9 research outputs found
Enantioselective Dynamic Process Reduction of α- and β-Tetralone and Stereoinversion of Resulting Alcohols in a Selected Strain Culture
α-Tetralone and β-tetralone were subjected to biotransformation by 14 fungal strains. Enantiomeric purity of the products depended on the reaction time. 3-Day transformation of α-tetralone in Absidia cylindrospora culture gave S-(+)-1,2,3,4-tetrahydro-1-naftol of 92 % ee, whereas longer biotransformation time resulted in decrease of ee value. 3-Day transformation of β-tetralone by the same strain gave predominantly S-(−)-1,2,3,4-tetrahydro-2-naftol, whereas after 9 days of the reaction, the R-enantiomer with 85 % ee was isolated. Transformation of β-tetralone by Chaetomium sp. KCh 6651 gave pure (S)-(−)-1,2,3,4-tetrahydro-2-naftol in high yield at the concentration of 1 g/l. In this process, a non-selective carbonyl reduction was observed, followed by a selective oxidation of the R-alcohol
Asymmetric hydrosilylation of ketones catalyzed by complexes formed from trans-diaminocyclohexane-based diamines and diethylzinc
The reaction of α-halocarbonyl compounds with (NH<sub>4</sub>)OH, (NH<sub>4</sub>)<sub>2</sub>SO<sub>4</sub> or NH<sub>4</sub>Cl solution under microwave-irradiation
1495-1502Reaction of α-halo ketone (α-bromo ketone) under microwave irradiation gives the pyrazine and quinoxaline derivative in good yields. This reaction affords a clean and convenient synthetic method for pyrazine and quinoxaline derivatives