901-2 Randomized, Double-Blind Multicenter Trial of a Novel Modified t-PA, E6010 by i.v. Bolus Injection in Treatment of Acute Myocardial Infarction (AMI) – Comparison with Native t-PA

E6010 is a novel modified t-PA, in which cysteine 84 in the epidermal growth factor domain has been replaced by serine. This is the first modified t-PA to be effective by i.v. bolus injection, and it has a prolonged half-life (Tα1/2 > 20 min) compared to native t-PA.A randomized, double-blind multicenter trial of i.v. bolus injection of E601 0, 27,500 EU/kg, compared with native t-PA (cell culture), 14,400,000 IU has been performed in the treatment of AMI of ≤ 6 hr duration and total occlusion of the infarct-related arteries. Angiograms were used to evaluate the patency of infarct-related arteries at 15, 30, 45, and 60 minutes after the administration.Result% Recanalization Rate (TIMI grade 2 or 3)15min.30min.45min60min.E6010n = 9736.561.973.779.4native t-PAn = 10213.732.449.564.7The time to reperfusion with E601 0 was shorter than that with native t-PA. Coronary recanalization at 30 and 60 minutes after administration was obtained in 61.9% and 79.4% of the case with E6010 and in 32.4% and 64.7% of the case with native t-PA, and the difference between both were statistically significant. No fatal bleeding complications were observed in E601 0.4 patients (3.8%) in E6010 and 3 patients (2.8%) in native t-PA died during 48 days post treatment hospitalization.Discussion and ConclusionNative t-PA is required to be administered over period of 1 hr with 10% of the total dose administered as an i.v. bolus and the remainder infused i.v. over 1 hr. Our present results indicate that E601 0 can be easily administered by i.v. bolus injection taking 2–3 minutes and it exerts a valuable thrombolytic effects, namely a high rate and early recanalization of infarct-related arterie

Men under pressure: representations of the `salaryman' and his organization in Japanese manga

In this article we analyse representations of the Japanese salaryman and Japanese organization in Japanese manga, or graphic novels, during the turbulent decades from the mid-1980s to the present day. We argue that manga presents salarymen protagonists in a sympathetic yet not uncritical light, and that it displays support for and criticism of both the Japanese and American organizational models. We describe how these manga offer important critical challenges from the world of popular culture to the direction of change in Japanese business organizations since the 1980s. In addition, we suggest that the manga may also provide salarymen with opportunities for critically re-evaluating their own working situations and for developing methods for surviving and thriving under the pressures of working within contemporary Japanese business organizations