STOCHASTIC COOLING DEVELOPMENTS FOR HESR AT FAIR

Abstract The option of heavy ion stochastic momentum cooling is investigated under the constraint of the present concept of the HESR. The simulations include the beam-target interaction due to a Hydrogen and Xenon target at injection energy 740 MeV/u and at 2 GeV/u. The capability of momentum Filter cooling is envisaged and at lower energies where the revolution harmonics begin to overlap the possibility of TOF cooling is examined

A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion

10.1371/journal.ppat.1003297PLoS Pathogens94

Chemotactic and Inflammatory Responses in the Liver and Brain Are Associated with Pathogenesis of Rift Valley Fever Virus Infection in the Mouse

Rift Valley fever virus (RVFV) is a major human and animal pathogen associated with severe disease including hemorrhagic fever or encephalitis. RVFV is endemic to parts of Africa and the Arabian Peninsula, but there is significant concern regarding its introduction into non-endemic regions and the potentially devastating effect to livestock populations with concurrent infections of humans. To date, there is little detailed data directly comparing the host response to infection with wild-type or vaccine strains of RVFV and correlation with viral pathogenesis. Here we characterized clinical and systemic immune responses to infection with wild-type strain ZH501 or IND vaccine strain MP-12 in the C57BL/6 mouse. Animals infected with live-attenuated MP-12 survived productive viral infection with little evidence of clinical disease and minimal cytokine response in evaluated tissues. In contrast, ZH501 infection was lethal, caused depletion of lymphocytes and platelets and elicited a strong, systemic cytokine response which correlated with high virus titers and significant tissue pathology. Lymphopenia and platelet depletion were indicators of disease onset with indications of lymphocyte recovery correlating with increases in G-CSF production. RVFV is hepatotropic and in these studies significant clinical and histological data supported these findings; however, significant evidence of a pro-inflammatory response in the liver was not apparent. Rather, viral infection resulted in a chemokine response indicating infiltration of immunoreactive cells, such as neutrophils, which was supported by histological data. In brains of ZH501 infected mice, a significant chemokine and pro-inflammatory cytokine response was evident, but with little pathology indicating meningoencephalitis. These data suggest that RVFV pathogenesis in mice is associated with a loss of liver function due to liver necrosis and hepatitis yet the long-term course of disease for those that might survive the initial hepatitis is neurologic in nature which is supported by observations of human disease and the BALB/c mouse model

Influence of adsorbed hydrogen molecules on the hydrogen permeation and recycling

SIGLECopy held by FIZ Karlsruhe; available from UB/TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Valuation of the safety concept of the combined nuclear/chemical complex for hydrogen production with HTTR

The high-temperature engineering test reactor (HTTR) in Oarai, Japan, will be worldwide the first plant to demonstrate the production of hydrogen by applying the steam reforming process and using nuclear process heat as primary energy. Particular safety aspects for such a combined nuclear/chemical complex have to be investigated to further detail. One of these special aspects is the fire and explosion hazard associated with the presence of flammable gases including a large LNG storage tank in close vicinity to the reactor building. A special focus is laid upon the conceivable development of a detonation pressure wave and its damaging effect on the reactor building. A literature study has shown that methane is a comparatively slow reacting gas and that a methane vapor cloud in the open atmosphere or partially obstructed areas is highly unlikely to result in a detonation if inadvertently released and ignited. Various theoretical assessments and experimental studies, which have been conducted in the past and which are of significance for the HTTR-steam reforming system, include the spreading and combustion behavior of cryogenic liquids and flammable gas mixtures providing the basis of a comprehensive safety analysis of the combined nuclear/chemical facility. (orig.)SIGLEAvailable from TIB Hannover: RA 831(4135) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Innovative Strategien zur Expansion hematopoietischer Stamm- und Vorlaeuferzellen im klinisch relevanten Massstab

Available from TIB Hannover: RA 831(4111) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Keramische Protonenleiter mit perowskitartiger Struktur

Some aliovalently doped perovskites like SrCe_0_._9_5Yb_0_._0_5O_3_-_#alpha# or BaCe_0_._9_0Nd_0_._0_5O_3_-_#alpha# dissolve significant amounts of water and become proton conducting. These ceramics are promising electrolytes in solid oxide fuel cells (SOFC), where hydrogen containing fuel is directly converted into electricity. This thesis efforts for a fundamental comprehension of the defect properties and the mechanism of the ionic transport. It contains the results of a number of independent solid state physical and electrochemical studies. For the first time measurements of magnetic properties, neutron diffraction and quasielastic neutron scattering are presented. Several new materials, pure and doped strontium-cerates, -zirconates and mixed creates-zirconates, were prepared and their morphology and composition thoroughly characterized. The incorporation of protons was investigated in a broad spectrum of gas phases. Measurements of the magnetic properties were performed at low temperatures (1.8 K<T<300 K). They gave the oxidation states and the concentrations of the different dopant-ions. The crystal structures of the ceramics were obtained by means of X-ray and neutron diffraction, which excellently complemented one another. The proton conductivity or diffusivity, respectively, was studied by impedance spectroscopy (IS) and quasielastic neutron scattering (QENS). While the former method yielded a macroscopic proton diffusion coefficient, the latter method permitted to elucidate the microscopic proton diffusion mechanism. To describe the complex mechanism a two-state model was derived. It explains the diffusion consisting of a sequence of free diffusion and trapping/escape events with the Yb"3"+-ions acting as trapping centers. The model enables the calculation of the spatial and temporal parameters. The self-diffusion coefficient obtained with QENS agrees with the conductivity diffusion coefficient obtained with in-situ-IS considering the transport numbers. The transport of protons was proven by the cell voltages of concentration cells. Furthermore, mixed conduction was observed. In dependence of temperature and composition of the gas phase, protons, oxygen ions and (defect-)electrons determined the charge transport. The total conductivity of the ceramics was divided in the contribution from the bulk and the grain-boundary. The specific conductivity was fairly independent of the nature of the dopant-ion but depends on its concentration. The mixed perovskites show promising properties. The electrode/electrolyte interface was studied by means of current-potential curves and impedance spectroscopy under potential control. In oxygen-rich atmosphere the reaction at the interface consists at least of two processes, which show an apparent activation energy of179 refs.SIGLEAvailable from TIB Hannover: RA 831(3121) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Microcrystalline silicon solar cells prepared by 13.56 MHz PECVD Prerequisites for high quality material at high growth rates

Topic of this thesis was the development of thin film solar cells based on microcrystalline silicon prepared by 13.56 MHz PECVD (plasma-enhanced chemical vapor deposition) at high deposition rates. Comprehensive solar cell studies, which were accompanied by material studies, resulted in the identification of the most important prerequisites for high quality solar cells at high growth rates. During the development of solar cells in various pressure regimes, a high deposition pressure emerged as key parameter for good solar cell performance at high deposition rates. Plasma ignition at high deposition pressures (>10 Torr) was only possible at low electrode distances. Other important factors were a high total gas flow and a substrate temperature, which should not exceed #propor to#200 C. As alternative approach deposition by pulsed plasma excitation was investigated. At deposition rates up to #propor to#5 A/s efficiencies comparable to continuous excitation were achieved, at higher rates the efficiency significantly decreased. In summary we succeeded in developing high quality solar cells at high deposition rates. Highlights were solar cells with 9.1, 9.0 and 8.9% efficiency for deposition rates of 1, 3 and 4 A/s, respectively. At 9 A/s still a high efficiency of 7.9% was achieved. Furthermore we gained an understanding of the prerequisites regarding the plasma properties to achieve high growth rates and high quality material. (orig.)SIGLEAvailable from TIB Hannover: RA 831(4083) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Glukoselimitierung als Strategie zur Steigerung der Produktion von MUC1 und anderen rekombinanten Glykoproteinen mit CHO-Zellen

Available from TIB Hannover: RA 831(4112) / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman