DIII-D data for modeling the scrape-off-layer plasma

We are in the process of assembling a database of edge and divertor plasma parameters suitable for use in benchmarking tious 2D models of the scrape-off- layer (SOL) plasma. Also, we are using the Braams B2 code to derive transport coefficients for the edge plssma. In parallel, work is starting on an upgrade to the B2 code that includes padlel current flow and EXB drifts. These efforts are directed at increasing the confidence level of models of the tokamak edge plasma so that we can predict the effect of planned upgrades to DIII-D (e.g., the Advanced Divertor Program) and the performance of next generation machines such as CIT or ITER, where initial design studies show that plasma conditions at the divertor targets can have a large impact on the lifetime and cost of the machine. This report summarizes our recent progress in characterizing the DIII-D SOL plasma and in modeling these data with the the B2 code. Section I contains a brief description of the diagnostics available for characterizing the SOL plasma. In Section II we present our measurements of the SOL parameters for H-mode plasmas. This includes data showing how the divertor plasma parameters (n{sub e}(r), T{sub e}(r), and Q(r)) vary from ohmic to L-mode to H-mode, and power balance for quasi-stationary H-mode plasmas. Section III covers divertor-target heat-flux asymmetries for double and single null operation with forward and reversed toroidal field. In Section IV we show the scaling of L-mode parameters with neutral beam power, and Section V concludes with a summary of the results obtained from the Braams B2 SOL simulation code

Identification of Antifungal Compounds Active against Candida albicans Using an Improved High-Throughput Caenorhabditis elegans Assay

Candida albicans, the most common human pathogenic fungus, can establish a persistent lethal infection in the intestine of the microscopic nematode Caenorhabditis elegans. The C. elegans–C. albicans infection model was previously adapted to screen for antifungal compounds. Modifications to this screen have been made to facilitate a high-throughput assay including co-inoculation of nematodes with C. albicans and instrumentation allowing precise dispensing of worms into assay wells, eliminating two labor-intensive steps. This high-throughput method was utilized to screen a library of 3,228 compounds represented by 1,948 bioactive compounds and 1,280 small molecules derived via diversity-oriented synthesis. Nineteen compounds were identified that conferred an increase in C. elegans survival, including most known antifungal compounds within the chemical library. In addition to seven clinically used antifungal compounds, twelve compounds were identified which are not primarily used as antifungal agents, including three immunosuppressive drugs. This assay also allowed the assessment of the relative minimal inhibitory concentration, the effective concentration in vivo, and the toxicity of the compound in a single assay

TFTR Mirnov coil analysis at plasma start-up

The methods for finding poloidal and toroidal numbers of MHD oscillations from Mirnov coils are reviewed and modified. Examples of various MHD phenomena occurring during start-up on TFTR are illustrated. It is found that the MHD mode structure best fits a model with the toroidal correction included. A new algorithm which finds m,n numbers can accommodate toroidal effects which are manifested in the phase data. The algorithm can find m,n numbers with a given toroidal correction parameter lambda', (lambda' = 0 cylindrical). This algorithm is also used to find the optimal value of lambda' automatically, eliminating the need for ''guesswork.'' The algorithm finds the best parameters to the fit much faster than more conventional computational techniques. 9 refs., 21 figs., 2 tabs