Clinical surveillance of thrombotic microangiopathies in Scotland, 2003-2005

The prevalence, incidence and outcomes of haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopaenic purpura (TTP) are not well established in adults or children from prospective studies. We sought to identify both outcomes and current management strategies using prospective, national surveillance of HUS and TTP, from 2003 to 2005 inclusive. We also investigated the links between these disorders and factors implicated in the aetiology of HUS and TTP including infections, chemotherapy, and immunosuppression. Most cases of HUS were caused by verocytotoxin-producing Escherichia coli (VTEC), of which serotype O157 predominated, although other serotypes were identified. The list of predisposing factors for TTP was more varied although use of immunosuppressive agents and severe sepsis, were the most frequent precipitants. The study demonstrates that while differentiating between HUS and TTP is sometimes difficult, in most cases the two syndromes have quite different predisposing factors and clinical parameters, enabling clinical and epidemiological profiling for these disorders

Mouse embryos in culture: models for understanding diabetes-induced embryopathies and gene function.

Both the metabolic studies on diabetes and the genetic studies using antisense oligodeoxynucleotides clearly demonstrate the importance and usefulness of rodent whole embryo culture. Without this technique, these studies would be impossible and, consequently, our knowledge of both normal and abnormal development would not be as advanced as it is today. The culture system fills a unique niche in studies in the fields of developmental biology and teratology and these sciences would have been less well served without Dr. New's contribution

Radiolabelling of Corynebacterium parvum and its distribution in mice.

Corynebacterium parvum was labelled by growing live bacteria in the presence of [3H]thymidine. The bacteria were killed by formalin, washed thoroughly and resuspended at a concentration of 7 mg dry weight/ml. An activity of 1-6 X 10(5) ct/min/0-1 ml was obtained. The biological properties (inhibition of tumour growth and hepatosplenomegaly) of the labelled C. parvum were compared with those of commercially available vaccine, and were found to be similar. Labelled C. parvum was injected i.v., i.p., or s.c. into normal C57BL mice and the localization of activity determined at 4 h and 1,3,7 and 14 days after injection. After i.v. or i.p. injection, highest counts were recorded in the liver. Moderate activity was found in the spleen, lungs and small gut. After s.c. injection, the majority of radioactive label was detected at the site of injection and little found in other tissues. The distribution of injected C. parvum was also studied in mice bearing Lewis tumour, and was found to be similar to that in normal mice. Moderate amounts of labelled C. parvum were recovered from tumour. There appeared to be no relationship between the antitumour effect of C. parvum given by a particular route of injection and the concentration of C. parvum recovered from the tumour

Further Observational Evidence for a Critical Ionising Luminosity in Active Galaxies

We report the results of a survey for HI 21-cm absorption at redshifts of z > 2.6 in a new sample of radio sources with the Green Bank and Giant Metrewave Radio Telescopes. From a total of 25 targets, we report zero detections in the 16 for which optical depth limits could be obtained. Based upon the detection rate for z > 0.1 associated absorption, we would expect approximately four detections. Of the 11 which have previously not been searched, there is sufficient source-frame optical/ultra-violet photometry to determine the ionising photon rate for four. Adding these to the literature, the hypothesis that there is a critical rate of logQ = 56 ionising photons per second is now significant at ~7 sigma. This reaffirms our assertion that searching z > 3 active galaxies for which optical redshifts are available selects sources in which the ultra-violet luminosity is sufficient to ionise all of the neutral gas in the host galaxy.Comment: Accepted by MNRA

The Sub-parsec Scale Radio Properties of Southern Starburst Galaxies. I. Supernova Remnants, the Supernova Rate, and the Ionised Medium in the NGC 253 Starburst

Wide-field, very long baseline interferometry (VLBI) observations of the nearby starburst galaxy NGC 253, obtained with the Australian Long Baseline Array (LBA), have produced a 2.3 GHz image with a maximum angular resolution of 15 mas (0.3 pc). Six sources were detected, all corresponding to sources identified in higher frequency (>5 GHz) VLA images. One of the sources, supernova remnant 5.48-43.3, is resolved into a shell-like structure approximately 90 mas (1.7 pc) in diameter. From these data and data from the literature, the spectra of 20 compact radio sources in NGC 253 were modelled and found to be consistent with free-free absorbed power laws. Broadly, the free-free opacity is highest toward the nucleus but varies significantly throughout the nuclear region (tau_0 ~ 1->20), implying that the overall structure of the ionised medium is clumpy. Of the 20 sources, nine have flat intrinsic spectra associated with thermal radio emission and the remaining 11 have steep intrinsic spectra, associated with synchrotron emission from supernova remnants. A supernova rate upper limit of 2.4 yr^-1 is determined for the inner 320 pc region of the galaxy at the 95% confidence level, based on the lack of detection of new sources in observations spanning almost 17 years and a simple model for the evolution of supernova remnants. A supernova rate of >0.14 (v/10^4) yr^-1 is implied from estimates of supernova remnant source counts, sizes and expansion rates, where v is the radial expansion velocity of the supernova remnant in km s^-1. A star formation rate of 3.4 (v/10^4) < SFR(M<=5Msun) < 59 Msun yr^-1 has been estimated directly from the supernova rate limits and is of the same order of magnitude as rates determined from integrated FIR and radio luminosities.Comment: Accepted by the Astronomical Journal. 34 pages, 6 figures; fixed typos in assumed expansion velocit

Radio Sources in Low-Luminosity Active Galactic Nuclei. I. VLA Detections of Compact, Flat-Spectrum Cores

We report a 0.2" resolution, 15 GHz survey of a sample of 48 low-luminosity active galactic nuclei with the Very Large Array. Compact radio emission has been detected in 57% (17 of 30) of LINERs and low-luminosity Seyferts, at least 15 of which have a flat to inverted radio spectrum (alpha > -0.3). The compact radio cores are found in both type 1 (i.e. with broad Halpha) and type 2 (without broad Halpha) nuclei. The 2 cm radio power is significantly correlated with the emission-line ([OI] lambda6300) luminosity. While the present observations are consistent with the radio emission originating in star-forming regions, higher resolution radio observations of 10 of the detected sources, reported in a companion paper (Falcke et al. 2000), show that the cores are very compact (= 10^8K) and probably synchrotron self-absorbed, ruling out a starburst origin. Thus, our results suggest that at least 50% of low-luminosity Seyferts and LINERs in the sample are accretion powered, with the radio emission presumably coming from jets or advection-dominated accretion flows. We have detected only 1 of 18 `transition' (i.e. LINER + HII) nuclei observed, indicating their radio cores are significantly weaker than those of `pure' LINERs.Comment: To appear in the Astrophysical Journal, October 20, 200

SUMSS: A Wide-Field Radio Imaging Survey of the Southern Sky. II. The Source Catalogue

This paper is the second in a series describing the Sydney University Molonglo Sky Survey (SUMSS) being carried out at 843MHz with the Molonglo Observatory Synthesis Telescope (MOST). The survey will consist of ~590 4.3deg. x 4.3deg. mosaic images with 45"x45"cosec|dec.| resolution, and a source catalogue. In this paper we describe the initial release (version 1.0) of the source catalogue consisting of 107,765 radio sources made by fitting elliptical gaussians in 271 SUMSS mosaics to a limiting peak brightness of 6mJy/beam at dec.-50deg.. The catalogue covers approximately 3500deg^2 of the southern sky with dec.<=-30deg., about 43 per cent of the total survey area. Positions in the catalogue are accurate to within 1"-2" for sources with peak brightness A>=20mJy/beam and are always better than 10". The internal flux density scale is accurate to within 3 per cent. Image artefacts have been classified using a decision tree, which correctly identifies and rejects spurious sources in over 96 per cent of cases. Analysis of the catalogue shows that it is highly uniform and is complete to 8mJy at dec.-50deg.. In this release of the catalogue about 7000 sources are found in the overlap region with the NRAO VLA Sky Survey (NVSS) at 1.4GHz. We calculate a median spectral index of alpha=-0.83 between 1.4GHz and 843MHz. This version of the catalogue will be released via the World Wide Web with future updates as new mosaics are released.Comment: 15 pages, 15 figures, accepted by MNRAS, Catalogue at http://www.astrop.physics.usyd.edu.au/sumssca