Tebentafusp in Patients with Metastatic Uveal Melanoma: A Real-Life Retrospective Multicenter Study

Background: Tebentafusp has recently been approved for the treatment of metastatic uveal melanoma (mUM) after proving to have survival benefits in a first-line setting. Patients and Methods: This retrospective, multicenter study analyzed the outcomes and safety of tebentafusp therapy in 78 patients with mUM. Results: Patients treated with tebentafusp had a median PFS of 3 months (95% CI 2.7 to 3.3) and a median OS of 22 months (95% CI 10.6 to 33.4). In contrast to a published Phase 3 study, our cohort had a higher rate of patients with elevated LDH (65.4% vs. 35.7%) and included patients with prior systemic and local ablative therapies. In patients treated with tebentafusp following ICI, there was a trend for a longer median OS (28 months, 95% CI 26.9 to 29.1) compared to the inverse treatment sequence (24 months, 95% CI 13.0 to 35.0, p = 0.257). The most common treatment-related adverse events were cytokine release syndrome in 71.2% and skin toxicity in 53.8% of patients. Tumor lysis syndrome occurred in one patient. Conclusions: Data from this real-life cohort showed a median PFS/OS similar to published Phase 3 trial data. Treatment with ICI followed by tebentafusp may result in longer PFS/OS compared to the inverse treatment sequence

Urban physics simulation for climate change adaptation of buildings and urban areas

This chapter discusses the simulation of urban thermal microclimate with a focus on heat waves in urban areas, the simulation of overheating of buildings and the effects of adaptation measures to limit temperatures in buildings and urban areas during heat waves. The spatial scales are the meteorological microscale (neighborhood scale) and the building scale; the methods are computational fluid dynamics and building energy simulation. Adaptation measures investigated at the neighborhood scale are avenue trees, green facades and green roofs; adaptation measures at the building scale are increased thermal resistance, increased thermal mass, increased short-wave reflectivity of facades and roofs, peak ventilation, vegetated roofs and exterior solar shading