5,689 research outputs found
What can a mean-field model tell us about the dynamics of the cortex?
In this chapter we examine the dynamical behavior of a spatially homogeneous two-dimensional model of the cortex that incorporates membrane potential, synaptic flux rates and long- and short-range synaptic input, in two spatial dimensions, using parameter sets broadly realistic of humans and rats. When synaptic dynamics are included, the steady states may not be stable. The bifurcation structure for the spatially symmetric case is explored, identifying the positions of saddle–node and sub- and supercritical Hopf instabilities. We go beyond consideration of small-amplitude perturbations to look at nonlinear dynamics. Spatially-symmetric (breathing mode) limit cycles are described, as well as the response to spatially-localized impulses. When close to Hopf and saddle–node bifurcations, such impulses can cause traveling waves with similarities to the slow oscillation of slow-wave sleep. Spiral waves can also be induced. We compare model dynamics with the known behavior of the cortex during natural and anesthetic-induced sleep, commenting on the physiological significance of the limit cycles and impulse responses
Infrared Variability of Two Dusty White Dwarfs
The most heavily polluted white dwarfs often show excess infrared radiation
from circumstellar dust disks, which are modeled as a result of tidal
disruption of extrasolar minor planets. Interaction of dust, gas, and
disintegrating objects can all contribute to the dynamical evolution of these
dust disks. Here, we report on two infrared variable dusty white dwarfs, SDSS
J1228+1040 and G29-38. For SDSS J1228+1040, compared to the first measurements
in 2007, the IRAC [3.6] and [4.5] fluxes decreased by 20% by 2014 to a level
also seen in the recent 2018 observations. For G29-38, the infrared flux of the
10 m silicate emission feature became 10% stronger between 2004 and 2007,
We explore several scenarios that could account for these changes, including
tidal disruption events, perturbation from a companion, and runaway accretion.
No satisfactory causes are found for the flux drop in SDSS J1228+1040 due to
the limited time coverage. Continuous tidal disruption of small planetesimals
could increase the mass of small grains and concurrently change the strength of
the 10 m feature of G29-38. Dust disks around white dwarfs are actively
evolving and we speculate that there could be different mechanisms responsible
for the temporal changes of these disks.Comment: ApJ, in pres
The Effect of Thermal Hydrolysis Pretreatment on the Anaerobic Degradation of Nonylphenol and Short-Chain Nonylphenol Ethoxylates in Digested Biosolids
The presence of micropollutants can be a concern for land application of biosolids. Of particular interest are nonylphenol diethoxylate (NP2EO), nonylphenol monoethoxylate (NP1EO), and nonylphenol (NP), collectively referred to as NPE, which accumulate in anaerobically digested biosolids and are subject to regulation based on the environmental risks associated with them. Because biosolids are a valuable nutrient resource, it is essential that we understand how various treatment processes impact the fate of NPE in biosolids. Thermal hydrolysis (TH) coupled with mesophilic anaerobic digestion (MAD) is an advanced digestion process that destroys pathogens in biosolids and increases methane yields and volatile solids destruction. We investigated the impact of thermal hydrolysis pretreatment on the subsequent biodegradation of NPE in digested biosolids. Biosolids were treated with TH, anaerobic digestion, and aerobic digestion in laboratory-scale reactors, and NPE were analyzed in the influent and effluent of the digesters. NP2EO and NP1EO have been observed to degrade to the more estrogenic NP under anaerobic conditions; therefore, changes in the ratio of NP:NPE were of interest. The increase in NP:NPE following MAD was 56%; the average increase of this ratio in four sets of TH-MAD samples, however, was only 24.6 ± 3.1%. In addition, TH experiments performed in pure water verified that, during TH, the high temperature and pressure alone did not directly destroy NPE; TH experiments with NP added to sludge also showed that NP was not destroyed by the high temperature and pressure of TH when in a more complex sludge matrix. The post-aerobic digestion phases removed NPE, regardless of whether TH pretreatment occurred. This research indicates that changes in biosolids processing can have impacts beyond just gas production and solids destruction
Nkx2-5 and Sarcospan genetically interact in the development of the muscular ventricular septum of the heart
The muscular ventricular septum separates the flow of oxygenated and de-oxygenated blood in air-breathing vertebrates. Defects within it, termed muscular ventricular septal defects (VSDs), are common, yet less is known about how they arise than rarer heart defects. Mutations of the cardiac transcription factor NKX2-5 cause cardiac malformations, including muscular VSDs. We describe here a genetic interaction between Nkx2-5 and Sarcospan (Sspn) that affects the risk of muscular VSD in mice. Sspn encodes a protein in the dystrophin-glycoprotein complex. Sspn knockout (Sspn(KO)) mice do not have heart defects, but Nkx2-5(+/−)/Sspn(KO) mutants have a higher incidence of muscular VSD than Nkx2-5(+/−) mice. Myofibers in the ventricular septum follow a stereotypical pattern that is disrupted around a muscular VSD. Subendocardial myofibers normally run in parallel along the left ventricular outflow tract, but in the Nkx2-5(+/−)/Sspn(KO) mutant they commonly deviate into the septum even in the absence of a muscular VSD. Thus, Nkx2-5 and Sspn act in a pathway that affects the alignment of myofibers during the development of the ventricular septum. The malalignment may be a consequence of a defect in the coalescence of trabeculae into the developing ventricular septum, which has been hypothesized to be the mechanistic basis of muscular VSDs
A Candidate Young Massive Planet in Orbit around the Classical T Tauri Star CI Tau
The ~2 Myr old classical T Tauri star CI Tau shows periodic variability in
its radial velocity (RV) variations measured at infrared (IR) and optical
wavelengths. We find that these observations are consistent with a massive
planet in a ~9-day period orbit. These results are based on 71 IR RV
measurements of this system obtained over 5 years, and on 26 optical RV
measurements obtained over 9 years. CI Tau was also observed photometrically in
the optical on 34 nights over ~one month in 2012. The optical RV data alone are
inadequate to identify an orbital period, likely the result of star spot and
activity induced noise for this relatively small dataset. The infrared RV
measurements reveal significant periodicity at ~9 days. In addition, the full
set of optical and IR RV measurements taken together phase coherently and with
equal amplitudes to the ~9 day period. Periodic radial velocity signals can in
principle be produced by cool spots, hot spots, and reflection of the stellar
spectrum off the inner disk, in addition to resulting from a planetary
companion. We have considered each of these and find the planet hypothesis most
consistent with the data. The radial velocity amplitude yields an Msin(i) of
~8.1 M_Jup; in conjunction with a 1.3 mm continuum emission measurement of the
circumstellar disk inclination from the literature, we find a planet mass of
~11.3 M_Jup, assuming alignment of the planetary orbit with the disk.Comment: 61 pages, 13 figures, accepted for publication in The Astrophysical
Journa
High-Angular Resolution Dust Polarization Measurements: Shaped B-field Lines in the Massive Star Forming Region Orion BN/KL
We present observational results of the thermal dust continuum emission and
its linear polarization in one of the nearest massive star-forming sites Orion
BN/KL in Orion Molecular Cloud-1. The observations were carried out with the
Submillimeter Array. With an angular resolution of 1" (~2 mpc; 480 AU), we have
detected and resolved the densest cores near the BN/KL region. At a wavelength
of ~870 micron, the polarized dust emission can be used to trace the structure
of the magnetic field in this star-forming core. The dust continuum appears to
arise from a V-shaped region, with a cavity nearly coincident with the center
of the explosive outflows observed on larger scales. The position angles
(P.A.s) of the observed polarization vary significantly by a total of about 90
degree but smoothly, i.e., curl-like, across the dust ridges. Such a
polarization pattern can be explained with dust grains being magnetically
aligned instead of mechanically with outflows, since the latter mechanism would
cause the P.A.s to be parallel to the direction of the outflow, i.e.,
radial-like. The magnetic field projected in the plane of sky is therefore
derived by rotating the P.A.s of the polarization by 90 degree. We find an
azimuthally symmetric structure in the overall magnetic field morphology, with
the field directions pointing toward 2.5" west to the center of the explosive
outflows. We also find a preferred symmetry plane at a P.A. of 36 degree, which
is perpendicular to the mean magnetic field direction (120 degree) of the 0.5
pc dust ridge. Two possible interpretations of the origin of the observed
magnetic field structure are discussed.Comment: 27 pages, 7 figures; ApJ in pres
The Formaldehyde Masers in NGC 7538 and G29.96-0.02: VLBA, MERLIN, and VLA Observations
The 6 cm formaldehyde (H2CO) maser sources in the compact HII regions NGC
7538-IRS1 and G29.96-0.02 have been imaged at high resolution (beams < 50 mas).
Using the VLBA and MERLIN, we find the angular sizes of the NGC 7538 masers to
be ~10 mas (30 AU) corresponding to brightness temperatures ~10^8 K. The
angular sizes of the G29.96-0.02 masers are ~20 mas (130 AU) corresponding to
brightness temperatures ~10^7 K. Using the VLA, we detect 2 cm formaldehyde
absorption from the maser regions. We detect no emission in the 2 cm line,
indicating the lack of a 2 cm maser and placing limits on the 6 cm excitation
process. We find that both NGC 7538 maser components show an increase in
intensity on 5-10 year timescales while the G29.96-0.02 masers show no
variability over 2 years. A search for polarization provides 3-sigma upper
limits of 1% circularly polarized and 10% linearly polarized emission in NGC
7538 and of 15% circularly polarized emission in G29.96-0.02. A pronounced
velocity gradient of 28 km/s/arcsecond (1900 km/s/pc) is detected in the NGC
7538 maser gas.Comment: accepted to ApJ, 15 figures, 11 table
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