CHANGE OF NON-SPECIFIC FACTORS OF IMMUNITY UNDER INFLUENCE OF INTERFERON INDUCTOR (CYCLOFERON) IN BRONCHIAL ASTHMA IN CHILDREN

The aim of the work was to evaluate the effect of immunomodulation therapy on factors of nonspecific immunity in children with bronchial asthma (BA) by including interferon (cycloferon) in a standard therapy. 120 children with BA aged from 5 to 14 were examined. The main group (n = 60) included children who, in addition to basic therapy, received an interferon inducer (cycloferon) according to the generally accepted scheme. In comparison group were children who received only basic therapy (n = 60), depending on the severity of the disease. In control group were 25 healthy children. The level of serum interferon, virus-induced interferon production (VII), mitogen-stimulated production of interferon (MSI), phagocytic activity of neutrophils, as well as spontaneous and induced activity were determined. The arithmetic mean (M) and the absolute value error (m) were statistically calculated. The reliability of the differences was determined by the t-test of the Student (p < 0,05). The analysis of the indices of interferon status and phagocytic activity, depending on the type of therapeutic tactics, showed that as a result of the inclusion of cycloferon in the baseline, there was a significant increase in the levels of VII (p < 0,05) and MSI (p < 0,05 ), spontaneous and induced neutrophil activity. It was noted that this positive effect was more noticeable in moderate and severe BA (p < 0,05). Activation of factors of nonspecific protection contributed to a decrease in the frequency of exacerbations of BA in children, as well as a longer-term clinical remission in this contingent of children

The morphofunctional and biochemical characteristics of opisthorchiasis-associated cholangiocarcinoma in a Syrian hamster model

The validity of experimental models of pathologies is one of the key challenges in translational medicine. Cholangiocarcinoma, or bile duct cancer, ranks second among oncological diseases of the liver. There is a strong association between bile duct cancer and parasitic infestation of the liver caused by trematodes in the family Opisthorchiidae. We have recently demonstrated that cholangiocarcinoma can develop in Syrian hamsters (Mesocricetus auratus) infected by Opisthorchis felineus and administered with dimethylnitrosamine. However, there is still no description of how this experimental model can possibly be used in translational research. The aim of this work was to study the morphological, functional and biochemical characteristics during cholangiocarcinoma development in Syrian hamsters infected by O. felineus and administered with dimethylnitrosamine. The experi­ment lasted 30 weeks with combined exposure to dimethylnitrosamine in drinking water at a dose of 12.5 ppm and a single injection of 50 metacercariae O. felineus. It was shown that the development of cholangiocarcinoma (18 weeks) increased the total number of basophils, eosinophils and monocytes, the relative number of granulocytes, the amount of total and direct bilirubin, and cholesterol and ALT levels, but reduced the relative number of lymphocytes. Based on pathological, morphometric and biochemical analyses, our model has characteristics similar to those in patients with opisthorchiasisassociated cholangiocarcinoma. Thus, this model can be used to test anticancer drugs, to study the mechanisms of cholangiocarcinogenesis and to search for molecular markers for early diagnosis of bile duct cancer

Prime movers : mechanochemistry of mitotic kinesins

Mitotic spindles are self-organizing protein machines that harness teams of multiple force generators to drive chromosome segregation. Kinesins are key members of these force-generating teams. Different kinesins walk directionally along dynamic microtubules, anchor, crosslink, align and sort microtubules into polarized bundles, and influence microtubule dynamics by interacting with microtubule tips. The mechanochemical mechanisms of these kinesins are specialized to enable each type to make a specific contribution to spindle self-organization and chromosome segregation

Phosphorylation controls autoinhibition of cytoplasmic linker protein-170

Author Posting. © American Society for Cell Biology, 2010. This article is posted here by permission of American Society for Cell Biology for personal use, not for redistribution. The definitive version was published in Molecular Biology of the Cell 21 (2010): 2661-2673, doi:10.1091/mbc.E09-12-1036.Cytoplasmic linker protein (CLIP)-170 is a microtubule (MT) plus-end-tracking protein that regulates MT dynamics and links MT plus ends to different intracellular structures. We have shown previously that intramolecular association between the N and C termini results in autoinhibition of CLIP-170, thus altering its binding to MTs and the dynactin subunit p150Glued (J. Cell Biol. 2004: 166, 1003–1014). In this study, we demonstrate that conformational changes in CLIP-170 are regulated by phosphorylation that enhances the affinity between the N- and C-terminal domains. By using site-directed mutagenesis and phosphoproteomic analysis, we mapped the phosphorylation sites in the third serine-rich region of CLIP-170. A phosphorylation-deficient mutant of CLIP-170 displays an "open" conformation and a higher binding affinity for growing MT ends and p150Glued as compared with nonmutated protein, whereas a phosphomimetic mutant confined to the "folded back" conformation shows decreased MT association and does not interact with p150Glued. We conclude that phosphorylation regulates CLIP-170 conformational changes resulting in its autoinhibition.This work was supported by National Institutes of Health grant GM-25062 (to G.G.B.); Netherlands Organization for Scientific Research grants (to A. A. and N. G.); a Cancer Genomics Centre grant (to J.v.H.); and Presidential Program of Russian Academy of Sciences and RFBP grant 05-04-4915 (to E.S.N.)