Aromatherapy: The Power of Scent

An alternative (in medicine) is a substance that speeds up the renewal of the tissues so that they can carry out their functions more efficiently. Aromatherapy is one such method of healing, using volatile oils. This article was prepared to give the reader more information on the usage of essential oils

Studies on Some Pharmacognostic Profiles of \u3cem\u3eBauhinia purpurea\u3c/em\u3e Linn. Leaves (Caesalpinaceae)

The leaves of Bauhinia purpurea Linn. were studied with the aim of determining the following pharmacognostical parameters for this species: Macroscopical characters; Leaf constants; Physico-chemical constants; Extractive values; Colour; Consistency; Extractive values with different solvents; Micro chemical tests; Fluorescence characters of liquid extracts and leaf powder after treatment with different chemical reagents under visible and UV light at 254 nm & 366 nm; Measurement of cells and tissues; Bulk density angle of repose; and, Powder microscopy. Hopefully, the determination of these characteristics will aid future investigators in their pharmacological analyses of this species. Preliminary pytochemical studies on different extracts of the leaves were also performed

Locomotor Activity of Leaf Extracts of \u3cem\u3ePithecellobium dulce\u3c/em\u3e Benth.

Objective: To study Locomotor activity of aqueous and alcoholic extracts of leaves of Pithecellobium dulce Benth. Materials and methods: CNS depressant activity of leaf extracts of P. dulce was evaluated using actophotometer in albino mice. The potency of alcoholic and aqueous extracts of leaf was compared with that of chlorpromazine at a dose of 100 mg/kg. The acute toxicity was determined using albino mice. Results: Both extracts caused significant CNS depression action in albino mice. The activity of alcoholic extract was more, when compared to chlorpromazine. Conclusion: CNS depression action of extracts may be due to increase in the concentration of GABA in brain

Free Radical Scavenging Activity of Folklore: \u3cem\u3ePithecellobium dulce\u3c/em\u3e Benth. Leaves

In the present study, the aqueous and alcoholic extract of Pithecellobium dulce leaves were evaluated for radical scavenging activity using reducing power assay method. Aqueous extract showed potent free radical scavenging activity, than alcohol extract. The observed activity could be due to higher phenolic content in the extracts (0.2171& 0.2042 mg/g in aqueous and alcohol extract respectively). HPTLC fingerprint profile of the ethanol and aqueous extracts were developed which would serve as reference standard for quality control of these extract

Spectrophotometric method for estimation of desvenlafaxine succinate in tablet dosage form

ABSTRACT Two simple and sensitive spectrophotometric methods (A and B) for the determination of desvenlafaxine succinate in tablet dosage form are described. In the method A -Simple UV Spectrophotometric method, distilled water was used as solvent and shows absorption maxima at 224.5 nm. In the method B -Difference Spectrophotometric method, the proposed method is based on the principle that desvenlafaxine succinate can exhibit two different chemical form in basic and acidic medium that differ in the absorption spectra in basic and acidic medium. The difference spectrum of desvenlafaxine succinate in 0.01 M Sodium hydroxide was recorded by taking desvenlafaxine succinate in 0.1 M Hydrochloric acid solution as blank. The difference spectrum showed that the maxima at 240 nm and minima at 224.5 nm. The Beer's law range for method A is 5 -40 µg/mL and 8 -40 µg/mL for method B. The linear regression for method A and B are found to be 0.99992 and 0.99994 respectively. When tablet dosage form where analyzed, the results are obtained by the proposed methods are in good agreement with the labeled amount and the results were validated statistically

Simultano UV-spektrofotometrijsko određivanje ramiprila, acetilsalicilne kiseline i atorvastatin kalcija u kapsulama primjenom kemometrijskih metoda

In the present work, three different spectrophotometric methods for simultaneous estimation of ramipril, aspirin and atorvastatin calcium in raw materials and in formulations are described. Overlapped data was quantitatively resolved by using chemometric methods, viz. inverse least squares (ILS), principal component regression (PCR) and partial least squares (PLS). Calibrations were constructed using the absorption data matrix corresponding to the concentration data matrix. The linearity range was found to be 1-5, 10-50 and 2-10 µg mL–1 for ramipril, aspirin and atorvastatin calcium, respectively. The absorbance matrix was obtained by measuring the zero-order absorbance in the wavelength range between 210 and 320 nm. A training set design of the concentration data corresponding to the ramipril, aspirin and atorvastatin calcium mixtures was organized statistically to maximize the information content from the spectra and to minimize the error of multivariate calibrations. By applying the respective algorithms for PLS 1, PCR and ILS to the measured spectra of the calibration set, a suitable model was obtained. This model was selected on the basis of RMSECV and RMSEP values. The same was applied to the prediction set and capsule formulation. Mean recoveries of the commercial formulation set together with other figures of merit (calibration sensitivity, selectivity, limit of detection, limit of quantification and analytical sensitivity) were estimated. Validity of the proposed approaches was successfully assessed for analyses of drugs in the various prepared physical mixtures and formulations.U radu su opisane tri različite spektrofotometrijske metode za određivanje ramiprila, acetilsalicilne kiseline i atorvastatin kalcija u sirovinama i formulacijama. Preklapanje podataka kvantitativno je riješeno pomoću kemometrijskih metoda, tj. metodama inverznih najmanjih kvadrata (ILS), regresije glavnog sastojka (PCR) i djelomičnih najmanjih kvadrata (PLS). Kalibracije su postavljene pomoću matrice podataka za apsorpciju koja odgovara matrici pripadajućih koncentracija. Područje linearnosti za ramipril iznosilo je 1–5, za acetilsalicilnu kiselinu 10–50, a za atorvastatin kalcij 2–10 µg mL–1. Matrica s apsorbancijama dobivena je mjerenjem apsorbancije nultog reda na valnim duljinama između 210 i 320 nm. Set podataka za koncentracije ramiprila, acetilsalicilne kiseline i atorvastatin kalcija u smjesi statistički je tako organiziran da osigura maksimalnu količinu informacije u spektrima i minimalizira grešku multivarijantnih kalibracija. Primjenom odgovarajućih algoritama za PLS, PCR i ILS na snimljene spektre kalibracijskog seta dobiven je dobar model, koji je odabran na temelju RMSECV i RMSEP vrijednosti. Isti model je primijenjen i na set s predviđenim vrijednostima i na kapsule sa smjesom ove tri ljekovite tvari. Određena je srednja vrijednost povrata za komercijalnu formulaciju te ostale analitičke izvedbene značajke (kalibracijska osjetljivost, selektivnost, granica dokazivanja, granica određivanja i analitička osjetljivost). Potvrđena je primjenjljivost predloženih metoda u analizama lijekova u fizičkim smjesama i u gotovim ljekovitim oblicima