A double-blind comparative study of the safety and efficacy of caspofungin versus micafungin in the treatment of candidiasis and aspergillosis

The safety and efficacy profile of caspofungin and micafungin in Japanese patients with fungal infections were directly compared in this prospective, randomized, double-blind study. The proportion of patients who developed significant drug-related adverse event(s) (defined as a serious drug-related adverse event or a drug-related adverse event leading to study therapy discontinuation) was compared in 120 patients [caspofungin 50 mg, or 50 mg following a 70-mg loading dose on Day 1 (hereinafter, 70/50 mg) group: 60 patients; micafungin 150 mg: 60 patients]. The overall response rate was primarily evaluated in the per-protocol set (PPS) population. The proportion of patients who developed significant drug-related adverse events was 5.0 % (3/60) in the caspofungin group and 10.0 % (6/60) in the micafungin group [95 % confidence interval (CI) for the difference: -15.9 %, 5.2 %]. The favorable overall response in the PPS population for patients with esophageal candidiasis, invasive candidiasis, and chronic pulmonary aspergillosis including aspergilloma was 100.0 % (6/6), 100.0 % (3/3), and 46.7 % (14/30) in the caspofungin group, and 83.3 % (5/6), 100.0 % (1/1), and 42.4 % (14/33) in the micafungin group, respectively. In Japanese patients with Candida or Aspergillus infections, there was no statistical difference in the safety between caspofungin and micafungin. Consistent with other data on these two agents, the efficacy of caspofungin and micafungin was similar

MARTENSITE TRANSFORMATIONS AND RELATED PROPERTIES OF MARMEM ALLOY RIBBONS PREPARED BY THE SPINNING ROLL METHOD

The melt spinning technique has been employed to refine the grain sizes of shape memory (marmem) alloys of Cu-Sn, Cu-Al-Ni, Cu-Zn, Cu-Zn-Al, Cu-Zn-Si and Ti-Ni. Ribbons 1-2 mm wide and 30-60 µm thick with grain sizes of up to 20 µm were obtained. Their martensite transformations and mechanical properties were investigated by optical and electron microscopy, X-ray diffractometry, electrical resistance measurements and mechanical tensile tests. Cu-Sn and Cu-Al-Ni ribbons exhibited the best shape memory effect, while Cu-Zn alloys gave different properties from specimen to specimen, because of variable alloy concentration due to vaporization loss of Zn. Good shape memory ribbons have not yet been prepared in Ti-Ni

Development of method to reduce radiation exposure to the large intestine during 223Ra alpha therapy with barium sulfate

Actinides2017に参加、口頭発表Actinides2017に参加、発