12 research outputs found

    Anatomical and Functional Deficits in Patients with Amnestic Mild Cognitive Impairment

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    Background: Anatomical and functional deficits have been studied in patients with amnestic mild cognitive impairment (MCI). However, it is unclear whether and how the anatomical deficits are related to the functional alterations. Present study aims to characterize the association between anatomical and functional deficits in MCI patients. Methods: Seventeen amnestic MCI patients and 18 healthy aging controls were scanned using a T1 Weighted MPRAGE sequence and a gradient-echo echo-planar imaging sequence. Clinical severity of MCI patients was evaluated by usin

    Quantification of Systemic Interference in Optical Topography Data during Frontal Lobe and Motor Cortex Activation: An Independent Component Analysis

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    Functional near-infrared optical topography (OT) is used to non-invasively measure the changes in oxygenated and deoxygenated haemoglobin (Delta[HbO(2)], Delta[HHb]) and hence investigate the brain haemodynamic changes, which occur in response to functional activation at specific regions of the cerebral cortex. However, when analysing functional OT data the task-related systemic changes should be taken into account. Here we used an independent component analysis (ICA) method on the OT [HbO(2)] signal, to determine the task-related independent components and then compared them with the systemic measurements (blood pressure, heart rate, scalp blood flow) to assess whether the components are due to systemic noise or neuronal activation. This analysis can therefore extract the true OT haemodynamic neuronal response and hence discriminate between regional activated cortical areas and global haemodynamic changes

    Physiological and Pathological Roles of 15-Deoxy-Δ12,14-Prostaglandin J2 in the Central Nervous System and Neurological Diseases

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