The role of contactin-associated protein-like 2 in neurodevelopmental disease and human cerebral cortex evolution

The contactin-associated protein-like 2 (CNTNAP2) gene is associated with multiple neurodevelopmental disorders, including autism spectrum disorder (ASD), intellectual disability (ID), and specific language impairment (SLI). Experimental work has shown that CNTNAP2 is important for neuronal development and synapse formation. There is also accumulating evidence for the differential use of CNTNAP2 in the human cerebral cortex compared with other primates. Here, we review the current literature on CNTNAP2, including what is known about its expression, disease associations, and molecular/cellular functions. We also review the evidence for its role in human brain evolution, such as the presence of eight human accelerated regions (HARs) within the introns of the gene. While progress has been made in understanding the function(s) of CNTNAP2, more work is needed to clarify the precise mechanisms through which CNTNAP2 acts. Such information will be crucial for developing effective treatments for CNTNAP2 patients. It may also shed light on the longstanding question of what makes us human

The Potential of Different Forage Combinations for Green-Chop Silage

On the Canterbury Plains of New Zealand (NZ) there is an opportunity on cropping farms, between summer harvest and autumn/winter sowing, to grow forage crops to make high quality silage. Recently, cereal cultivars have been specifically bred for forage production and suitability for whole-crop silage (de Ruiter et al. 2002), and also high legume (e.g. sulla) content forage mixes have resulted in high quality silages with high lactic acid and soluble carbohydrate content (Niezen et al. 1998). This trial aimed to determine the yield potential of various cereal/legume forage mixtures summer sown and harvested for silage in autumn

Prognostic significance of high-grade dysplasia in colorectal adenomas.

Aim  Colonoscopy to detect and remove polyps has contributed to a reduction in colorectal carcinoma. Three-year follow up is recommended for patients considered to be at high risk (at least three adenomas, adenoma ≥ 1 cm, villous or high-grade features). Our study focused on patients diagnosed with high-grade dysplasia with regard to initial management and follow up. Method  A search of patients who had had endoscopic removal of a high-grade adenoma was carried out. Patients with the following were excluded: follow up of \u3c 1 year, polyposis syndromes, prior colon cancer and a diagnosis of adenocarcinoma within 6 months following initial diagnosis. Results  Eighty-three patients treated between 1999 and 2007 for high-grade dysplasia (HGD) in a colorectal adenoma were identified. Over a median follow-up period of 4 years, 53 (64%) developed further adenomatous polyps. Among these, 7% had an adenoma with HGD or an adenocarcinoma. In all these patients, the initial high-grade adenoma was \u3e 1 cm in diameter. Initial follow-up colonoscopy was performed on average 7 months following the initial diagnosis. Ten per cent of patients underwent prophylactic segmental resection, and 6% received argon laser therapy. Conclusion  The study demonstrates that patients who have a colorectal adenoma \u3e 1 cm with HGD may be at high risk of developing further adenomas with HGD or carcinoma. Close follow up is warranted

Constraints on narrow exotic states from K+p and K0_Lp scattering data

We consider the effect of exotic S=+1 resonances Theta+ and Theta++ on K+p elastic scattering data (total cross section) and the process K0_Lp-->K0_Sp. Data near the observed Theta+(1540) are examined for evidence of additional states. The width limit for a Theta++ state is reconsidered and shown to be much less than 1 MeV.Comment: 4 pages, 3 eps figures; minor corrections, one fig adde

Pentaquark as Kaon-Nucleon Resonance

Several recent experiments have reported evidence for a narrow feature in the K(+)-neutron system, an apparent resonant state ~ 100 MeV above threshold and with a width < 25 MeV. This state has been labelled as Theta(+) (previously as Z(*)), and because of the implied inclusion of a anti-strange quark, is referred to as a pentaquark, that is, five quarks within a single bag. We present an alternative explanation for such a structure, as a higher angular momentum resonance in the isospin zero K(+) -N system. One might call this an exit channel or a molecular resonance. In a non-relativistic potential model we find a possible candidate for the kaon-nucleon system with relative angular momentum L=3, while L=1 and 2 states possess centrifugal barriers too low to confine the kaon and nucleon in a narrow state at an energy so high above threshold. A rather strong state-dependence in the potential is essential, however, for eliminating an observable L=2 resonance at lower energies.Comment: 4 page

Spectrum of the Y=2 Pentaquarks

By assuming a mass formula for the spectrum of the Y=2 pentaquarks, where the chromo-magnetic interaction plays a main role, and identifying the lightest state with the Theta^+(1540), we predict a spectrum in good agreement with the few I=0 and I=1 candidates proposed in the past.Comment: 12 pages, 4 figures, LaTe

Similar promotion of Aβ(1-42 )fibrillogenesis by native apolipoprotein E ε3 and ε4 isoforms

The apolipoprotein E ε4 allele contributes to the genetic susceptibility underlying a large proportion (~40–60%) of typical, sporadic Alzheimer disease. Apolipoprotein E deficient mice made transgenic for human apolipoprotein E ε4 accumulate excess cerebral amyloid when compared to similarly prepared mice expressing human apolipoprotein E ε3. Therefore, it is important to search for relevant interactions(s) between apolipoprotein E ε4 and Aβ in order to clarify the biological role for apolipoprotein E ε4 in Alzheimer disease. Using a thioflavine T (ThT)-based assay, we have investigated the effects of native human apolipoprotein E isoforms on the kinetics of Aβ fibrillogenesis. No obvious profibrillogenic activity was detected in Aβ(1-40)-based assays of any native apolipoprotein E isoform. However, when ThT assays were repeated using Aβ(1-42), modest, but statistically significant, profibrillogenic activity was detected in both apolipoprotein E ε3- and apolipoprotein E ε4-containing media and was similar in magnitude for the two isoforms. These data demonstrate that native apolipoprotein E possesses "pathological chaperone"-type activity for Aβ: in other words, the data indicate that a chaperone-like misfolding reaction can occur between native apolipoprotein E and Aβ. However, the equipotent activities of the apolipoprotein E ε3 and ε4 isoforms suggests the possibility that either extended co-incubation of apolipoprotein E and Aβ, or, perhaps, the inclusion in the reaction of other fibrillogenesis-modulation co-factors (such as metal ions, or inflammatory mediators such as reactive oxygen species, α(2)-macroglobulin, apolipoprotein J, etc.) may be required for modeling in vitro the apolipoprotein E-isoform-specific-regulation of extracellular Aβ accumulation that occurs in vivo. Alternatively, other events, such as differential apolipoprotein E-isoform-mediated clearance of Aβ or of apolipoprotein E/Aβ complexes may underlie apolipoprotein E-isoform-dependent Aβ accumulation

Re-Inventing Public Education:The New Role of Knowledge in Education Policy-Making

This article focuses on the changing role of knowledge in education policy making within the knowledge society. Through an examination of key policy texts, the Scottish case of Integrated Children Services provision is used to exemplify this new trend. We discuss the ways in which knowledge is being used in order to re-configure education as part of a range of public services designed to meet individuals' needs. This, we argue, has led to a 'scientization' of education governance where it is only knowledge, closely intertwined with action (expressed as 'measures') that can reveal problems and shape solutions. The article concludes by highlighting the key role of knowledge policy and governance in orienting education policy making through a re-invention of the public role of education

Building mutual trust: a framework project for implementing EU common standards in legal interpreting and translation

This edited volume addresses the establishment of core competencies for legal interpreters and translators(LITs) in the European common area, guides to core interpreter training curricula, the training of interpreter trainers, guidance for judicial professionals on working through legal interpreters and an extensive training materials resource bank

Kaon-Nucleon Scattering Amplitudes and Z∗^*-Enhancements from Quark Born Diagrams

We derive closed form kaon-nucleon scattering amplitudes using the ``quark Born diagram" formalism, which describes the scattering as a single interaction (here the OGE spin-spin term) followed by quark line rearrangement. The low energy I=0 and I=1 S-wave KN phase shifts are in reasonably good agreement with experiment given conventional quark model parameters. For $k_{lab}> 0.7$ Gev however the I=1 elastic phase shift is larger than predicted by Gaussian wavefunctions, and we suggest possible reasons for this discrepancy. Equivalent low energy KN potentials for S-wave scattering are also derived. Finally we consider OGE forces in the related channels K$\Delta$, K$^*$N and K$^*\Delta$, and determine which have attractive interactions and might therefore exhibit strong threshold enhancements or ``Z$^*$-molecule" meson-baryon bound states. We find that the minimum-spin, minimum-isospin channels and two additional K$^*\Delta$ channels are most conducive to the formation of bound states. Related interesting topics for future experimental and theoretical studies of KN interactions are also discussed.Comment: 34 pages, figures available from the authors, revte