The Adipose Mast Cell: Mastokines As Binary Modulators Of Disease Processes

A paradigm-shifting discovery of the hormone leptin (in the end of 1994) paved the way toward intensive studies on endocrine and paracrine function of the adipose tissue. Onwards, a wide range of signaling proteins collectively termed adipokines were identified as secretory products of adipose cells including mast cells, a “classical” companion of this tissue. The present review addresses the potential translational relevance of adipose paracrine signaling pertinent to various diseases, particularly atherosclerosis, metabolic syndrome, thyroid-associated (Graves’) ophthalmopathy, and breast and prostate cancer, with special reference to binary (protective versus pathogenic) roles of mastokines, mast cell-derived signaling proteins

TIMED Doppler Interferometer: Overview and recent results

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94617/1/jgra18230.pd

Evidence for stratospheric sudden warming effects on the upper thermosphere derived from satellite orbital decay data during 1967–2013

We investigate possible impact of stratospheric sudden warmings (SSWs) on the thermosphere by using long-term data of the global average thermospheric total mass density derived from satellite orbital drag during 1967–2013. Residuals are analyzed between the data and empirical Global Average Mass Density Model (GAMDM) that takes into account density variability due to solar activity, season, geomagnetic activity, and long-term trend. A superposed epoch analysis of 37 SSW events reveals a density reduction of 3–7% at 250–575 km around the time of maximum polar vortex weakening. The relative density perturbation is found to be greater at higher altitudes. The temperature perturbation is estimated to be −7.0 K at 400 km. We show that the density reduction can arise from enhanced wave forcing from the lower atmosphere

Global distribution and interannual variations of mesospheric and lower thermospheric neutral wind diurnal tide: 1. Migrating tide

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95689/1/jgra18975.pd