Propagation of the Heaviest UH-Cosmic Ray Nuclei

Our previous studies showed that the fragmentation cross sections of gold nuclei interacting in hydrogen have large variations between the values measured at 0.9 and 10.6 GeV/n, which has very significant implications on calculations of the propagation of the heaviest UH cosmic ray nuclei, such as Pb and Pt We have now completed a series of runs at the Brookhaven AGS using beams of gold nuclei of intermediate energy. The data from these runs will allow us to establish the excitation functions for these cross sections in a wide range of targets and hence model propagation more accurately than hitherto. In addition we will be able to study the energy dependence of nuclear charge pickup, electromagnetic dissociation and fission. Beams of gold nuclei with seven energies between 4.0 and 0.9 Ge V /n were studied interacting in targets ranging in mass from hydrogen to lead. We will present data on the cross sections derived from several of these beams and discuss some of the implications

The Phosphorus/Sulfur Abundance Ratio as a Test of Galactic Cosmic-Ray Source Models

Galactic cosmic-ray (GCR) elemental abundances display a fractionation compared to solar-system values that appears ordered by atomic properties such as the first ionization potential (FIP) or condensation temperature (volatility). Determining which parameter controls the observed fractionation is crucial to distinguish between GCR origin models. The Cosmic-Ray Isotope Spectrometer (CRIS) instrument on board NASA's Advanced Composition Explorer (ACE) spacecraft can measure the abundances of several elements that break the general correlation between FIP and volatility (e.g., Na, P, K, Cu, Zn, Ga, and Ge). Phosphorus is a particularly interesting case as it is a refractory (high condensation temperature) element with a FIP value nearly identical to that of its semi-volatile neighbor, sulfur. Using a leaky-box galactic propagation model we find that the P/S and Na/Mg ratios in the GCR source favor volatility as the controlling parameter

On the Low Energy Decrease in Galactic Cosmic Ray Secondary/Primary Ratios

Galactic cosmic ray (GCR) secondary/primary ratios such as B/C and (Sc+Ti+V)/Fe are commonly used to determine the mean amount of interstellar material through which cosmic rays travel before escaping from the Galaxy (Λ_(esc)). These ratios are observed to be energy-dependent, with a relative maximum at ~1 GeV/nucleon, implying a corresponding peak in Λ_(esc). The decrease in Λ_(esc) at energies above 1 GeV/nucleon is commonly taken to indicate that higher energy cosmic rays escape more easily from the Galaxy. The decrease in Λ_(esc) at energies <1 GeV/nuc is more controversial; suggested possibilities include the effects of a galactic wind or the effects of distributed acceleration of cosmic rays as they pass through the interstellar medium. We consider two possible explanations for the low energy decrease in Λ_(esc) and attempt to fit the combined, high-resolution measurements of secondary/primary ratios from ~0.1 to 35 GeV/nuc made with the CRIS instrument on ACE and the C2 experiment on HEAO-3. The first possibility, which hypothesizes an additional, local component of low-energy cosmic rays that has passed through very little material, is found to have difficulty simultaneously accounting for the abundance of both B and the Fe-secondaries. The second possibility, suggested by Soutoul and Ptuskin, involves a new form for Λ_(esc) motivated by their diffusion-convection model of cosmic rays in the Galaxy. Their suggested form for Λ_(esc)(E) is found to provide an excellent fit to the combined ACE and HEAO data sets

Quantitative live-cell imaging and computational modelling shed new light on endogenous WNT/CTNNB1 signaling dynamics

WNT/CTNNB1 signaling regulates tissue development and homeostasis in all multicellular animals, but the underlying molecular mechanism remains incompletely understood. Specifically, quantitative insight into endogenous protein behavior is missing. Here, we combine CRISPR/Cas9-mediated genome editing and quantitative live-cell microscopy to measure the dynamics, diffusion characteristics and absolute concentrations of fluorescently tagged, endogenous CTNNB1 in human cells under both physiological and oncogenic conditions. State-of-the-art imaging reveals that a substantial fraction of CTNNB1 resides in slow-diffusing cytoplasmic complexes, irrespective of the activation status of the pathway. This cytoplasmic CTNNB1 complex undergoes a major reduction in size when WNT/CTNNB1 is (hyper)activated. Based on our biophysical measurements, we build a computational model of WNT/CTNNB1 signaling. Our integrated experimental and computational approach reveals that WNT pathway activation regulates the dynamic distribution of free and complexed CTNNB1 across different subcellular compartments through three regulatory nodes: the destruction complex, nucleocytoplasmic shuttling, and nuclear retention

Constraints on cosmic-ray acceleration and transport from isotope observations

Observations from the Cosmic Ray Isotope Spectrometer (CRIS) on ACE have been used to derive constraints on the locations, physical conditions, and time scales for cosmic-ray acceleration and transport. The isotopic composition of Fe, Co, and Ni is very similar to that of solar system material, indicating that cosmic rays contain contributions from supernovae of both Type II and Type Ia. The electron-capture primary ^(59)Ni produced in supernovae has decayed, demonstrating that a time ≳10^5 yr elapses before acceleration of the bulk of the cosmic rays and showing that most of the accelerated material is derived from old stellar or interstellar material rather than from fresh supernova ejecta

Constraints on the nucleosynthesis of refractory nuclides in galactic cosmic rays

Abundances of the isotopes of the refractory elements Ca, Fe, Co, and Ni in the galactic cosmic-ray source are compared with corresponding abundances in solar-system matter. For the 12 nuclides considered, relative abundances agree to within a factor of 2, and typically within 20–30%. In addition, comparisons of cosmic-ray abundances with model calculations of supernova yields are used to argue that cosmic rays contain contributions from stars with a broad range of masses. Based on these and other results we suggest that cosmic rays probably represent a sample of contemporary interstellar matter, at least for refractory species

Measurements of the isotopes of lithium, beryllium, and boron from ACE/CRIS

The isotopes of lithium, beryllium, and boron (LiBeB) are known in nature to be produced primarily by CNO spallation and α-α fusion from interactions between cosmic rays and interstellar nuclei. While the dominant source of LiBeB isotopes in the present epoch is cosmic-ray interactions, other sources are known to exist, including the production of ^(7)Li from big bang nucleosynthesis. Precise observations of galactic cosmic-ray LiBeB in addition to accurate modeling of cosmic-ray transport can help to constrain the relative importance among the different production mechanisms. The Cosmic Ray Isotope Spectrometer (CRIS) on the Advanced Composition Explorer (ACE) has measured nuclei with 2 ≲ Z ≲ 30 in the energy range ~30–500 MeV/nucleon since 1997 with good statistical accuracy. We present measurements of the isotopic abundances of LiBeB and discuss these observations in the context of previous cosmic-ray measurements and spectroscopic observations

The cosmic-ray contribution to galactic abundances of the light elements: Interpretation of GCR LiBeB abundance measurements from ACE/CRIS

Inelastic collisions between the galactic cosmic rays (GCRs) and the interstellar medium (ISM) are responsible for producing essentially all of the light elements Li, Be, and B (LiBeB) observed in the cosmic rays. Previous calculations (e.g., [1]) have shown that GCR fragmentation can explain the bulk of the existing LiBeB abundance in the present day Galaxy. However, elemental abundances of LiBeB in old halo stars indicate inconsistencies with this explanation. We have used a simple leaky-box model to predict the cosmic-ray elemental and isotopic abundances of LiBeB in the present epoch. We conducted a survey of recent scientific literature on fragmentation cross sections and have calculated the amount of uncertainty they introduce into our model. The predicted particle intensities of this model were compared with high energy (E_(ISM) = 200–500 MeV/nucleon) cosmic-ray data from the Cosmic Ray Isotope Spectrometer (CRIS), which indicates fairly good agreement with absolute fluxes for Z ≥ 5 and relative isotopic abundances for all LiBeB species

Minute-of-Arc Resolution Gamma ray Imaging Experiment—MARGIE

MARGIE (Minute-of-Arc Resolution Gamma-ray Imaging Experiment) is a large area(∼104 cm2), wide field-of-view (∼1 sr), hard X-ray/gamma-ray (∼20–600 keV) coded-mask imaging telescope capable of performing a sensitive survey of both steady and transient cosmic sources. MARGIE has been selected for a NASA mission-concept study for an Ultra Long Duration (100 day) Balloon flight. We describe our program to develop the instrument based on new detector technology of either cadmium zinc telluride (CZT) semiconductors or pixellated cesium iodide (CsI) scintillators viewed by fast-timing bi-directional charge-coupled devices (CCDs). The primary scientific objectives are to image faint Gamma-Ray Bursts (GRBs) in near-real-time at the low intensity (high-redshift) end of the logN-logS distribution, thereby extending the sensitivity of present observations, and to perform a wide field survey of the Galactic plane