1,405 research outputs found
Poly[[μ-1,4-bis(imidazol-1-ylmethyl)benzene]bis(μ4-cyclohexane-1,4-dicarboxylato)dinickel(II)]
The structure of the polymeric title compound, [Ni2(C8H10O4)2(C14H14N4)]n, features a five-coordinate NiII centre defined by four carboxylate O atoms from two different cyclohexane-1,4-dicarboxylate (chdc) ligands and an N atom from one end of a 1,4-bis(imidazol-1-ylmethyl)benzene (1,4-bix) molecule. The NO4 coordination geometry is distorted square-pyramidal with the N atom in the apical position. Each end of the chdc ligand links pairs of NiII atoms into a paddle-wheel assembly, i.e. Ni2(O2CR′)4. These are connected into rows owing to the bridging nature of the chdc ligands, and the rows are connected into a two-dimensional grid via the 1,4-bix ligands. The 1,4-bix ligand, which is disposed about a centre of inversion, is disorderd. Two positions of equal occupancy were discerned for the –H2C(C6H4)CH2– residue
The First Release of the CSTAR Point Source Catalog from Dome A, Antarctica
In 2008 January the 24th Chinese expedition team successfully deployed the
Chinese Small Telescope ARray (CSTAR) to DomeA, the highest point on the
Antarctic plateau. CSTAR consists of four 14.5cm optical telescopes, each with
a different filter (g, r, i and open) and has a 4.5degree x 4.5degree field of
view (FOV). It operates robotically as part of the Plateau Observatory, PLATO,
with each telescope taking an image every 30 seconds throughout the year
whenever it is dark. During 2008, CSTAR #1 performed almost flawlessly,
acquiring more than 0.3 million i-band images for a total integration time of
1728 hours during 158 days of observations. For each image taken under good sky
conditions, more than 10,000 sources down to 16 mag could be detected. We
performed aperture photometry on all the sources in the field to create the
catalog described herein. Since CSTAR has a fixed pointing centered on the
South Celestial Pole (Dec =-90 degree), all the sources within the FOV of CSTAR
were monitored continuously for several months. The photometric catalog can be
used for studying any variability in these sources, and for the discovery of
transient sources such as supernovae, gamma-ray bursts and minor planets.Comment: 1 latex file and 9 figures The paper is accepted by PAS
The sky brightness and transparency in i-band at Dome A, Antarctica
The i-band observing conditions at Dome A on the Antarctic plateau have been
investigated using data acquired during 2008 with the Chinese Small Telescope
ARray. The sky brightness, variations in atmospheric transparency, cloud cover,
and the presence of aurorae are obtained from these images. The median sky
brightness of moonless clear nights is 20.5 mag arcsec^{-2} in the SDSS
band at the South Celestial Pole (which includes a contribution of about 0.06
mag from diffuse Galactic light). The median over all Moon phases in the
Antarctic winter is about 19.8 mag arcsec^{-2}. There were no thick clouds in
2008. We model contributions of the Sun and the Moon to the sky background to
obtain the relationship between the sky brightness and transparency. Aurorae
are identified by comparing the observed sky brightness to the sky brightness
expected from this model. About 2% of the images are affected by relatively
strong aurorae.Comment: There are 1 Latex file and 14 figures accepted by A
B_c meson rare decays in the light-cone quark model
We investigate the rare decays
and in the framework of the
light-cone quark model (LCQM). The transition form factors are calculated in
the space-like region and then analytically continued to the time-like region
via exponential parametrization. The branching ratios and longitudinal lepton
polarization asymmetries (LPAs) for the two decays are given and compared with
each other. The results are helpful to investigating the structure of
meson and to testing the unitarity of CKM quark mixing matrix. All these
results can be tested in the future experiments at the LHC.Comment: 9 pages, 11 figures, version accepted for publication in EPJ
Anti-tumor effect of Liqi, a traditional Chinese medicine prescription, in tumor bearing mice
<p>Abstract</p> <p>Background</p> <p><it>Liqi</it>, an herbal preparation used in traditional Chinese medicine, has been used to treat cancer in China for centuries. We investigated the anti-tumor effects of liqi and their mechanisms in mice that had been xenografted with tumors.</p> <p>Methods</p> <p>Sarcoma 180 tumor, Lewis lung carcinoma, and SGC-7901 cells were implanted in BALB/c mice, C57BL/6 mice, and BALB/c nude mice, respectively. Liqi was administered to subgroups of these mice. The tumor weight and size were measured. Cell cycle analysis and T lymphocyte subsets were determined by flow cytometry. The activity of NK cells and TNF was tested using cytotoxicity assay on YAC-1 cells and L929 cells, respectively, and the activity of IL-2 was tested with an IL-2-dependent CTLL-2 cell proliferation assay. Platelet aggregation was monitored by measuring electric impedance, and the levels of thromboxane A2 (TXA<sub>2</sub>) and prostacyclin (PGI<sub>2</sub>) in blood were measured by <sup>125</sup>I-TXB<sub>2 </sub>and <sup>125</sup>I-Keto-PGF<sub>1α </sub>radioimmunoassay.</p> <p>Results</p> <p>The results showed that liqi inhibited tumor growth in tumor-implanted mice and arrested the cell proliferation in the G0/G1 phase and reduced the portion of cells in S and G2/M phase for SGC-7901 cells. Liqi increased the activity of NK cells and TNF-α, stimulated IL-2 production and activity, and regulated T lymphocyte subpopulations. Liqi inhibited the Lewis lung carcinoma metastasis by inhibiting platelet aggregation and normalizing the balance between TXA<sub>2 </sub>and PGI<sub>2</sub>.</p> <p>Conclusion</p> <p>All these findings demonstrated that liqi has an anti-tumor effect in vivo. The mechanism may be related to immune regulation and anticoagulation effects.</p
R497K polymorphism in epidermal growth factor receptor gene is associated with the risk of acute coronary syndrome
<p>Abstract</p> <p>Background</p> <p>Previous studies suggested that genetic polymorphisms in the epidermal growth factor receptor (EGFR) gene had been implicated in the susceptibility to some tumors and inflammatory diseases. EGFR has been recently implicated in vascular pathophysiological processes associated with excessive remodeling and atherosclerosis. Acute coronary syndrome (ACS) is a clinical manifestation of preceding atherosclerosis. Our purpose was to investigate the association of the EGFR polymorphism with the risk of ACS. In this context, we analyzed the HER-1 R497K and EGFR intron 1 (CA)<sub>n </sub>repeat polymorphisms in 191 patients with ACS and 210 age- and sex-matched controls in a Chinese population, using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) strategy and direct sequencing.</p> <p>Results</p> <p>There were significant differences in the genotype and allele distribution of R497K polymorphism of the EGFR gene between cases and controls. The <it>Lys </it>allele had a significantly increased risk of ACS compared with the <it>Arg </it>allele (adjusted OR = 1.49, 95% CI: 1.12–1.98, adjusted <it>P </it>= 0.006). However, no significant relationship between the number of (CA)<sub>n </sub>repeats of EGFR intron 1 (both alleles < 20 or any allele ≥ 20) and the risk of ACS was observed (adjusted OR = 0.97, 95% CI: 0.58–1.64, adjusted <it>P </it>= 0.911). Considering these two polymorphisms together, there was no statistically significant difference between the two groups.</p> <p>Conclusion</p> <p>R497K polymorphism of the EGFR gene is significantly associated with the risk of ACS. Our data suggests that R497K polymorphism may be used as a genetic susceptibility marker of the ACS.</p
Sensitivity to tumor development by TALEN-mediated Trp53 mutant genes in the susceptible FVB/N mice and the resistance C57BL/6 mice
Abstract
Background
This study was undertaken to compare the sensitivities of mice strains during tumor induction by transcription activator-like effector nucleases (TALEN)-mediated Trp53 mutant gene. Alterations of their tumorigenic phenotypes including survival rate, tumor formation and tumor spectrum, were assessed in FVB/N-Trp53em2Hwl/Korl and C57BL/6-Trp53em1Hwl/Korl knockout (KO) mice over 16weeks.
Results
Most of the physiological phenotypes factors were observed to be higher in FVB/N-Trp53em2Hwl/Korl KO mice than C57BL/6-Trp53em1Hwl/Korl KO mice, although there were significant differences in the body weight, immune organ weight, number of red blood cells, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), platelet count (PLT), total bilirubin (Bil-T) and glucose (Glu) levels in the KO mice relative to the wild type (WT) mice. Furthermore, numerous solid tumors were also observed in various regions of the surface skin of FVB/N-Trp53em2Hwl/Korl KO mice, but were not detected in C57BL/6-Trp53em1Hwl/Korl KO mice. The most frequently observed tumor in both the Trp53 KO mice was malignant lymphoma, while soft tissue teratomas and hemangiosarcomas were only detected in the FVB/N-Trp53em2Hwl/Korl KO mice.
Conclusions
Our results indicate that the spectrum and incidence of tumors induced by the TALEN-mediated Trp53 mutant gene is greater in FVB/N-Trp53em2Hwl/Korl KO mice than C57BL/6-Trp53em1Hwl/Korl KO mice over 16weeks
Observation of CR Anisotropy with ARGO-YBJ
The measurement of the anisotropies of cosmic ray arrival direction provides
important informations on the propagation mechanisms and on the identification
of their sources. In this paper we report the observation of anisotropy regions
at different angular scales. In particular, the observation of a possible
anisotropy on scales between 10 and 30
suggests the presence of unknown features of the magnetic fields the charged
cosmic rays propagate through, as well as potential contributions of nearby
sources to the total flux of cosmic rays. Evidence of new weaker few-degree
excesses throughout the sky region R.A. is
reported for the first time.Comment: Talk given at 12th TAUP Conference 2011, 5-9 September 2011, Munich,
German
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