Endothelial dysfunction predicted increased left atrial volume index in newly diagnosed nondiabetic hypertensive patients

PubMed: 31764010Background Arterial hypertension is associated with cardiovascular morbidity and mortality. It was previously shown that left atrium volume increase associated with mortality and atherosclerotic heart disease. The aim of the present study was to demonstrate the value of endothelial dysfunction in predicting left atrium volume increase in newly diagnosed hypertension patients. Methods This study included 96 consecutive newly diagnosed hypertensive patients. Left atrium volume and left ventricular ejection fraction were calculated. Pulse wave velocity and brachial artery flow-mediated dilation measurements were obtained from each patient. Results Left Ventricle Mass Index (114 ± 29 g/m2, 91 ± 17 g/m2, P < 001), left ventricular septum (P < 0.001) and posterior wall thickness (P = 0.001), left ventricular end diastolic diameter (P = 0.016) were significantly higher in patients with higher left atrial volume index. FMD% was lower in patients with higher left atrial volume index those without (9.7 ± 3.5 vs. 13.31 ± 6.01, P = 0.004). Lateral wall E wave velocity was significantly lower (8.68 ± 2.8, 10.2 ± 2.8; P = 0.009), while isovolumetric relaxation time (101.9 ± 19.9 ms, 85.7 ± 15.2 ms; P < 0.001), and ejection time was longer (101.9 ± 19.9 ms, 85.7 ± 15.2 ms; P = 0.077) and Mitral E/ lateral wall E ratio (E/E relation) was significantly higher (P = 0.031) in patients with higher left atrial volume index. Conclusion The rate of isovolumetric relaxation time, FMD% and E/E? ratio independently predicted left atrial volume index increase in newly diagnosed hypertension patients. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved

Prädiktiver Wert des Fibrinogen-Albumin-Quotienten beim akuten Koronarsyndrom

PubMed: 31388710Background: We aimed to investigate the predictive value of the fibrinogen-to-albumin ratio (FAR) regarding the development of major cardiovascular events (MACE) in patients treated with percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS). Methods: This was a prospective, observational cohort study that included 261 consecutive patients who were treated with PCI. The patients were grouped according to the occurrence of MACE during the follow-up period. Results: During follow-up, MACE occurred in 68 (26%) patients. The FAR was independently predictive of MACE (HR: 1.017, 95% CI: 1.010–1.024, p?< 0.001). In addition, left ventricular ejection fraction (LVEF) and a diagnosis of ST-segment elevation myocardial infarction (STEMI) were independent predictors of MACE. The area under the curve (AUC) of the multivariable model, including LVEF and diagnosis of STEMI, was 0.707 (95% CI: 0.631–0.782, p?< 0.001). When the FAR was added to the multivariable model, the AUC was 0.770 (95% CI: 0.702–0.838, z?= 2.820, difference p?= 0.0048). Conclusion: The FAR could be used for the prediction of MACE in patients with ACS who have undergone PCI. © 2019, Springer Medizin Verlag GmbH, ein Teil von Springer Nature