5 research outputs found
Disease-Toxicant Interactions in Manganese Exposed Huntington Disease Mice: Early Changes in Striatal Neuron Morphology and Dopamine Metabolism
- Author
- A Gaeta
- A Takeda
- A Takeda
- A van Dellen
- Aaron B. Bowman
- AB Bowman
- AG Carter
- AJ Hannan
- AJ Milnerwood
- AN Ortiz
- AN Ortiz
- BB Williams
- BB Williams
- BG Garcia
- BG Garcia
- BW Mel
- C Schmidt-Hieber
- CA Dodd
- CS Woolley
- CW Olanow
- CW Olanow
- D Milatovic
- D Tsay
- DA Sholl
- David C. Rubinsztein
- DB Calne
- EB Bloss
- EJ Slow
- G Gianutsos
- G Graveland
- G Huntington's Disease Collaborative Research
- GD Stanwood
- GF Kwakye
- GJ Klapstein
- GW Lipe
- H Duan
- J Nithianantharajah
- JA Bibb
- JA Markham
- JA Roth
- JB Carroll
- JC Magee
- JD Grill
- Jennifer L. Madison
- JH Cha
- JM Van Raamsdonk
- JP Vonsattel
- KM Erikson
- KM Harmon
- L Menalled
- L Vidal
- M Aschner
- M Aschner
- M Day
- M Qin
- MA Johnson
- MF Struve
- MH Anca
- Michael Aschner
- Michal Wegrzynowicz
- MP Duyao
- MS Golub
- N Autissier
- N Georgiou
- NC Burton
- NS Wexler
- OC Stine
- P Guidetti
- P Vetter
- PJ Kontur
- PK Pal
- RA Yokel
- RH Gwiazda
- RJ Ferrante
- RR Brinkman
- S Kawaguchi
- SE Andrew
- SH Reaney
- SM de la Monte
- SV Kusnoor
- SW Jaslove
- T Vezer
- TH McNeill
- TL Spires
- TR Guilarte
- TR Guilarte
- TS Tang
- U Dydak
- ZF Mainen
- Publication venue
- Public Library of Science
- Publication date
- 17/02/2012
- Field of study
YAC128 Huntington's disease (HD) transgenic mice accumulate less manganese (Mn) in the striatum relative to wild-type (WT) littermates. We hypothesized that Mn and mutant Huntingtin (HTT) would exhibit gene-environment interactions at the level of neurochemistry and neuronal morphology. Twelve-week-old WT and YAC128 mice were exposed to MnCl2-4H2O (50 mg/kg) on days 0, 3 and 6. Striatal medium spiny neuron (MSN) morphology, as well as levels of dopamine (DA) and its metabolites (which are known to be sensitive to Mn-exposure), were analyzed at 13 weeks (7 days from initial exposure) and 16 weeks (28 days from initial exposure). No genotype-dependent differences in MSN morphology were apparent at 13 weeks. But at 16 weeks, a genotype effect was observed in YAC128 mice, manifested by an absence of the wild-type age-dependent increase in dendritic length and branching complexity. In addition, genotype-exposure interaction effects were observed for dendritic complexity measures as a function of distance from the soma, where only YAC128 mice were sensitive to Mn exposure. Furthermore, striatal DA levels were unaltered at 13 weeks by genotype or Mn exposure, but at 16 weeks, both Mn exposure and the HD genotype were associated with quantitatively similar reductions in DA and its metabolites. Interestingly, Mn exposure of YAC128 mice did not further decrease DA or its metabolites versus YAC128 vehicle exposed or Mn exposed WT mice. Taken together, these results demonstrate Mn-HD disease-toxicant interactions at the onset of striatal dendritic neuropathology in YAC128 mice. Our results identify the earliest pathological change in striatum of YAC128 mice as being between 13 to 16 weeks. Finally, we show that mutant HTT suppresses some Mn-dependent changes, such as decreased DA levels, while it exacerbates others, such as dendritic pathology
Risk-Based Comparability Assessment for Monoclonal Antibodies During Drug Development: A Clinical Pharmacology Perspective
- Author
- A Ambrogelly
- A Bertolotti-Ciarlet
- A Chioato
- A Kuriakose
- A Marachelian
- A Planinc
- AJ Chirino
- AJ Jones
- Alexander Jacobi
- AM Goetze
- Amarnath Sharma
- AS Rosenberg
- B Sharma
- B Vezer
- B Wang
- C Han
- C Xu
- CA Boswell
- CJ Wynne
- D Reusch
- Di Chen
- ED Deeks
- EM Moussa
- F Gruia
- F Higel
- F Torkashvand
- FW Brambell
- G Jiang
- G Walsh
- H Liu
- H Pan
- H Schellekens
- H Struemper
- HW Schroeder Jr
- J Liu
- J Stracke
- J Vlasak
- JM Benson
- JM Hayes
- JM Woof
- JN Arnold
- JS Bee
- JT Ryman
- K Brorson
- L Huang
- L Liu
- L Sanchez
- LA Khawli
- LK Hmiel
- M Federici
- M Yu
- MJ Coloma
- P Hossler
- R Jefferis
- RM Lewis
- S Cohen
- SivaNaga S. Anumolu
- SK Singh
- T Igawa
- TA Millward
- TJ Kamerzell
- TT Kuo
- V Brinks
- W Wang
- W Wang
- W Wang
- W Wang
- WS Putnam
- X Gao
- Y Zheng
- Y Zhuang
- Yanli Zhuang
- Z Xu
- Zhenhua Xu
- Publication venue
- 'American Association of Pharmaceutical Scientists (AAPS)'
- Publication date
- Field of study
Issues for a Neo-Polanyian Research Agenda in Economic Sociology
- Author
- Amin A.
- Amin S.
- Berthoud G.
- Block F.
- Bognar J.
- Bourdieu P.
- Boyer R.
- Cangiani M.
- Dalton G.
- Dalton G.
- DiMaggio P.
- Fourie F. C.
- Frenzen J.
- Granovetter M.
- Granovetter M.
- Granovetter M.
- Granovetter M.
- Harvey M.
- Harvey M.
- Harvey M.
- Helleiner E.
- Helleiner E.
- Hirsch P.
- Hodgson G. M.
- Hodgson G. M.
- Hodgson G. M.
- Hodgson G. M.
- Hodgson G. M.
- Hodgson G. M.
- Hodgson G. M.
- Hodgson G. M.
- Hopkins T. K.
- Jessop B.
- Kirman A.
- Konstantinov Y.
- Kregel J. A.
- Mason E.
- McRobbie K.
- McRobbie K.
- Mendell M.
- Mizruchi M. S.
- MĂĽller B.
- North D.
- North D. C.
- Parsons T.
- Peck J.
- Peck J.
- Polanyi I. D.
- Polanyi K.
- Polanyi K.
- Polanyi K.
- Polanyi K.
- Polanyi K.
- Polanyi K.
- Polanyi-Levitt K.
- Polanyi-Levitt K.
- Polanyi-Levitt K.
- Polanyi-Levitt K.
- Polanyi-Levitt K.
- Powell W. W.
- Randies S.
- Randies S.
- Rosner P.
- Sarkany M.
- Sayer A.
- Slater D.
- Smelser J.
- Smelser J.
- Stanfield J. R.
- Stanfield J. R.
- Storper M.
- Storper M.
- Strange S.
- Stubbs R.
- Swedberg R.
- Swedberg R.
- Swedberg R.
- Swedberg R.
- Swedberg R.
- Swedberg R.
- Swedberg R.
- Swedberg R.
- Swedberg R.
- Swedberg R.
- Swedberg R.
- Swedberg R.
- Swedberg R.
- Swedberg R.
- Swedberg R.
- Vezer E.
- Zukin S.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Brain deposition and neurotoxicity of manganese in adult mice exposed via the drinking water
- Author
- A Coban
- A St-Pierre
- A Takeda
- A Uchino
- A Woolf
- AA Kinawy
- AH Rajput
- B Gallez
- B Petit-Demouliere
- BA Pappas
- C Missale
- CA Dodd
- CA Dodd
- Celia A. Dodd
- CW Olanow
- D Hafeman
- D Milatovic
- D Santos
- DC Dorman
- DC Dorman
- DJ Cross
- DP Perl
- DS Avila
- E Bonilla
- EJ Talavera
- F Salehi
- F Zhao
- FM Cordova
- FS Messiha
- G Miller
- G Royl
- GA Wasserman
- GP Lim
- GS Shukla
- H Ageta
- H Chaki
- H Eriksson
- H Shinotoh
- H Takeuchi
- I Lazrishvili
- J Kim
- JA Moreno
- JA Moreno
- JC Lai
- JD Park
- JF Staropoli
- JG Anderson
- JH Lee
- JM Antonini
- JM Malheiros
- JS Schneider
- K Blecharz-Klin
- K Ljung
- KA Josephs
- KM Erikson
- KM Erikson
- L Prut
- M Aschner
- M Aschner
- M Aschner
- M Bouchard
- M Hogas
- M Liu
- M Parenti
- M Sedelis
- M Selikhova
- M Tomas-Camardiel
- M Torrente
- M Umezawa
- MF Bouchard
- MF Struve
- MG Cersosimo
- MN Subhash
- MT Perona
- NA Bock
- NC Burton
- Nikolay M. Filipov
- NM Filipov
- NM Filipov
- O Eschenko
- P Bagga
- P Calabresi
- P McLaughlin
- P Vieregge
- P Zhang
- PJ Kontur
- PK Pal
- R Witholt
- RG Lucchini
- RH Belmaker
- RJ Wurtman
- RM Bowler
- RM Bowler
- S Fordahl
- S Sen
- S Zhang
- Saritha Krishna
- Shahryar K. Hekmatyar
- SV Chandra
- SV Chandra
- T Deak
- T Verina
- T Vezer
- TD Sotnikova
- TR Guilarte
- TR Guilarte
- TR Guilarte
- TT Tran
- V Mosienko
- VA Fitsanakis
- VA Fitsanakis
- W Laohaudomchok
- X Liu
- XG Kondakis
- Y Finkelstein
- Y Hirata
- Y Jiao
- YT Kuo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Das adrenocorticotrope Hormon (ACTH), die HormonederNebenniere(Cortison,Adrenalin) das Insulin, sowie die Hormone der SchilddrĂĽse und NebenschilddrĂĽse
- Author
- - Hydrocortison
- A Agostini
- A Ana
- A Ban
- A Bodansky
- A Bottoli
- A Boutelier
- A Buchholz
- A Buschke
- A Buschke
- A Buschke
- A Crosbie
- A Devoto
- A Dorfmann
- A Fleckenstein
- A Francechetti
- A Holste
- A Hottinger
- A Hutsebaut
- A Jackson
- A Kohn
- A Kristjansen
- A Labhart
- A Labhart
- A Leinbrock
- A Lichtwitz
- A Lichtwitz
- A Linke
- A Linke
- A Lorenzo
- A Mclean
- A NilzÉN
- A Pautrier
- A Pelzig
- A Perdrup
- A Philipp
- A Proppe
- A Prout
- A Rubin
- A Salomon
- A Scott
- A Simeray
- A Souza
- A Steppert
- A StĂ–Rmer
- A Tzanck
- A Ullmo
- A Vajda
- A White
- A Wiskemann
- AA Fisher
- AB Cannon
- AB French
- AB Hastings
- AC Curtis
- AC Woods
- AD Forrest
- Adrenalin und Noradrenalin
- AE Renold
- AE Renold
- AF Polley
- AG Fergusson
- AH Bleier
- AH Conrad
- AJ Bollet
- AJ Bret
- AJ Edelstein
- AJ Edelstein
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- AL Welsh
- ALVAREZ-LOWELL y SOTO-MELO
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- AN Tulip
- ANSELMINO K. J., F. HOFFMANN U. L. HEROLD
- APR James
- AR Feinberg
- AS Cohen
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- Corticoid rebound-phenomenon in the rat. Vortr. III. Acta Endoer. Congr. Leiden 16.19. 6. 1958. Abschwächung der sekundären NNR-Atrophie durch discontinuierliche Corticoidgaben. Vortr. 6. Symp. Dtsch. Ges. Endokr.,Kiel
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- JW Didcoct
- JW Hallett
- JW Kemper
- JWS Harris
- K Bojanowicz
- K Fukuyama
- K Halter
- K Halter
- K Halter
- K Hofmann
- K Kirkeby
- K KĂ„Rcher
- K Laros
- K Laros
- K Sigg
- K Sugiura
- K Vohwinkel
- K Vohwinkel
- K Voit
- K Wiemers
- K Wiemers
- KA Rasmussen
- KAJ JĂ„Rvinen
- KE SchrÄDer
- KH Burdick
- KH KĂ„Rcher
- KLEINE-NATROP H. E.
- Klinische Studien mit 9-Alpha-Fluorhydrocortison
- KM West
- KW Kalkoff
- KW Kalkoff
- KĂ–PF
- L Ballestero
- L Ballestero
- L Binder
- L Facia
- L Feher
- L Forman
- L Frank
- L Frank
- L Garcia
- L Goldman
- L Goldman
- L Goldman
- L Goldman
- L Goldman
- L Goldman
- L Goldman
- L Goldman
- L Heilmeyer
- L Heilmeyer
- L Hollander
- L Illig
- L Illig
- L Joulia
- L Koslowski
- L Lammers
- L Lammers
- L Leger
- L Leger
- L Pfleger
- L Pfleger
- L Reznick
- L Riccardi
- L Semmola
- L Thomas
- L Thomas
- L Thomas
- L Tulipan
- L Vissian
- L WeingÄRtner
- L Weissbecker
- L Zachariae
- L Ziprkowski
- L. HOLLANDER
- LA Berman
- LA Janoff
- LAGUESSE
- LATOTZKI
- LATOTZKI
- LC Goldberg
- LD PodestÀ
- LE Coulant
- LE Hollister
- Le renfort de corticostéroïdes dans le traitement des maladies infectieuses
- LE Savitt
- LE Siltzbach
- LEINBROCK
- LEINBROCK
- Les nouveaux corticostéroides syn-thétiques
- LG Jekel
- LG Rowntree
- LH Criep
- LH Sarett
- Lipodystrophy following insulin injections
- LJ Soffer
- LJ Soffer
- LJ Soffer
- LM Pautier
- Lokalbehandlung von Hautkrankheiten mit Hydrocortison
- LOT Gtjil
- LP Barker
- LS Goodman
- LS Goodman
- LS Goodman
- LS Goodman
- LW Kinsell
- M Agosin
- M AllgĂ–Wer
- M Bernheim
- M Bolgert
- M Bolgert
- M Bolgert
- M Bolgert
- M Bolgert
- M Bolgert
- M Crisalli
- M Depaoli
- M Derot
- M Golay
- M Goldston
- M Gordon
- M Iversen
- M Janbon
- M Jeune
- M Joseph
- M JĂ„Nner
- M Lebsanft
- M Lebsanft
- M Lincoln
- M Lincoln
- M Morin
- M Morris
- M Morris
- M MĂśLler
- M Nonclercq
- M NĂśCkel
- M Reiner
- M Roche
- M Scherler
- M Schoog
- M Schubert
- M Schwartz
- M Simonsen
- M Spengler
- M Stefanini
- M Steiger
- M Vogt
- M Wolf
- M Zadunaisky
- M Zeller
- M-P Tuchmann-Duplessis
- M-P Tuchmann-Duplessis
- MA Rothschild
- MA Sayers
- MATTER .W
- MB Sulzberger
- MB Sulzberger
- MB Sulzberger
- MB Sulzberger
- MB Sulzberger
- MB Sulzberger
- MB Sulzberger
- MB Sulzberger
- MB Sulzberger
- MB Sulzberger
- MB Sulzberger
- MB Sulzberger
- MC Li
- MC Li
- MELZER
- Meticorten (prednison) and meticortelone (Prednisolon) in the treatment of allergic disorders
- MEYER-BERKE
- MEYER-ROHN J., u. B. ROHDE
- MF Allende
- MF Oliver
- MG Philpott
- MH Moscona
- MH Samitz
- MI Quiroga
- MIERZECKI
- MJ Brunner
- MJ Costello
- MJ Costello
- MJ Costello
- MJ Small
- MJ Steinhardt
- MJ Woerdemann
- ML Niedelman
- MM Cahn
- MM Robinson
- MOGIL’NICKAJA B. Z.
- MONTGOMERY
- MOORE
- MS Falk
- MUSSLER
- MV Clarmann
- N Ashton
- N Gligorova
- N Gligorova
- N Kendall
- N Sobel
- NB Kanof
- NB Kanof
- NC Birkhead
- NEIMANN
- NL Wendler
- NM Wrong
- O BRAUN-FALCO
- O Burian
- O Dietz
- O Gans
- O Hornstein
- O Preisler
- O Refvem
- O Scott
- O Singer
- O Volterani
- O Wintersteiner
- OBERSTE-LEHNE H
- OEHME
- O’LEARY P. A., H. MONTGOMERY, A. BRUNSTING and R. R. KIERLAND
- P Alphonse
- P Bernasconi
- P Breton
- P Caccialanza
- P Cerutti
- P Chana
- P Crassweller
- P Eichholz
- P FĂ–Ldvari
- P Girard
- P Hall-Smith
- P Hee
- P Kroepfli
- P Lafgier
- P Lafgier
- P Latjgier
- P Latjgier
- P Lechelle
- P Lechelle
- P Leger
- P Leger
- P Meyer
- P Munson
- P Nazzaro
- P Preziosi
- P Schtjp
- P Stricker
- P Vernier
- P Wallentin
- P Zierz
- PA Morales
- PASCHER F., and S. C. CLYMAN
- PB Mumford
- PDE Fremery
- PDE Graciansky
- PDE Graciansky
- PDE Graciansky
- PDE Graciansky
- PDE Graciansky
- PDE Graciansky
- PDE Graziansky
- PDE Nicola
- PE Bechet
- PE Smith
- PEARSON 0. H., L. P. ELIEL, R. W. RAWSON, K. DOBRINER and C. P. RHOADS
- Pemphigoid treated with corticosteroids
- PERERA G. A., C. RAG AN and S. C.WERNER
- PH Forsham
- PH Forsham
- PH Forsham
- PH Hennemann
- PH Rossier
- PH Schaper
- PHS Hench
- PJ Hare
- PJ Michel
- PJ Michel
- PJ Michel
- PJ Michel
- PRIBILLA
- PS Hench
- PS Hench
- PW Schmidt
- R Abderhalden
- R Alexander
- R Debre
- R Degos
- R Degos
- R Degos
- R Degos
- R Degos
- R Degos
- R Degos
- R Degos
- R Doepfmer
- R Fleming
- R Gaunt
- R Goldman
- R Grant
- R Gross
- R Haynes
- R Hoigne
- R Huy-Berechts
- R Hy
- R Kaden
- R Koff
- R Koou
- R Lenggenhager
- R Lenggenhager
- R Mccor
- R Meara
- R Nebotjt
- R Prosiegel
- R Prosiegel
- R Quintin
- R Santler
- R Scerrato
- R SchaerstrĂ–M
- R Schuppli
- R Schuppli
- R Schwyzer
- R StÄPs
- R Turell
- R Wolter
- R Zintz
- RA Carey
- RA Cleghorn
- RA Cooke
- RAASCHOU-NIELSEN W., U. F. REYMANN
- RB Scott
- RB Stoughton
- RB Welbourn
- RB Woodward
- RC Crafts
- RC Moehlig
- RCV Robinson
- RD Sullivan
- RE Billingham
- RE Church
- RE Peterson
- RE Rich
- REYMANN F., and P. SOBYE
- RF Clark
- RF Escamillo
- RG Mitchel
- RG Paley
- RH Harris
- RH Johnson
- RH Orr
- RH Preston
- RH Preston
- RH Wehnert
- RICHTER
- RISSE-STTNDERMANN A.
- RJ Haggerty
- RJ Hoagland
- RJS Bayliss
- RL Dobson
- RL Satjvan
- RL Sutton
- RL Sutton
- RL Sutton
- RL Zwemer
- RM Schick
- Roux
- RR Forsey
- RR Kierland
- RS Evans
- RW Keeton
- S Battaglini
- S Baume
- S Bernstein
- S Bluefarb
- S Borelli
- S Feinberg
- S Goldblatt
- S Hestetum
- S Jablonska
- S Jablonska
- S Lapiere
- S Lapiere
- S Moeschlin
- S Moeschlin
- S Neumark
- S Olansky
- S Pariser
- S Pautrier
- S Ricciardi
- S Sampaio
- S Scwebel
- S. W. CosGRiFF
- SA Walker
- SC Bukantz
- SC Bukantz
- SC Dees
- SCHRĂ–PL
- SG Cohen
- SG Taylor
- SG Taylor
- SH Sandifer
- SH Swift
- SH Swift
- SHERWIN-WEIDENREICH K., F. HERRMANN U. M. B. SULZBERGER
- SHUMAN
- SJ Bosch
- SJ Dencker
- SJ Wilson
- SM Feinberg
- SM Feinberg
- SM Feinberg
- SS Fajans
- SS Siegel
- ST Flamm
- ST FĂ„Rber
- ST Rothman
- ST Rothman
- ST Wyss
- STEPHAN
- Struktur und Funktion neuro-sekretorischer Systeme
- STĂ–REN
- SW Cosgriff
- T Addison
- T Aguas De
- T Bielicky
- T Gillman
- T Hirose
- T Jotjlia
- T Jotjlia
- T Jotjlia
- T Joulia
- T Mandelbaum
- T Reichstein
- TAKEI
- TAUBER
- TB Fitzpatrick
- TD Spies
- TE Anderson
- TF Dougherty
- TF Dougherty
- TF Dougherty
- TG Johnston
- TG Randolph
- TH Alajouanine
- TH Cornbleet
- TH Cornbleet
- TH Cornbleet
- TH GRĂśNEBERG
- TH GrĂśNeberg
- TH GrĂśNeberg
- TH GrĂśNeberg
- TH Ingalls
- TH Matner
- TH Mcgavack
- TH Schreus
- THE Nix
- THELIN F.,N
- THH Sternberg
- THI Florence
- Topical applications of more soluble forms of hydrocortisone. A comparison with hydrocortisone acetate and hydrocortisone (free alcohol)
- TUCHMANN-DUPLESSIS
- TW Oppel
- U Diamant
- U Grahlow
- U Wetzel
- UK Engelhart
- URS Arellano
- USV Euler
- V Fontan
- V KĂ–Hler
- V Schmidt
- V Smejkal
- V Vezer
- VC Raimondo
- VH Witten
- VH Witten
- VH Witten
- VO Dollmann
- VS Wammock
- W Bargmann
- W BeiglbĂ–Ck
- W BrĂśHl
- W Burckhardt
- W Damashek
- W Dirscherl
- W Dirscherl
- W Dontenwill
- W DĂ–Lle
- W DĂ–Ssekker
- W GeisthĂ–Vel
- W Gertler
- W Graumann
- W Hijmans
- W Hohlweg
- W Jadassohn
- W Jadassohn
- W Keller
- W Kiessling
- W Korus
- W Ktjzell
- W KĂśHnau
- W KĂśHnau
- W MeyhĂ–Fer
- W Pepler
- W Plenert
- W Pribilla
- W Schmitt
- W Schneider
- W Schulze
- W Siegenthaler
- W Tilling
- W Tilling
- W Wittels
- W Zimmermann
- WA Niermann
- WA Pusey
- WB Shelley
- WB Shelley
- WC Grater
- WC Stadie
- WEISSENBACH
- Weitere Untersuchungen ĂĽber die Beeinflussung der Wirkung lokal angewendeter Nebennierenrindenhormone. Vortr. XXXV. Tagg Dtsch. Derm. Ges. Hamburg 19.22. 5
- WF Lever
- WF Lever
- WG Maccalltjm
- WG Simpson
- WH Oatway
- WH Sheldon
- WJ Finegold
- WM Tate
- WM Tate
- WO Reinhardt
- WOLFRAM
- WQ Wolfson
- WQ Wolfson
- WQ Wolfson
- WR Nickel
- WS Eisenstadt
- WULF
- WW Spink
- WW Swingle
- WW Swingle
- WW Swingle
- WW Swingle
- X Vilanova
- Y Bureau
- Y Bureau
- Y Bureau
- Z Kraus
- Zbl. Ref
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1961
- Field of study