23 research outputs found

    Clonal Hematopoiesis is Associated With Protection From Alzheimer\u27s Disease

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    Clonal hematopoiesis of indeterminate potential (CHIP) is a premalignant expansion of mutated hematopoietic stem cells. As CHIP-associated mutations are known to alter the development and function of myeloid cells, we hypothesized that CHIP may also be associated with the risk of Alzheimer\u27s disease (AD), a disease in which brain-resident myeloid cells are thought to have a major role. To perform association tests between CHIP and AD dementia, we analyzed blood DNA sequencing data from 1,362 individuals with AD and 4,368 individuals without AD. Individuals with CHIP had a lower risk of AD dementia (meta-analysis odds ratio (OR) = 0.64, P = 3.8 × 1

    Feedback Control with Equilibrium Revision for CMG-Actuated Inverted Pendulum

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    International audienceThe chapter centers around the problem of design a feedback control for the control moment gyroscope (CMG)-actuated inverted pendulum with online equilibrium revision after the center of mass displacement. The methodology for the control synthesis is the linear–quadratic regulator. The equations of motion for the model of the inverted pendulum are derived. The control is synthesized and implemented both in an experimental plant and in a simulation model. The results of the experiment and simulation show the reliability of the synthesized control, which is proved to be able to deal with the center of mass displacement

    Electronic properties and phase transition in Kagome metal, Yb0.5Co3Ge3

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    The Kagome lattice is an important fundamental structure in condensed matter physics for investigating the interplay of electron correlation, topology, and frustrated magnetism. Recent work on Kagome metals in the AV3Sb5 (A = K, Rb, Cs) family, has shown a multitude of correlation-driven distortions, including symmetry breaking charge density waves and nematic superconductivity at low temperatures. Here we study the new Kagome metal Yb0.5Co3Ge3 and find a temperature-dependent kink in the resistivity that is highly similar to the AV3Sb5 behavior and is commensurate with an in-plane structural distortion of the Co Kagome lattice along with a doubling of the c-axis. The space group is found to lower from P6/mmm to P63/m below the transition temperature, breaking the in-plane mirror planes and C6 rotation, while gaining a screw axis along the c-direction. At very low temperatures, anisotropic negative magnetoresistance is observed, which may be related to anisotropic magnetism. This raises questions about the types of the distortions in Kagome nets and their resulting physical properties including superconductivity and magnetism
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