AhR, inflammation and breast cancer

Aryl hydrocarbon receptor (AhR), an evolutionary conserved transcription factor, is a pleiotropic signal transductor. Thanks to its promiscuous ligand binding domain, during the evolution of eukaryotic cells its developmental functions were integrated with biosensor functions. Its activation by a multitude of endogenous and exogenous molecules stimulates its participation in several pathways, some of which are linked to inflammation and breast cancer (BC). Over time, the study of this malignancy has led to the identification of several therapeutic targets in cancer cells. An intense area of study is dedicated to BC phenotypes lacking adequate targets. In this context, due to its high constitutive activation in BC, AhR is currently gaining more and more attention

Thermodynamics of precision in quantum nanomachines

Fluctuations strongly affect the dynamics and functionality of nanoscale thermal machines. Recent developments in stochastic thermodynamics have shown that fluctuations in many far-from-equilibrium systems are constrained by the rate of entropy production via so-called thermodynamic uncertainty relations. These relations imply that increasing the reliability or precision of an engine's power output comes at a greater thermodynamic cost. Here we study the thermodynamics of precision for small thermal machines in the quantum regime. In particular, we derive exact relations between the power, power fluctuations, and entropy production rate for several models of few-qubit engines (both autonomous and cyclic) that perform work on a quantized load. Depending on the context, we find that quantum coherence can either help or hinder where power fluctuations are concerned. We discuss design principles for reducing such fluctuations in quantum nanomachines and propose an autonomous three-qubit engine whose power output for a given entropy production is more reliable than would be allowed by any classical Markovian model

On The Distribution Of Siphonops Paulensis Boettger, 1892 (gymnophiona: Siphonopidae): Four New Brazilian State Records

Siphonops paulensis Boettger, 1892 is a Neotropical siphonopid caecilian widely distributed in South America. Herein, we fill knowledge gaps in the distribution of S. paulensis mostly in northeastern Brazil, including four new state records. © 2016 Check List and Authors.12