Preferential mobilization and egress of Type 1 and Type 3 innate lymphocytes in response to exercise and hypoxia

The study examined the effect of exercise and hypoxia on the mobilization and egress of innate lymphocytes (ILCs) and adaptive T cell populations in the blood. The ILCs have emerged as a critical population of cells in immune regulation at mucosal surfaces in animals and humans. Eleven healthy male subjects performed (i) 45 min of exercise at 50% VO2 peak on a cycle ergometer under normoxia and (ii) hypoxia, or (iii) while resting in hypoxia. Blood samples were obtained pre-exercise, immediately post-exercise and 60 min post-exercise and were analyzed by flow cytometry to examine the type 1 and type 3 ILCs and CD4+ and CD8+ naive and memory cell populations. There was a significant increase in the number of type 1 (NK cells) and type 3 ILC22 cells in the blood in response to exercise under normal oxygen conditions followed by a significant egress of these cells following the cessation of exercise. Exercise performed under hypoxic conditions abrogated the mobilization response of NK cells and ILC22 cells. Type 3 LTi cells were mobilized into the blood only under hypoxic rest conditions. No significant changes were observed when we analysed total CD4+ and CD8+T cell populations or the naive and memory subsets. This study highlights that distinct innate populations are mobilised under different environmental conditions and types of stress

Frustrated multiband superconductivity

We show that a clean multiband superconductor may display one or several phase transitions with increasing temperature from or to frustrated configurations of the relative phases of the superconducting order parameters. These transitions may occur when more than two bands are involved in the formation of the superconducting phase and when the number of repulsive interband interactions is odd. These transitions are signalled by slope changes in the temperature dependence of the superconducting gaps.Comment: 5 pages, 3 figure

Broken time-reversal symmetry in Josephson junction involving two-band superconductors

A novel time-reversal symmetry breaking state is found theoretically in the Josephson junction between the two-gap superconductor and the conventional s-wave superconductor. This occurs due to the frustration between the three order parameters analogous to the two antiferromagnetically coupled XY-spins put under a magnetic field. This leads to the interface states with the energies inside the superconducting gap. Possible experimental observations of this state with broken time-reversal symmetry are discussed.Comment: 9 pages, 1 figur

Probing spacetime foam with extragalactic sources

Due to quantum fluctuations, spacetime is probably ``foamy'' on very small scales. We propose to detect this texture of spacetime foam by looking for core-halo structures in the images of distant quasars. We find that the Very Large Telescope interferometer will be on the verge of being able to probe the fabric of spacetime when it reaches its design performance. Our method also allows us to use spacetime foam physics and physics of computation to infer the existence of dark energy/matter, independent of the evidence from recent cosmological observations.Comment: LaTeX, 11 pages, 1 figure; version submitted to PRL; several references added; very useful comments and suggestions by Eric Perlman incorporate

From computation to black holes and space-time foam

We show that quantum mechanics and general relativity limit the speed $\tilde{\nu}$ of a simple computer (such as a black hole) and its memory space $I$ to \tilde{\nu}^2 I^{-1} \lsim t_P^{-2}, where $t_P$ is the Planck time. We also show that the life-time of a simple clock and its precision are similarly limited. These bounds and the holographic bound originate from the same physics that governs the quantum fluctuations of space-time. We further show that these physical bounds are realized for black holes, yielding the correct Hawking black hole lifetime, and that space-time undergoes much larger quantum fluctuations than conventional wisdom claims -- almost within range of detection with modern gravitational-wave interferometers.Comment: A misidentification of computer speeds is corrected. Our results for black hole computation now agree with those given by S. Lloyd. All other conclusions remain unchange

Observations of Microwave Continuum Emission from Air Shower Plasmas

We investigate a possible new technique for microwave measurements of ultra-high energy cosmic ray (UHECR) extensive air showers which relies on detection of expected continuum radiation in the microwave range, caused by free-electron collisions with neutrals in the tenuous plasma left after the passage of the shower. We performed an initial experiment at the AWA (Argonne Wakefield Accelerator) laboratory in 2003 and measured broadband microwave emission from air ionized via high energy electrons and photons. A follow-up experiment at SLAC (Stanford Linear Accelerator Center) in summer of 2004 confirmed the major features of the previous AWA observations with better precision and made additional measurements relevant to the calorimetric capabilities of the method. Prompted by these results we built a prototype detector using satellite television technology, and have made measurements indicating possible detection of cosmic ray extensive air showers. The method, if confirmed by experiments now in progress, could provide a high-duty cycle complement to current nitrogen fluorescence observations of UHECR, which are limited to dark, clear nights. By contrast, decimeter microwave observations can be made both night and day, in clear or cloudy weather, or even in the presence of moderate precipitation.Comment: 15 pages, 13 figure

Spin polarized liquid 3He

We have employed the constrained variational method to study the influence of spin polarization on the ground state properties of liquid $^3{\rm He}$. The spin polarized phase, we have found, has stronger correlation with respect to the unpolarized phase. It is shown that the internal energy of liquid $^3{\rm He}$ increases by increasing polarization with no crossing point between polarized and unpolarized energy curves over the liquid density range. The obtained internal energy curves show a bound state, even in the case of fully spin polarized matter. We have also investigated the validity of using a parabolic formula for calculating the energy of spin polarized liquid $^3{\rm He}$. Finally, we have compared our results with other calculations.Comment: 16 pages, 6 figure

Supersymmetry in models with strong on-site Coulomb repulsion - application to t-J model

A supersymmetric way of imposing the constraint of no double occupancy in models with strong on-site Coulomb repulsion is presented in this paper. In this formulation the physical operators in the constrainted Hilbert space are invariant under local unitary transformations mixing boson and fermion representations. As an illustration the formulation is applied to the $t-J$ model. The model is studied in the mean-field level in the J=0 limit where we show how both the slave-boson and slave-fermion formulations are included naturally in the present approach and how further results beyond both approaches are obtained.Comment: 12 pages, Latex file, 1 figur