1,867 research outputs found
Incommensurate-Commensurate Magnetic Phase Transition in SmRuAl
Magnetic properties of single crystalline SmRuAl have been
investigated by electrical resistivity, magnetic susceptibility, and specific
heat. We have confirmed the successive magnetic phase transitions at
K and K. Resonant x-ray diffraction has
also been performed to study the magnetic structures. Below , the
Sm moments order in an incommensurate structure with . The magnetic moments are oriented along the orthorhombic axis, which
coincides with the magnetization easy axis in the paramagnetic phase. A very
weak third harmonic peak is also observed at . The
transition at is a lock-in transition to the commensurate
structure described by . A well developed third harmonic peak
is observed at . From the discussion of the magnetic
structure, we propose that the long-range RKKY interaction plays an important
role, in addition to the strong nearest neighbor antiferromagnetic interaction.Comment: 11 pages, 12 figures, accepted in PR
Stable Existence of Phase IV inside Phase II under Pressure in CeLaB
We investigate the pressure effect of the electrical resistivity and
magnetization of CeLaB. The situation in which phase IV
stably exists inside phase II at H=0 T could be realized by applying a pressure
above GPa. This originates from the fact that the stability of
phase II under pressure is larger than those of phases IV and III. The results
seem to be difficult to reproduce by taking the four interactions of
-type AFO, -type AFQ, -type AFO, and AF
exchange into account within a mean-field calculation framework.Comment: 4 pages, 5 figures, to appear in J. Phys. Soc. Jpn. 79 (2010) No.
Kondo effect in CeX (X=S, Se, Te) studied by electrical resistivity under high pressure
We have measured the electrical resistivity of cerium monochalcogenices, CeS,
CeSe, and CeTe, under high pressures up to 8 GPa. Pressure dependences of the
antiferromagnetic ordering temperature , crystal field splitting, and
the anomaly of the Kondo effect have been studied to cover the whole
region from the magnetic ordering regime at low pressure to the Fermi liquid
regime at high pressure. initially increases with increasing pressure,
and starts to decrease at high pressure as expected from the Doniach's diagram.
Simultaneously, the behavior in the resistivity is enhanced, indicating
the enhancement of the Kondo effect by pressure. It is also characteristic in
CeX that the crystal field splitting rapidly decreases at a common rate
of K/GPa. This leads to the increase in the degeneracy of the state
and further enhancement of the Kondo effect. It is shown that the pressure
dependent degeneracy of the state is a key factor to understand the
pressure dependence of , Kondo effect, magnetoresistance, and the peak
structure in the temperature dependence of resistivity.Comment: 9 pages, 5 figures, accepted for publication in J. Phys. Soc. Jp
X-Ray Diffraction Study of CeT2Al10 (T = Ru, Os) at Low Temperatures and under Pressures
We have carried out a powder X-ray diffraction investigation on antiferromagnetic Kondo semiconductorsCeRu2Al10 and CeOs2Al10 at low temperatures and under high pressures as well as the structural investigationon single crystal of these compounds. The results of powder X-ray studies of CeRu2Al10 and CeOs2Al10 indicatethat these compounds do not have structural transition at its antiferromagnetic ordering temperature. The resultsof single crystal structural refinement indicate that the b-axis of this crystal structure is insensitive not only topressure but also to temperature and that the effect of cooling to Ce–Ce distance for CeRu2Al10 is the same asthat for CeOs2Al10
Adenoviral p53 gene therapy for lung cancer
To determine the feasibility, safety, humoral immune response, and biological activity of multiple intratumoral injections of Ad5CMV-p53, and to characterize the pharmacokinetics of Ad5CMV-p53 in patients with advanced non-small cell lung cancer (NSCLC). Fifteen patients with histologically confirmed NSCLC and p53 mutations were enrolled into this phase I trial. Nine patients received escalating dose levels of Ad5CMV-p53 (1 × 109 to 1 × 1011 plaque-forming units[PFU]) as monotherapy once every 4 weeks. Six patients were treated on a 28-day schedule with Ad5CMV-p53 in combination with intravenous administration of cisplatin (80 mg/m2). Patients were monitored for toxicity, vector distribution, antibody formation, and tumor response. Fifteen patients received a total of 63 intratumoral injections of Ad5CMV-p53 without dose-limiting toxicity. The most common treatment-related toxicity was a transient fever. Specific p53 transgene expression was detected using reverse-transcriptase polymerase chain reaction in biopsied tumor tissues throughout the period of treatment despite of the presence of neutralizing anti-adenovirus antibody. Distribution studies revealed that the vector was detected in the gargle and plasma, but rarely in the urine. Thirteen of 15 patients were assessable for efficacy; one patient had a partial response (squamous cell carcinoma at the carina), 10 patients had stable disease, with three lasting ≥9 months, and 2 patients had progressive disease. Multiple courses of intratumoral Ad5CMV-p53 injection alone or in combination with intravenous administration of cisplatin were feasible and well tolerated in advanced NSCLC patients, and appeared to provide clinical benefit
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