30 research outputs found
Inform Me When It Matters: Cost Salience, Energy Consumption, and Efficiency Investments
Solution Structure of CCL21 and Identification of a Putative CCR7 Binding Site
CCL21 is a human chemokine that recruits normal immune
cells and
metastasizing tumor cells to lymph nodes through activation of the
G protein-coupled receptor CCR7. The CCL21 structure solved by NMR
contains a conserved chemokine domain followed by an extended, unstructured
C-terminus that is not typical of most other chemokines. A sedimentation
equilibrium study showed CCL21 to be monomeric. Chemical shift mapping
indicates that the CCR7 N-terminus binds to the N-loop and third β-strand
of CCL21’s chemokine domain. Details of CCL21-receptor recognition
may enable structure-based drug discovery of novel antimetastatic
agents