Effect of mass media intervention on HIV and AIDS related stigma and discrimination in Ethiopia.

This study was conducted to examine the effect of the Betegna radio (diary-show) programme in mitigating the tide of HIV related stigma and discrimination which are considered a prominent factor that worsens the impact of the epidemic in Ethiopia. The study employed qualitative Individual In-depth Interviews and Focus Group Discussions to generate relevant qualitative data whose analysis revealed that the programme played a significant role in empowering many members of the programme’s target audience with the necessary coping mechanisms against stigma and discriminations associated with HIV and AIDS. However, its effect was rather lower than expected because the programme was broadcast at an awkward time for some members of its target audience and it lacked the entertainment aspect.Key words: Behaviour Change, Denial, Discrimination, HIV and AIDS, Media, Stigma

Bodyweight Change and CarcassYield Performance of Somali Goats Fed with Groundnut Pod Hulls and a Mixture of Wheat Branand Mustard Seed Cake

The study was conducted at Kombolcha ATVET College, Eastern Ethiopia using 25 intact male yearling Somali goats weighing 18.4±1.5kg at the start of the experiment. The objectives of the study was to examine the effects of urea treated groundnut pod hulls and supplementation of wheat bran and mustard seed cake mixture at a ratio of 3:1, respectively at different levels on body weight change and carcass yield performance of Somali goats. A completely randomized block design was employed and the experimental animals were grouped in five blocks of five goats each based on their initial BW. The goats within a block were randomly assigned to one of the five diets. Treatment feeds consisted feeding of sole untreated groundnut pod hulls (UGNPH) (T1) adlibtum, sole urea treated (UTGNPH) (T2) adlibtum, and supplementation of the UGNPH with the concentrate mixture at graded levels of125g (T3), 250g (T4) and 375g DM/head/day (T5). Daily DM intake of UGNPH was higher (P<0.001) in T1 (407.1 g/head/day) and T3 (388.7g/head/day) compared to T4 (331.5 g/head day) and T5 (272.1 g/head/day), whereas that of UTGNPH was higher (P<0.001) for T2 (471.1 g/day/head) compared to all treatments. Total DM intake was higher (P<0.001) in supplemented groups (T3, T4, and T5) compared to non-supplemented groups (T1and T2). Goats fed sole UGNPH (T1) and UTGNH (T2) lost BW at a rate of 31 and 6 g per day, respectively, whereas supplemented goats gained BW at a rate of 18.9(T3), 40.7(T4), and 53.3g(T5)per day. Goats supplemented with concentrate had higher (P<0.001) weight of hot carcass and empty bodyweight (BW). Better dressing percentage was obtained (P<0.01) in supplemented and UTGNPH group on empty and slaughter BW basis. The result of this experiment demonstrated that urea treatment increased intake of groundnut pod hulls and decreased body weight loss as compared to the UGNPH. We recommend supplementation with 375g DM/day/head of the concentrate mixture to UGNPH based diet for small scale goat fattening programs, since neither UGNPH nor UTGNPH provided sufficient nutrients for growing goats

Determinants of mortality among under-five children admitted with severe acute malnutrition in Addis Ababa, Ethiopia.

BACKGROUND: Management of severe acute malnutrition (SAM) has been a program priority in Ethiopia, but it remains the leading cause of mortality in under-five children. Hence, this study aimed to identify the incidence density rate of mortality and determinants among under-five children with severe acute malnutrition in St. Paul's Hospital Millennium Medical College, 2012 to 2019. METHODS: A retrospective cohort study was conducted and data were collected using a structured checklist from 673 charts, of which 610 charts were included in the final analysis. The Kaplan-Meier survival curve with Log-rank test was used to estimate the survival time. Bi-variable and multi-variable Cox proportional hazard regression models were fitted to identify determinants of death. Schoenfeld residuals test was used to check a proportional hazard assumption. Goodness of fit of the final model was checked using Nelson Aalen cumulative hazard function against Cox-Snell residual. RESULTS: In this study, 61 (10%) children died making the incidence density rate of death 5.6 (95% CI: 4.4, 7.2) per 1000 child-days. Shock (Adjusted Hazard Ratio) [AHR] =3.2; 95% CI: 1.6, 6.3)), IV fluid infusion (AHR = 5.2; 95% CI: 2.4, 10.4), supplementing F100 (AHR = 0.12; 95%CI: 0.06, 0.23) and zinc (AHR = 0.45; 95% CI: 0.22, 0.93) were determinants of death. CONCLUSION: The overall proportion of deaths was within the range put forth by the Sphere standard and the national SAM management protocol. Shock and IV fluid infusion increased the hazard of death, whereas F100 & zinc were found to decrease the likelihood death. Children with SAM presented with shock should be handled carefully and IV fluids should be given with precautions

Magnitude and Associated Factors of Neural Tube Defects in Ethiopia: A Systematic Review and Meta-Analysis.

Neural tube defects remain a major problem in developing countries, but there are limited comprehensive national reports to date in Ethiopia. Therefore, this study aimed to assess the prevalence of neural tube defects and associated factors in Ethiopia. Electronic databases and other sources were used to retrieve studies. Fifteen out of 862 studies were included in the final analysis. The estimated pooled prevalence of neural tube defects among children in Ethiopia was 63.3 cases per 10 000 children. The pooled prevalence of spinal bifida, anencephaly, and encephalocele was 41.09, 18.90, and 1.07 per 10 000 children, respectively. Previous family history and unplanned pregnancy were risk factors for neural tube defects. Folic acid supplementation during the first trimester of pregnancy was found to be protective. Neural tube defects are widespread in Ethiopia. Hence, fortification of food with folic acid or folic acid supplementation during childbearing age is recommended

Observed changes in extremes of daily rainfall and temperature in Jemma Sub-Basin, Upper Blue Nile Basin, Ethiopia

Climate variability has been a threat to the socio-economic development of Ethiopia. This paper examined the changes in rainfall, minimum, and maximum temperature extremes of Jemma Sub-Basin of the Upper Blue Nile Basin for the period of 1981 to 2014. The nonparametric Mann-Kendall, seasonal Mann-Kendall, and Sen’s slope estimator were used to estimate annual trends. Ten rainfall and 12 temperature indices were used to study changes in rainfall and temperature extremes. The results showed an increasing trend of annual and summer rainfall in more than 78% of the stations and a decreasing trend of spring rainfall in most of the stations. An increase in rainfall extreme events was detected in the majority of the stations. Several rainfall extreme indices showed wetting trends in the sub-basin, whereas limited indices indicated dryness in most of the stations. Annual maximum and minimum temperature and extreme temperature indices showed warming trend in the sub-basin. Presence of extreme rainfall and a warming trend of extreme temperature indices may suggest signs of climate change in the Jemma Sub-Basin. This study, therefore, recommended the need for exploring climate induced risks and implementing appropriate climate change adaptation and mitigation strategies

Statistical bias correction of regional climate model simulations for climate change projection in the Jemma sub-basin, upper Blue Nile Basin of Ethiopia

This study evaluates bias correction methods and develops future climate scenarios using the output of a better bias correctiontechnique at the Jemma sub-basin. The performance of different bias correction techniques was evaluated using several statisticalmetrics. The bias correction methods performance under climate condition different from the current climate was also evaluatedusing the differential split sample testing (DSST) and reveals that the distribution mapping technique is valid under climatecondition different from the current climate. All bias correction methods were effective in adjusting mean monthly and annualRCM simulations of rainfall and temperature to the observed rainfall and temperature values. However, distribution mappingmethod was better in capturing the 90th percentile of observed rainfall and temperature and wet day probability of observedrainfall than other methods. As a result, we use the future (2021–2100) simulation of RCMs which are bias corrected usingdistribution mapping technique. The output of bias-adjusted RCMs unfolds a decline of rainfall, a persistent increase of temperature and an increase of extremes of rainfall and temperature in the future climate under emission scenarios of RepresentativeConcentration Pathways 4.5, 8.5 and 2.6 (RCP4.5, RCP8.5 and RCP2.6). Thus, climate adaptation strategies that can provideoptimal benefits under different climate scenarios should be developed to reduce the impact of future climate change

Longer delays in diagnosis and treatment ofpulmonary tuberculosis in pastoralist setting, Eastern Ethiopia

Purpose: This study aimed to assess the extent of patient, health system and total delays in diagnosis and treatment of pulmonary tuberculosis (TB) in Somali pastoralist setting, Ethiopia. Patients and Methods: A cross-sectional study among 444 confirmed new pulmonary TB patients aged ≥15 years in 5 TB care units was conducted between December 2017 and October 2018. Data were collected using a structured questionnaire and record review. We measured delays from symptom onset to provider visit, provider visit to diagnosis and diagnosis to treatment initiation. Delays were summarized using median days. Mann- Whitney and Kruskal-Wallis tests were used to compare delays between categories of explanatory variables. The Log-binomial regression model was used to reveal factors associated with health system delay ≥15 days, presented in adjusted prevalence ratio (APR) with 95% confidence interval (CI). Results: The median age of patients was 30 years, ranged from 15 to 82. The majority (62.4%) were male, and nearly half (46.4%) were pastoralists. The median patient, health system and total delays were 30 (19-48.5), 14 (4.5-29.5) and 50 (35-73.5) days, respec-tively. The median patient delay (35.5 days) and total delay (58.5 days) among pastoralists were substantially higher than the equivalent delays among non-pastoralists [p<0.001]. Of all, 3.8% of patients (16 of 18 were pastoralists) delayed longer than 6 months without initiating treatment. Factors associated with health system delay ≥15 days were mild symptoms [APR (95% CI) = 1.4 (1.1-1.7)], smear-negativity [APR (95% CI) = 1.2 (1.01- 1.5)], first visit to health centers [APR (95% CI) = 1.6 (1.3-2.0)] and multiple provider contacts [APR (95% CI) = 5.8 (3.5-9.6)]. Conclusion: Delay in diagnosis and treatment remains a major challenge of tuberculosis control targets in pastoralist settings of Ethiopia. Efforts to expand services tailored to transhumance patterns and diagnostic capacity of primary healthcare units need to be prioritized. © 2020 Getnet et al.Purpose: This study aimed to assess the extent of patient, health system and total delays in diagnosis and treatment of pulmonary tuberculosis (TB) in Somali pastoralist setting, Ethiopia. Patients and Methods: A cross-sectional study among 444 confirmed new pulmonary TB patients aged ≥15 years in 5 TB care units was conducted between December 2017 and October 2018. Data were collected using a structured questionnaire and record review. We measured delays from symptom onset to provider visit, provider visit to diagnosis and diagnosis to treatment initiation. Delays were summarized using median days. Mann- Whitney and Kruskal-Wallis tests were used to compare delays between categories of explanatory variables. The Log-binomial regression model was used to reveal factors associated with health system delay ≥15 days, presented in adjusted prevalence ratio (APR) with 95% confidence interval (CI). Results: The median age of patients was 30 years, ranged from 15 to 82. The majority (62.4%) were male, and nearly half (46.4%) were pastoralists. The median patient, health system and total delays were 30 (19-48.5), 14 (4.5-29.5) and 50 (35-73.5) days, respec-tively. The median patient delay (35.5 days) and total delay (58.5 days) among pastoralists were substantially higher than the equivalent delays among non-pastoralists [p<0.001]. Of all, 3.8% of patients (16 of 18 were pastoralists) delayed longer than 6 months without initiating treatment. Factors associated with health system delay ≥15 days were mild symptoms [APR (95% CI) = 1.4 (1.1-1.7)], smear-negativity [APR (95% CI) = 1.2 (1.01- 1.5)], first visit to health centers [APR (95% CI) = 1.6 (1.3-2.0)] and multiple provider contacts [APR (95% CI) = 5.8 (3.5-9.6)]. Conclusion: Delay in diagnosis and treatment remains a major challenge of tuberculosis control targets in pastoralist settings of Ethiopia. Efforts to expand services tailored to transhumance patterns and diagnostic capacity of primary healthcare units need to be prioritized. © 2020 Getnet et al

Evaluation of regional climate models performance in simulating rainfall climatology of Jemma sub-basin, Upper Blue Nile Basin, Ethiopia

This study examines the performance of 10 Regional Climate Model (RCM) outputs which are dynamically downscaled from the fifth phase of Coupled Model Inter-comparison Project (CMIP5) GCMs using different RCMs parameterization approaches. The RCMs are evaluated based on their ability to reproduce the magnitude and pattern of monthly and annual rainfall, characteristics of rainfall events and variability related to Sea Surface Temperature (SST) for the period 1981–2005. The outputs of all RCMs showed wet bias, particularly in the higher elevation areas of the sub-basin. Wet bias of annual rainfall ranges from 9.60% in CCLM4 (HadGEM2-ES) model to 110.9% in RCA4 (EC-EARTH) model. JJAS (June-September) rainfall is also characterized by wet bias ranges from 0.76% in REMO (MPI-ESM-LR) model to 100.7% in RCA4 (HadGEM2-ES) model. GCMs that were dynamically downscaled through REMO (Max Planck Institute) and CCLM4 (Climate Limited-Area Modeling) performed better in capturing the rainfall climatology and distribution of rainfall events. However, GCMs dynamically downscaled using RCA4 (SMHI Rossby Center Regional Atmospheric Model) were characterized by overestimation and there are more extreme rainfall events in the cumulative distribution. Most of the RCMs’ rainfall over the sub-basin showed a teleconnection with Sea Surface Temperature (SST) of CMIP5 GCMs in the Pacific and Indian Oceans, but weak. The ensemble mean of all 10 RCMs simulations was superior in capturing the seasonal pattern of the rainfall and had better correlation with observed annual (Correl = 0.6) and JJAS season rainfall (Correl = 0.5) than any single model (S-RCM). We recommend using GCMs downscaled using REMO and CCLM4 RCMs and stations based statistical bias correction to manage elevation based biases of RCMs in the Upper Blue Nile Basin, specifically in the Jemma sub-basin

Metabolic syndrome among children and adolescents in low and middle income countries: a systematic review and meta-analysis.

BackgroundMetabolic syndrome (MetS) is a clustering of cardiovascular risk factors, which is rising in the low and middle income countries (LMICs). There are various studies with inconsistent findings that are inconclusive for policy makers and program planners. Thus, this systematic review and meta-analysis aimed at estimating the pooled prevalence of MetS and its components in LMICs.MethodsElectronic searches were conducted in international databases including PubMed, Web of Science, EMBASE (Elsevier), Scopus, CINAHL (EBSCOhost), Science direct (Elsevier), Food Science and Technology Abstracts (FSTA), Global Health and Medline, and other sources (World Cat, Google Scholar, and Google). The pooled estimates were computed in the random effect model. The pooled prevalence was computed using the three diagnostic methods (IDF, ATP III and de Ferranti). Publication bias was verified using funnel plot and Egger's regression test. Subgroup and sensitivity analysis were performed to identify the possible sources of heterogeneity among the included studies.ResultIn this study, 142,142 children and adolescents from 76 eligible articles were included to compute the pooled prevalence of MetS and its components in LMCIs. MeTs among overweight and obese population was computed from 20 articles with the pooled prevalence of 24.09%, 36.5%, and 56.32% in IDF, ATP III and de Ferranti criteria, respectively. Similarly, a total of 56 articles were eligible to compute the pooled prevalence of MetS in the general population of children and adolescents. Hence, Mets was found in 3.98% (IDF), 6.71% (ATP III) and 8.91% (de Ferranti) of study subjects. Regarding the components of MetS, abdominal obesity was the major component in overweight and obese population and low HDL-C was the most common component in the general population. This study also revealed that males were highly affected by MetS than females.ConclusionThis study illustrates that MetS among children and adolescents is an emerging public health challenge in LMICs, where the prevalence of obesity is on the move. Preventive strategies such as community and school based intervention need to be designed. Promoting physical activities and healthy eating behaviors could avert this problem

Comparative Analysis of V-Akt Murine Thymoma Viral Oncogene Homolog 3 (AKT3) Gene between Cow and Buffalo Reveals Substantial Differences for Mastitis

AKT3 gene is a constituent of the serine/threonine protein kinase family and plays a crucial role in synthesis of milk fats and cholesterol by regulating activity of the sterol regulatory element binding protein (SREBP). AKT3 is highly conserved in mammals and its expression levels during the lactation periods of cattle are markedly increased. AKT3 is highly expressed in the intestine followed by mammary gland and it is also expressed in immune cells. It is involved in the TLR pathways as effectively as proinflammatory cytokines. The aims of this study were to investigate the sequences differences between buffalo and cow. Our results showed that there were substantial differences between buffalo and cow in some exons and noteworthy differences of the gene size in different regions. We also identified the important consensus sequence motifs, variation in 2000 upstream of ATG, substantial difference in the “3′UTR” region, and miRNA association in the buffalo sequences compared with the cow. In addition, genetic analyses, such as gene structure, phylogenetic tree, position of different motifs, and functional domains, were performed to establish their correlation with other species. This may indicate that a buffalo breed has potential resistance to disease, environment changes, and airborne microorganisms and some good production and reproductive traits