948 research outputs found
The Design and Testing of a High Performance Formula SAE Powertrain
Every year the Society of Automotive Engineers (SAE) tasks collegiate students with designing, constructing, testing, and competing with an open wheel formula style racecar. This vehicle has to meet stringent technical requirements that are provided in a rule book published by SAE. The Formula SAE (FSAE) rule book is a very comprehensive set of requirements that are centered on safety of the driver of the vehicle and the safety of the track workers. The students are required to read and understand the rulebook in order to use sound engineering practices to build not only a high performing vehicle but a safe one. There are several aspects of the competition series to test the students understanding and knowledge of their vehicle. There are not only dynamic events that test the dynamic performance of the vehicle, but static events that test the knowledge and understanding of the students.
The Zips Racing team at the University of Akron has been competing in the FSAE competition series since 1990. The team is on its 27th vehicle design since inception and has recently switched its powertrain from a 600cc Inline 4 engine to a 450cc single cylinder engine. This report will detail why and how the switch in powertrains was accomplished. The design of the powertrain package will include a detailed analysis as to the selection of the base engine to be used, general conceptual design (Normally Aspirated or Forced Induction), and then particular component design to fit the overall conceptual design. The next section that will be evaluated will be the construction of the particular powertrain components. This is where material selection and manufacturing processes will be evaluated for each part. Once the powertrain is designed and then constructed, it is important to ensure it is tested to verify the package meets the design requirements that were previously chosen. When the powertrain is finished being tested, it is then essential to implement the package into the entire vehicle design. This is where component packaging will be determined. While these sections have been separated into distinct categories, there are a very close tie between each of them. One cannot exist without the other and many times one is found repeating the process to improve on a previous iteration. Overall, the Zips Racing team’s powertrain package has proven to be a very high performance system that will deliver an overall win this year
Inactivation properties of sodium channel Nav1.8 maintain action potential amplitude in small DRG neurons in the context of depolarization
<p>Abstract</p> <p>Background</p> <p>Small neurons of the dorsal root ganglion (DRG) express five of the nine known voltage-gated sodium channels. Each channel has unique biophysical characteristics which determine how it contributes to the generation of action potentials (AP). To better understand how AP amplitude is maintained in nociceptive DRG neurons and their centrally projecting axons, which are subjected to depolarization within the dorsal horn, we investigated the dependence of AP amplitude on membrane potential, and how that dependence is altered by the presence or absence of sodium channel Na<sub>v</sub>1.8.</p> <p>Results</p> <p>In small neurons cultured from wild type (WT) adult mouse DRG, AP amplitude decreases as the membrane potential is depolarized from -90 mV to -30 mV. The decrease in amplitude is best fit by two Boltzmann equations, having V<sub>1/2 </sub>values of -73 and -37 mV. These values are similar to the V<sub>1/2 </sub>values for steady-state fast inactivation of tetrodotoxin-sensitive (TTX-s) sodium channels, and the tetrodotoxin-resistant (TTX-r) Na<sub>v</sub>1.8 sodium channel, respectively. Addition of TTX eliminates the more hyperpolarized V<sub>1/2 </sub>component and leads to increasing AP amplitude for holding potentials of -90 to -60 mV. This increase is substantially reduced by the addition of potassium channel blockers. In neurons from Na<sub>v</sub>1.8(-/-) mice, the voltage-dependent decrease in AP amplitude is characterized by a single Boltzmann equation with a V<sub>1/2 </sub>value of -55 mV, suggesting a shift in the steady-state fast inactivation properties of TTX-s sodium channels. Transfection of Na<sub>v</sub>1.8(-/-) DRG neurons with DNA encoding Na<sub>v</sub>1.8 results in a membrane potential-dependent decrease in AP amplitude that recapitulates WT properties.</p> <p>Conclusion</p> <p>We conclude that the presence of Na<sub>v</sub>1.8 allows AP amplitude to be maintained in DRG neurons and their centrally projecting axons even when depolarized within the dorsal horn.</p
High-fidelity quantum logic gates using trapped-ion hyperfine qubits
We demonstrate laser-driven two-qubit and single-qubit logic gates with
fidelities 99.9(1)% and 99.9934(3)% respectively, significantly above the
approximately 99% minimum threshold level required for fault-tolerant quantum
computation, using qubits stored in hyperfine ground states of calcium-43 ions
held in a room-temperature trap. We study the speed/fidelity trade-off for the
two-qubit gate, for gate times between 3.8s and 520s, and develop a
theoretical error model which is consistent with the data and which allows us
to identify the principal technical sources of infidelity.Comment: 1 trap, 2 ions, 3 nines. Detailed write-up of arXiv:1406.5473
including single-qubit gate data als
Secondary memory CD8+ T cells are more protective but slower to acquire a central–memory phenotype
The formation of memory CD8 T cells is an important goal of vaccination. However, although widespread use of booster immunizations in humans generates secondary and tertiary CD8 T cell memory, experimental data are limited to primary CD8 T cell memory. Here, we show that, compared with primary memory CD8 T cells, secondary memory CD8 T cells exhibit substantially delayed conversion to a central–memory phenotype, as determined by CD62L expression and interleukin (IL)-2 production. This delayed conversion to a central–memory phenotype correlates with reduced basal proliferation and responsiveness to IL-15, although in vitro coculture with a high concentration of IL-15 is capable of inducing proliferation and CD62L upregulation. Functionally, secondary memory CD8 T cells are more protective in vivo on a per cell basis, and this may be explained by sustained lytic ability. Additionally, secondary memory CD8 T cells are more permissive than primary memory CD8 T cells for new T cell priming in lymph nodes, possibly suggesting a mechanism of replacement for memory T cells. Thus, primary and secondary memory CD8 T cells are functionally distinct, and the number of encounters with antigen influences memory CD8 T cell function
High-fidelity trapped-ion quantum logic using near-field microwaves
We demonstrate a two-qubit logic gate driven by near-field microwaves in a
room-temperature microfabricated ion trap. We measure a gate fidelity of
99.7(1)\%, which is above the minimum threshold required for fault-tolerant
quantum computing. The gate is applied directly to Ca "atomic clock"
qubits (coherence time ) using the microwave
magnetic field gradient produced by a trap electrode. We introduce a
dynamically-decoupled gate method, which stabilizes the qubits against
fluctuating a.c.\ Zeeman shifts and avoids the need to null the microwave
field
A microfabricated ion trap with integrated microwave circuitry
We describe the design, fabrication and testing of a surface-electrode ion
trap, which incorporates microwave waveguides, resonators and coupling elements
for the manipulation of trapped ion qubits using near-field microwaves. The
trap is optimised to give a large microwave field gradient to allow
state-dependent manipulation of the ions' motional degrees of freedom, the key
to multiqubit entanglement. The microwave field near the centre of the trap is
characterised by driving hyperfine transitions in a single laser-cooled 43Ca+
ion.Comment: 4 pages, 5 figure
Magnetic field stabilization system for atomic physics experiments
Atomic physics experiments commonly use millitesla-scale magnetic fields to
provide a quantization axis. As atomic transition frequencies depend on the
amplitude of this field, many experiments require a stable absolute field. Most
setups use electromagnets, which require a power supply stability not usually
met by commercially available units. We demonstrate stabilization of a field of
14.6 mT to 4.3 nT rms noise (0.29 ppm), compared to noise of 100 nT
without any stabilization. The rms noise is measured using a field-dependent
hyperfine transition in a single Ca ion held in a Paul trap at the
centre of the magnetic field coils. For the Ca "atomic clock" qubit
transition at 14.6 mT, which depends on the field only in second order, this
would yield a projected coherence time of many hours. Our system consists of a
feedback loop and a feedforward circuit that control the current through the
field coils and could easily be adapted to other field amplitudes, making it
suitable for other applications such as neutral atom traps.Comment: 6 pages, 5 figure
High-fidelity preparation, gates, memory and readout of a trapped-ion quantum bit
We implement all single-qubit operations with fidelities significantly above
the minimum threshold required for fault-tolerant quantum computing, using a
trapped-ion qubit stored in hyperfine "atomic clock" states of Ca.
We measure a combined qubit state preparation and single-shot readout fidelity
of 99.93%, a memory coherence time of seconds, and an average
single-qubit gate fidelity of 99.9999%. These results are achieved in a
room-temperature microfabricated surface trap, without the use of magnetic
field shielding or dynamic decoupling techniques to overcome technical noise.Comment: Supplementary Information included. 6 nines, 7 figures, 8 page
Microwave control electrodes for scalable, parallel, single-qubit operations in a surface-electrode ion trap
We propose a surface ion trap design incorporating microwave control
electrodes for near-field single-qubit control. The electrodes are arranged so
as to provide arbitrary frequency, amplitude and polarization control of the
microwave field in one trap zone, while a similar set of electrodes is used to
null the residual microwave field in a neighbouring zone. The geometry is
chosen to reduce the residual field to the 0.5% level without nulling fields;
with nulling, the crosstalk may be kept close to the 0.01% level for realistic
microwave amplitude and phase drift. Using standard photolithography and
electroplating techniques, we have fabricated a proof-of-principle electrode
array with two trapping zones. We discuss requirements for the microwave drive
system and prospects for scalability to a large two-dimensional trap array.Comment: 8 pages, 6 figure
- …