292 research outputs found
Principal Component Analysis of Cavity Beam Position Monitor Signals
Model-independent analysis (MIA) methods are generally useful for analysing
complex systems in which relationships between the observables are non-trivial
and noise is present. Principle Component Analysis (PCA) is one of MIA methods
allowing to isolate components in the input data graded to their contribution
to the variability of the data. In this publication we show how the PCA can be
applied to digitised signals obtained from a cavity beam position monitor
(CBPM) system on the example of a 3-cavity test system installed at the
Accelerator Test Facility 2 (ATF2) at KEK in Japan. We demonstrate that the PCA
based method can be used to extract beam position information, and matches
conventional techniques in terms of performance, while requiring considerably
less settings and data for calibration
Effect of Compton Scattering on the Electron Beam Dynamics at the ATF Damping Ring
Compton scattering provides one of the most promising scheme to obtain
polarized positrons for the next generation of -- colliders.
Moreover it is an attractive method to produce monochromatic high energy
polarized gammas for nuclear applications and X-rays for compact light sources.
In this framework a four-mirror Fabry-P\'erot cavity has been installed at the
Accelerator Test Facility (ATF - KEK, Tsukuba, Japan) and is used to produce an
intense flux of polarized gamma rays by Compton scattering
\cite{ipac-mightylaser}. For electrons at the ATF energy (1.28 GeV) Compton
scattering may result in a shorter lifetime due to the limited bucket
acceptance. We have implemented the effect of Compton scattering on a 2D
tracking code with a Monte-Carlo method. This code has been used to study the
longitudinal dynamics of the electron beam at the ATF damping ring, in
particular the evolution of the energy spread and the bunch length under
Compton scattering. The results obtained are presented and discussed. Possible
methods to observe the effect of Compton scattering on the ATF beam are
proposed
Development of Diamond Sensors for Beam Halo and Compton Spectrum Diagnostics after the Interaction Point of ATF2
MOPME003 - Work supported by the CSC (File NO.201206170138). ISBN 978-3-95450-122-9International audienceATF2 is a low energy (1.3GeV) prototype of the final focus system for ILC and CLIC linear collider projects. A major issue at ATF2 and in linear colliders is to control the beam halo, which consists of tails extending far beyond the Gaussian core of the beam. At present there is no dedicated collimation for the beam halo at ATF2, and the transverse distribution near the interaction point is not well known. The development of a sensor based on CVD diamond to scan the beam halo in the vacuum chamber a few meters after the interaction point is presented. This system also aims to detect the Compton recoil electrons generated by the laser interferometer (Shintake monitor) used to measure the beam size at the interaction point of ATF2
GABA(A) receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein
GABA(A) receptors are critical in controlling neuronal activity. Here, we examined the role for phospholipase C-related inactive protein type 1 (PRIP-1), which binds and inactivates protein phosphatase 1alpha (PP1alpha) in facilitating GABA(A) receptor phospho-dependent regulation using PRIP-1(-/-) mice. In wild-type animals, robust phosphorylation and functional modulation of GABA(A) receptors containing beta3 subunits by cAMP-dependent protein kinase was evident, which was diminished in PRIP-1(-/-) mice. PRIP-1(-/-) mice exhibited enhanced PP1alpha activity compared with controls. Furthermore, PRIP-1 was able to interact directly with GABA(A) receptor beta subunits, and moreover, these proteins were found to be PP1alpha substrates. Finally, phosphorylation of PRIP-1 on threonine 94 facilitated the dissociation of PP1alpha-PRIP-1 complexes, providing a local mechanism for the activation of PP1alpha. Together, these results suggest an essential role for PRIP-1 in controlling GABA(A) receptor activity via regulating subunit phosphorylation and thereby the efficacy of neuronal inhibition mediated by these receptors
Laserwire at the Accelerator Test Facility 2 with Sub-Micrometre Resolution
A laserwire transverse electron beam size measurement system has been
developed and operated at the Accelerator Test Facility 2 (ATF2) at KEK.
Special electron beam optics were developed to create an approximately 1 x 100
{\mu}m (vertical x horizontal) electron beam at the laserwire location, which
was profiled using a 150 mJ, 71 ps laser pulse with a wavelength of 532 nm. The
precise characterisation of the laser propagation allows the non-Gaussian
transverse profiles of the electron beam caused by the laser divergence to be
deconvolved. A minimum vertical electron beam size of 1.07 0.06 (stat.)
0.05 (sys.) {\mu}m was measured. A vertically focussing quadrupole just
before the laserwire was varied whilst making laserwire measurements and the
projected vertical emittance was measured to be 82.56 3.04 pm rad.Comment: 17 pages, 26 figures, submitted to Phys. Rev. ST Accel. Beam
IL-12 Production Induced by Agaricus blazei Fraction H (ABH) Involves Toll-like Receptor (TLR)
Agaricus blazei Murill is an edible fungus used in traditional medicine, which has various well-documented medicinal properties. In the present study, we investigated the effects of hemicellulase-derived mycelia extract (Agaricus blazei fraction H: ABH) on the immune system. First, we examined the cytokine-inducing activity of ABH on human peripheral mononuclear cells (PBMC). The results indicated that ABH induced expression of IL-12, a cytokine known to be a critical regulator of cellular immune responses. Flow cytometric analysis demonstrated the induction of IL-12 production by the CD14-positive cell population, consisting of monocytes/macrophages (Mo/Mφ). Furthermore, the elimination of Mo/Mφ attenuated IL-12 production in PBMC. ABH-induced IL-12 production was inhibited by anti-CD14 and anti-TLR4 antibodies but not by anti-TLR2 antibody. The activity of ABH was not inhibited by polymyxin B, while the activity of lipopolysaccharide used as a reference was inhibited. Oral administration of ABH enhanced natural killer (NK) activity in the spleen. These findings suggest that ABH activated Mo/Mφ in a manner dependent on CD14/TLR4 and NK activity
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