The Prognostic Effect of Ethnicity for Gastric and Esophageal Cancer: The Population-Based Experience in British Columbia, Canada

Background: Gastric and esophageal cancers are among the most lethal human malignancies. Their epidemiologyis geographically diverse. This study compares the survival of gastric and esophageal cancer patients amongseveral ethnic groups including Chinese, South Asians, Iranians and Others in British Columbia (BC), Canada.Methods: Data were obtained from the population-based BC Cancer Registry for patients diagnosed with invasiveesophageal and gastric cancer between 1984 and 2006. The ethnicity of patients was estimated according to theirnames and categorized as Chinese, South Asian, Iranian or Other. Cox proportional hazards regression analysis wasused to estimate the effect of ethnicity adjusted for patient sex and age, disease histology, tumor location, diseasestage and treatment.Results: The survival of gastric cancer patients was significantly different among ethnic groups. Chinese patientsshowed better survival compared to others in univariate and multivariate analysis. The survival of esophagealcancer patients was significantly different among ethnic groups when the data was analyzed by a univariate test(p = 0.029), but not in the Cox multivariate model adjusted for other patient and prognostic factors.Conclusions: Ethnicity may represent underlying genetic factors. Such factors could influence host-tumorinteractions by altering the tumor’s etiology and therefore its chance of spreading. Alternatively, genetic factorsmay determine response to treatments. Finally, ethnicity may represent non-genetic factors that affect survival.Differences in survival by ethnicity support the importance of ethnicity as a prognostic factor, and may provideclues for the future identification of genetic or lifestyle factors that underlie these observations

Convergence of resonances on thin branched quantum wave guides

We prove an abstract criterion stating resolvent convergence in the case of operators acting in different Hilbert spaces. This result is then applied to the case of Laplacians on a family X_\eps of branched quantum waveguides. Combining it with an exterior complex scaling we show, in particular, that the resonances on X_\eps approximate those of the Laplacian with ``free'' boundary conditions on $X_0$, the skeleton graph of X_\eps.Comment: 48 pages, 1 figur

Breast cancer treatment and ethnicity in British Columbia, Canada

<p>Abstract</p> <p>Background</p> <p>Racial and ethnic disparities in breast cancer incidence, stage at diagnosis, survival and mortality are well documented; but few studies have reported on disparities in breast cancer treatment. This paper compares the treatment received by breast cancer patients in British Columbia (BC) for three ethnic groups and three time periods. Values for breast cancer treatments received in the BC general population are provided for reference.</p> <p>Methods</p> <p>Information on patients, tumour characteristics and treatment was obtained from BC Cancer Registry (BCCR) and BC Cancer Agency (BCCA) records. Treatment among ethnic groups was analyzed by stage at diagnosis and time period at diagnosis. Differences among the three ethnic groups were tested using chi-square tests, Fisher exact tests and a multivariate logistic model.</p> <p>Results</p> <p>There was no significant difference in overall surgery use for stage I and II disease between the ethnic groups, however there were significant differences when surgery with and without radiation were considered separately. These differences did not change significantly with time. Treatment with chemotherapy and hormone therapy did not differ among the minority groups.</p> <p>Conclusion</p> <p>The description of treatment differences is the first step to guiding interventions that reduce ethnic disparities. Specific studies need to examine reasons for the observed differences and the influence of culture and beliefs.</p

Morphological evolution and galactic sizes in the L-Galaxies SA model

In this work we update theL-Galaxiessemi-analytic model (SAM) to better follow thephysical processes responsible for the growth of bulges via disc instabilities (leading to pseudo-bulges) and mergers (leading to classical bulges). We address the former by considering thecontribution of both stellar and gaseous discs in the stability of the galaxy, and we update thelatter by including dissipation of energy in gas-rich mergers. Furthermore, we introduce angularmomentum losses during cooling and find that an accurate match to the observed correlationbetween stellar disc scale length and mass atz∼0.0requires that the gas loses 20%of its initialspecific angular momentum to the corresponding dark matter halo during the formation of thecold gas disc. We reproduce the observed trends between the stellar mass and specific angularmomentum for both disc- and bulge-dominated galaxies, with the former rotating faster thanthe latter of the same mass. We conclude that a two-component instability recipe provides amorphologically diverse galaxy sample which matches the observed fractional breakdown ofgalaxies into different morphological types. This recipe also enables us to obtain an excellent fitto the morphology-mass relation and stellar mass function of different galactic types. Finally, we find that energy dissipation during mergers reduces the merger remnant sizes and allowsus to match the observed mass-size relation for bulge-dominated system