KLF6 and STAT3 Co-Occupy Regulatory DNA and Functionally Synergize to Promote Axon Growth in CNS Neurons

The failure of axon regeneration in the CNS limits recovery from damage and disease. Members of the KLF family of transcription factors can exert both positive and negative effects on axon regeneration, but the underlying mechanisms are unclear. Here we show that forced expression of KLF6 promotes axon regeneration by corticospinal tract neurons in the injured spinal cord. RNA sequencing identified 454 genes whose expression changed upon forced KLF6 expression in vitro, including sub-networks that were highly enriched for functions relevant to axon extension including cytoskeleton remodeling, lipid synthesis, and bioenergetics. In addition, promoter analysis predicted a functional interaction between KLF6 and a second transcription factor, STAT3, and genome-wide footprinting using ATAC-Seq data confirmed frequent co-occupancy. Co-expression of the two factors yielded a synergistic elevation of neurite growth in vitro. These data clarify the transcriptional control of axon growth and point the way toward novel interventions to promote CNS regeneration

Coopetition of software firms in Open source software ecosystems

Software firms participate in an ecosystem as a part of their innovation strategy to extend value creation beyond the firms boundary. Participation in an open and independent environment also implies the competition among firms with similar business models and targeted markets. Hence, firms need to consider potential opportunities and challenges upfront. This study explores how software firms interact with others in OSS ecosystems from a coopetition perspective. We performed a quantitative and qualitative analysis of three OSS projects. Finding shows that software firms emphasize the co-creation of common value and partly react to the potential competitiveness on OSS ecosystems. Six themes about coopetition were identified, including spanning gatekeepers, securing communication, open-core sourcing and filtering shared code. Our work contributes to software engineering research with a rich description of coopetition in OSS ecosystems. Moreover, we also come up with several implications for software firms in pursing a harmony participation in OSS ecosystems.Comment: This is the author's version of the work. Copyright owner's version can be accessed at https://link.springer.com/chapter/10.1007/978-3-319-69191-6_10, Coopetition of software firms in Open source software ecosystems, 8th ICSOB 2017, Essen, Germany (2017

Cytology of conifers. II

Chromosome numbers inPodocarpus falcatus (2n = 24),P. gracilior (n = 12, 2n = 24),P. latifolia (n = 11, 2n = 22) and P. macrophyllus var.Maki (n = 19, 2n = 38) have been recorded. Nothing conclusive can be said as to whether the chromosome number has increased or decreased or both increased and decreased during the course of evolution of the genus

Perfectly Translating Lattices on a Cylinder

We perform molecular dynamics simulations on an interacting electron gas confined to a cylindrical surface and subject to a radial magnetic field and the field of the positive background. In order to study the system at lowest energy states that still carry a current, initial configurations are obtained by a special quenching procedure. We observe the formation of a steady state in which the entire electron-lattice cycles with a common uniform velocity. Certain runs show an intermediate instability leading to lattice rearrangements. A Hall resistance can be defined and depends linearly on the magnetic field with an anomalous coefficient reflecting the manybody contributions peculiar to two dimensions.Comment: 13 pages, 5 figure

Attitudes of Older Adults in a Group-Based Exercise Program Toward a Blended Intervention:A Focus-Group Study

Ageing is associated with a decline in daily functioning and mobility. A physically active life and physical exercise can minimize the decline of daily functioning and improve the physical-, psychological- and social functioning of older adults. Despite several advantages of group-based exercise programs, older adults participating in such interventions often do not meet the frequency, intensity or duration of exercises needed to gain health benefits. An exercise program that combines the advantages of group-based exercises led by an instructor with tailored home-based exercises can increase the effectiveness. Technology can assist in delivering a personalized program. The aim of the study was to determine the susceptibility of older adults currently participating in a nationwide group-based exercise program to such a blended exercise program. Eight focus-groups were held with adults of 55 years of age or older. Two researchers coded independently the remarks of the 30 participants that were included in the analysis according to the three key concepts of the Self Determination Theory: autonomy, competence and relatedness. The results show that maintaining self-reliance and keeping in touch with others were the main motives to participate in the weekly group-based exercises. Participants recognized benefits of doing additional home-based exercises, but had concerns regarding guidance, safety and motivation. Furthermore, some participants strongly rejected the idea to use technology to support them in doing exercises at home, but the majority was open to it. Insights are discussed how these findings can help design novel interventions that can increase the wellbeing of older adults and preserve an independent living.

Reaction of detached fruits of chilli (Capsicum annuum L.) varieties to isolates of Colletotrichum capsici (Syd.) Butler and Bisby

Investigations on the pathogenic potential of nine isolates of Colletotrichum capsici on four chilli (Capsicum annuum) varieties revealed variations in their incubation period and lesion size induced on inoculated fruits. The isolates CC-1, CC-2, CC-3, CC-4, CC-5 and CC-7 gave resistant reaction in all the four varieties. Isolate CC-9 gave susceptible reaction in all the four varieties. Isolate CC-8 induced susceptible reaction in Hisar Shakti and resistant reaction in Hisar Vijay whereas, CC-6 gave susceptible reaction in Hisar Vijay and resistant reaction in Hisar Shakti. &nbsp

Studies in Structure Formation in theories with a repulsive long range gravitational force

This article reports on emergence of structures in a class of alternative theories of gravity. These theories do not have any horizon, flatness, initial cosmological singularity and (possibly) quantization problems. The model is characterised by a dynamically induced gravitational constant with a ``wrong'' sign corresponding to repulsive gravitation on the large scale. A non - minimal coupling of a scalar field in the model can give rise to non - topological solitons in the theory. This results in domains (gravity - balls) inside which an effective, canonical, attractive gravitational constant is induced. We consider simulations of the formation and evolution of such solutions. Starting with a single gravity - ball, we consider its fragmentation into smaller (lower mass) balls - evolving by mutual repulsion. After several runs, we have been able to identify two parameters: the strength of the long range gravitational constant and the size of the gravity balls, which can be used to generate appropriate two point correlations of the distribution of these balls.Comment: Normal Tex, 7 pages, 5 figures available from the author

Mental Health Carve-Outs: Effects and Implications

To control the rise in expenditures and to increase access to mental health and substance abuse (MH/SA) services, a growing number of employers and states are implementing a “carve-out.” Under this arrangement, the sponsor separates insurance benefits by disease or condition, service category, or population and contracts separately for the management of care and/or associated risks. A carve-out allows a unique set of managed care techniques to be applied to a subset of particularly costly or complex benefits. This article describes various carve-out models, discusses the potential advantages and disadvantages of a full carve-out, and summarizes recent public and private sector research regarding the strategy’s effects on access and use, cost savings and shifting, and quality of care. It concludes by discussing approaches to the assessment and monitoring of the processes and outcomes associated with a MH/SA carve-out.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68797/2/10.1177_107755879905600203.pd