45 research outputs found
ePS3.03 Ventilatory parameters during cardiopulmonary exercise testing (CPET) in people with Cystic Fibrosis-Related Diabetes (CFRD): a potential barrier to exercise?
Ventilatory response to exercise in adolescents with cystic fibrosis and mild-to-moderate airway obstruction
Resistance through realism : Youth subculture films in 1970s (and 1980s) Britain
This document is the Accepted Manuscript version of the following article: Nathaniel Weiner, âResistance through realism: Youth subculture films in 1970s (and 1980s) Britainâ. The final, definitive version of this paper has been published in European Journal of Cultural Studies, November 2015, DOI: https://doi.org/10.1177/1367549415603376. Published by SAGE Publishing.Film scholars have argued that the British social realist films of the late 1950s and early 1960s reflect the concerns articulated by British cultural studies during the same period. This article looks at how the social realist films of the 1970s and early 1980s similarly reflect the concerns of British cultural studies scholarship produced by the University of Birminghamâs Centre for Contemporary Cultural Studies during the 1970s. It argues that the Centre for Contemporary Cultural Studiesâ approach to stylised working-class youth subcultures is echoed in the portrayal of youth subcultures in the social realist films Pressure (1976), Bloody Kids (1979), Babylon (1980) and Made in Britain (1982). This article explores the ways in which these films show us both the strengths and weaknesses of the Centre for Contemporary Cultural Studiesâ work on subcultures.Peer reviewe
long-term effect of dietary supplementation with fish lipid concentrate on serum lipids, bleeding time, platelets and angina. Atherosclerosis
Summary The effect of a fish lipid concentrate rich in eicosapentaenoic acid was studied in 107 subjects for periods up to 2 years. Ninety-two had heart disease or hyperlipidaemia and 15 had no history of heart disease. Serum triglyceride levels were rapidly reduced, cholesterol fell more slowly but high density lipoprotein (HDL) cholesterol was increased. Bleeding time increased significantly and the consumption of glyceryl trinitrate (GTN) tablets decreased together with a reduction in anginal attacks. The data are consistent with a reduction in hepatic triglyceride synthesis rather than an increased rate of triglyceride clearance. Total and HDL cholesterol changes are suggestive of an enhanced removal of cholesterol from the tissues. Increased bleeding time and changes in GTN consumption are consistent with decreased platelet aggregation
The impact of plasma 25-hydroxyvitamin D on pulmonary function and exercise physiology in cystic fibrosis: a multicentre retrospective study
This is the author accepted manuscript. The final version is available from Wiley via the DOI in this recordBackground
25âhydroxyvitamin D (25OHD) may exert immunomodulatory effects on respiratory health, which may translate to improvements in exercise physiology. Thus, we aimed to investigate whether plasma 25OHD is associated with lung function and aerobic fitness in people with cystic fibrosis (pwCF).
Methods
A multiâcentre retrospective review of pwCF (>9 years old) attending the Royal Hospital for Sick Children (Edinburgh) or Wessex CFâUnit (Southampton) was performed between July 2017 to October 2019. Demographic and clinical data were collected. Plasma 25OHD measured closest in time to clinical cardiopulmonary exercise testing (CPET) and/or spirometry (forced expiratory volume FEV1% predicted) was recorded. Pancreatic insufficiency was diagnosed based on faecal elastase of <100 ”g/g. We performed multipleâregression analysis with aerobic fitness outcomes [peak oxygen uptake (VO2peak)] and FEV1% predicted as primary outcomes.
Results
Ninety pwCF [mean±SD age: 19.1±8.6 years, 54 (60%) children, 48 (53%) males and 88 (98%) Caucasian] were included. 25OHD deficiency and insufficiency was 15 (17%) and 44 (49%) respectively. 25OHD deficiency and insufficiency was significantly associated with pancreatic insufficiency (Ï2(4.8); p = 0.02). Plasma 25OHD was not significantly associated with FEV1% predicted [R2 = 0.06; p= 0.42; 95%; CI (â0.09 â 0.19)] or VO2peak [R2= 0.04; p= 0.07; 95% CI (â011 â 0.005)] in all pwCF. However, 25OHD was significantly associated with both FEV1% [R2= 0.15; p= 0.02; 95% CI (1.99 â 2.64)] and VO2peak [R2= 0.13; p= 0.05; 95% CI (â0.26 â (â0.005)] in the paediatric cohort.
Conclusion
We showed that 25OHD is associated with improved lung function and aerobic fitness in children and adolescents with CF. Mechanistic and highâquality prospective studies including both lung function and aerobic fitness as primary outcomes are now warranted.NHS Lothian Research and Development Offic
Do suspended sediment and bedload move progressively from the summit to the sea along Magela Creek, northern Australia?
Soil erosion rates on plots of waste rock at Ranger uranium mine and basin sediment yields have been measured for over 30 years in Magela Creek in northern Australia. Soil erosion rates on chlorite schist waste rock are higher than for mica schist and weathering is also much faster. Sediment yields are low but are further reduced by sediment trapping effects of flood plains, floodouts, billabongs and extensive wetlands. Suspended sediment yields exceed bedload yields in this deeply weathered, tropical landscape, but the amount of sand transported greatly exceeds that of silt and clay. Nevertheless, sand is totally stored above the topographic base level. Longitudinal continuity of sediment transport is not maintained. As a result, suspended sediment and bedload do not move progressively from the summit to the sea along Magela Creek and lower Magela Creek wetlands trap about 90.5% of the total sediment load input