Correction of morphofunctional disorders of the cardiovascular system with asialized erythropoietin and arginase II selective inhibitors KUD 974 and KUD 259 in experimental preeclampsia

The aim of the present study was to study the effectiveness of asialized erythropoietin and arginase II selective inhibitors: KUD-259 and KUD-974 in the correction of morphofunctional disorders of the cardiovascular system in experimental preeclampsi

Роль протеолитических систем стромы в опухолевой прогрессии (обзор)

Oncological diseases belong to life-threatening pathologies being the second most frequent cause of morbidity and mortality after cardiovascular diseases. Clarification of carcinogenesis mechanisms makes it possible to expand the stock of tools available for prevention of critical illness accompanying this pathological condition.Nowadays, proteolytic systems of tumor microenvironment (ТМЕ) are regarded as key regulators of a tumor progression including tumor growth, invasion and metastazing. The review discusses ТМЕ structure and role in cancer progression.Recent data decipher the role of proteolytic systems in the interaction stromal cells with tumor cells in different types of cancer in humans. The most known proteolytic systems contributed to cancer progression are matrix metalloproteinase system (MMP), urokinase-type plasminogen activator system (uPA-system), various cathepsins, granzymes, and elastase. Inhibition of extracellular proteolysis in the course of an oncological process is considered an effective approach to cancer therapy.Онкологические заболевания являются жизнеугрожающей патологией, занимающей второе место среди причин заболеваемости и смертности после сердечно-сосудистых заболеваний. Выяснение механизмов процесса канцерогенеза позволяет расширить арсенал средств для предупреждения развития критических состояний при этой патологии.В настоящее время протеолитические системы опухолевого микроокружения (ОМ) рассматриваются в качестве ключевых регуляторов процессов опухолевой прогрессии, обеспечивающих опухолевый рост, инвазию и метастазирование.В обзоре рассмотрены структура и роль ОМ в прогрессии опухоли. Приводятся современные данные о роли протеолитических систем во взаимодействии клеток стромы с клетками опухоли при различных типах рака человека.Наиболее изученными протеолитическими системами, вовлеченными в опухолевую прогрессию, являются система матриксных металлопротеиназ (ММП), системы активатора плазминогена урокиназного типа (uPA-система), а также различные катепсины, гранзимы и эластаза. Ингибирование внеклеточного протеолиза при развитии онкологического процесса рассматривается в качестве действенного подхода в терапии рака

Megasports events as an instrument for development adaptive (in focus of the XVIII Deaflympic winter games - 2015)

Nowadays the problems of disabled people and disability are one of the most important government problems, because this problem concerns a large number of people with disability. Disability is a social phenomenon that no country can avoid. One of the most essential directions of disabled people integration in our society and their successful physical recovery are physical culture and sport. It is just as important as rehabilitation with the help of education and work. Physical culture and sport for disabled are generally considered to be not only a method of physical rehabilitation, but also a method of social rehabilitation (social activity and personal achievements) - a permanentform of vital energy. The basic instruments ofdevelopment ofadaptive sports are examined in this article. Special attention is paid to sport events, particularly to the XVIII Deaflympic Winter Games, which were held in Hanty-Mansiysk, Russia in 2015

The Role of Stromal Proteolytic Systems in Cancer Progression (Review)

Oncological diseases belong to life-threatening pathologies being the second most frequent cause of morbidity and mortality after cardiovascular diseases. Clarification of carcinogenesis mechanisms makes it possible to expand the stock of tools available for prevention of critical illness accompanying this pathological condition.Nowadays, proteolytic systems of tumor microenvironment (ТМЕ) are regarded as key regulators of a tumor progression including tumor growth, invasion and metastazing. The review discusses ТМЕ structure and role in cancer progression.Recent data decipher the role of proteolytic systems in the interaction stromal cells with tumor cells in different types of cancer in humans. The most known proteolytic systems contributed to cancer progression are matrix metalloproteinase system (MMP), urokinase-type plasminogen activator system (uPA-system), various cathepsins, granzymes, and elastase. Inhibition of extracellular proteolysis in the course of an oncological process is considered an effective approach to cancer therapy