49 research outputs found
The new approach to a pattern recognition of volatile compounds: the inflammation markers in nasal mucus swabs from calves using the gas sensor array
This paper discusses the application of two approaches (direct and inverse) to the identification of volatile substances by means of a gas sensor array in a headspace over nasal mucus swab samples taken from calves with differing degrees of respiratory damage. We propose a unique method to visualize sensor array data for quality analysis, based on the spectra of cross mass sensitivity parameters. The traditional method, which requires an initial sensor array trained on the vapors of the individual substances (database accumulation)-with their further identification in the analyzed bio-samples through the comparison of the analysis results to the database-has shown unsatisfactory performance. The proposed inverse approach is more informative for the pattern recognition of volatile substances in the headspace of mucus samples. The projection of the calculated parameters of the sensor array for individual substances in the principal component space, acquired while processing the sensor array output from nasal swab samples, has allowed us to divide animals into groups according to the clinical diagnosis of their lung condition (healthy respiratory system, bronchitis, or bronchopneumonia). The substances detected in the gas phase of the nasal swab samples (cyclohexanone, butanone-2,4-methyl-2-pentanone) were correlated with the clinical state of the animals, and were consistent with the reference data on disease markers in exhaled air established for destructive organism processes
Features ofweb-publications for promotion of information services of UrFU
Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΈ ΠΠΈΡΠ΅ΠΊΡΠΈΠΈ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ Π£ΡΠ€Π£, ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π½ΡΠ΅ ΠΏΡΠΎΠ΄Π²ΠΈΠΆΠ΅Π½ΠΈΡ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΡΠ΅ΡΠ²ΠΈΡΠΎΠ². ΠΠΎΠΊΠ°Π·Π°Π½Ρ ΡΡΠΈΠ»ΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ°Π·Π»ΠΈΡΠΈΡ ΡΠ΅ΠΊΡΡΠΎΠ², ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½ΡΠ΅ΠΌΡΡ
ΠΏΠΎ ΡΠ°Π·Π½ΡΠΌ ΠΊΠ°Π½Π°Π»Π°ΠΌ ΠΈ ΡΠ°ΡΡΡΠΈΡΠ°Π½Π½ΡΡ
Π½Π° ΡΠ°Π·Π½ΡΡ ΡΠ΅Π»Π΅Π²ΡΡ Π°ΡΠ΄ΠΈΡΠΎΡΠΈΡ.Thearticle analyzes the publications of the Directorate of information technology, Ural Federal University, dedicated to advancing information services. The article shows the stylistic differences of the texts that are distributed through different channels and for different target audience
ΠΠΠ€ΠΠ ΠΠΠ’ΠΠΠΠΠ‘Π’Π¬ ΠΠ«Π₯ΠΠΠΠ«Π₯ Π‘ΠΠΠΠΠΠΠ Β«ΠΠΠΠΠ’Π ΠΠΠΠΠΠ ΠΠΠ‘ΠΒ» ΠΠ ΠΠ¬ΠΠΠΠ‘ΠΠΠ‘ΠΠ ΠΠ₯
The purpose of this research was assessing the influence of the various factors on the output signals of the static "electronic nose" based on the piezoelectric sensors, and determining the informative nature of these signals for the identification and determination of the marker-substances related to the pathogenic processes in the equilibrium gas phase over the aqueous solutions. Individual substances contained in bio samples in the presence of pathogenic and neoplastic processes, such as ammonia, amines, carboxylic acids, ethanol, 1-butanol, acetone, ethyl acetate, phenol, hydrogen sulfide and water were selected as the marker-substances. The selective coating of sensors was chosen based on the results of the numerous studies for the living systems of different nature in order to determine the deviations from the norm, which included standard chromatographic phases and specific sorbents (indicators, crown ethers). It was shown that the analytical information of the electronic nose based on the piezoelectric sensors no more dependent on the experimental conditions than other popular, widely used methods of analysis. The informative value of the sensors arrayβ output signals which were used to identify the substances was described. The array set of piezoelectric sensors identification parameters was established in order to detect amines, organic acids, alcohols, ethyl acetate, acetone in the equilibrium gas phase over the aqueous solutions. The influence of the sensors order in the array on the values of three-element identification parameters has been demonstrated. The scheme of the identification parameters application, including nonselective ones, has been proposed for detecting the organic substances coincidentally at least two parameters. The possibility of an application of these parameters to identify amines, acids, alcohols, ketones in the equilibrium gas phase over the aqueous solutions of mixtures from these substances has been proven. This approach was characterized by high sensitivity and specificity, and may be used for the identification of substances in equilibrium gas phase over the samples with high water content (blood, urine, lymph, perspiration, juices, beverages).Key words: piezoelectric sensors, electronic nose, analytical signals, marker-substances, identification parameters, informativenessDOI: http://dx.doi.org/10.15826/analitika.2017.21.2.001T.A. Kuchmenko and A.A. Shuba*Β Voronezh State University of Engineering Technologies, faculty of ecology and chemical technology, Revolution Avenue, 19, Voronezh, 394036, Russian FederationΒ ΠΠ±ΡΡΠΆΠ΄Π°Π΅ΡΡΡ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ, Π²Π»Π°ΠΆΠ½ΠΎΡΡΠΈ, ΡΠ΅ΠΆΠΈΠΌΠΎΠ² ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΡ, ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΡΡ
Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊ ΠΏΡΠ΅Π·ΠΎΡΠ΅Π·ΠΎΠ½Π°ΡΠΎΡΠΎΠ², ΠΏΡΠΈΡΠΎΠ΄Ρ ΠΈ ΠΌΠ°ΡΡΡ ΡΠΎΡΠ±Π΅Π½ΡΠ°, ΠΏΡΠΈΡΠΎΠ΄Ρ ΠΈ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ Π°Π½Π°Π»ΠΈΡΠ°, ΡΠΈΠΏΠ° ΠΏΡΠΎΠ± Π½Π° Π²ΡΡ
ΠΎΠ΄Π½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΠΌΠ°ΡΡΠΈΠ²Π° ΠΏΡΠ΅Π·ΠΎΡΠ΅Π½ΡΠΎΡΠΎΠ², Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ Π½Π° ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΡ, ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΠ΅ Π΄Π»Ρ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π²Π΅ΡΠ΅ΡΡΠ² Π² ΡΠΌΠ΅ΡΡΡ
, ΠΈ ΠΏΡΡΠΈ ΡΡΡΡΠ°Π½Π΅Π½ΠΈΡ ΠΈΠ»ΠΈ ΠΌΠΈΠ½ΠΈΠΌΠΈΠ·Π°ΡΠΈΠΈ ΡΡΠΎΠ³ΠΎ Π²Π»ΠΈΡΠ½ΠΈΡ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡ Β«ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎΠ³ΠΎ Π½ΠΎΡΠ°Β» Π½Π° ΠΏΡΠ΅Π·ΠΎΡΠ΅Π½ΡΠΎΡΠ°Ρ
Π½Π΅ Π±ΠΎΠ»Π΅Π΅ Π·Π°Π²ΠΈΡΠΈΠΌΠ° ΠΎΡ ΡΡΠ»ΠΎΠ²ΠΈΠΉ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°, ΡΠ΅ΠΌ ΠΏΠΎΠΏΡΠ»ΡΡΠ½ΡΠ΅, ΡΠΈΡΠΎΠΊΠΎ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ Π°Π½Π°Π»ΠΈΠ·Π°. ΠΠΏΠΈΡΠ°Π½Π° ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠ²Π½ΠΎΡΡΡ Π²ΡΡ
ΠΎΠ΄Π½ΡΡ
ΡΠΈΠ³Π½Π°Π»ΠΎΠ² ΠΌΠ°ΡΡΠΈΠ²Π° ΡΠ΅Π½ΡΠΎΡΠΎΠ², ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΡ
Π΄Π»Ρ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π²Π΅ΡΠ΅ΡΡΠ². Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Ρ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΡ ΠΌΠ°ΡΡΠΈΠ²Π° ΠΏΡΠ΅Π·ΠΎΡΠ΅Π½ΡΠΎΡΠΎΠ² Π΄Π»Ρ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΡ Π°ΠΌΠΈΠ½ΠΎΠ², ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΊΠΈΡΠ»ΠΎΡ, ΡΠΏΠΈΡΡΠΎΠ², ΡΡΠΈΠ»Π°ΡΠ΅ΡΠ°ΡΠ°, Π°ΡΠ΅ΡΠΎΠ½Π° Π² ΡΠ°Π²Π½ΠΎΠ²Π΅ΡΠ½ΠΎΠΉ Π³Π°Π·ΠΎΠ²ΠΎΠΉ ΡΠ°Π·Π΅ Π½Π°Π΄ Π²ΠΎΠ΄Π½ΡΠΌΠΈ ΡΠ°ΡΡΠ²ΠΎΡΠ°ΠΌΠΈ. ΠΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΏΠΎΡΡΠ΄ΠΊΠ° ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡ ΡΠ΅Π½ΡΠΎΡΠΎΠ² Π² ΠΌΠ°ΡΡΠΈΠ²Π΅ Π½Π° Π·Π½Π°ΡΠ΅Π½ΠΈΡ ΡΡΠ΅Ρ
ΡΠ»Π΅ΠΌΠ΅Π½ΡΠ½ΡΡ
ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ². ΠΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π° ΡΡ
Π΅ΠΌΠ° ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ², Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ Π½Π΅ΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΡΡ
, Π΄Π»Ρ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΡ ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
Π²Π΅ΡΠ΅ΡΡΠ² ΠΏΠΎ ΡΠΎΠ²ΠΏΠ°Π΄Π΅Π½ΠΈΡ Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ Π΄Π²ΡΡ
ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ². ΠΠΎΠΊΠ°Π·Π°Π½Π° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π΄Π°Π½Π½ΡΡ
ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² Π΄Π»Ρ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π°ΠΌΠΈΠ½ΠΎΠ², ΠΊΠΈΡΠ»ΠΎΡ, ΡΠΏΠΈΡΡΠΎΠ², ΠΊΠ΅ΡΠΎΠ½ΠΎΠ² Π² ΡΠ°Π²Π½ΠΎΠ²Π΅ΡΠ½ΠΎΠΉ Π³Π°Π·ΠΎΠ²ΠΎΠΉ ΡΠ°Π·Π΅ Π½Π°Π΄ Π²ΠΎΠ΄Π½ΡΠΌΠΈ ΡΠ°ΡΡΠ²ΠΎΡΠ°ΠΌΠΈ ΠΈΡ
ΡΠΌΠ΅ΡΠ΅ΠΉ. ΠΠ°Π½Π½ΡΠΉ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ Π²ΡΡΠΎΠΊΠΎΠΉ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡΡ ΠΈ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΡΡ ΠΈ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ Π΄Π»Ρ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π²Π΅ΡΠ΅ΡΡΠ² Π² ΡΠ°Π²Π½ΠΎΠ²Π΅ΡΠ½ΠΎΠΉ Π³Π°Π·ΠΎΠ²ΠΎΠΉ ΡΠ°Π·Π΅ Π½Π°Π΄ ΠΏΡΠΎΠ±Π°ΠΌΠΈ Ρ Π±ΠΎΠ»ΡΡΠΈΠΌ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ΠΌ Π²ΠΎΠ΄Ρ (ΠΊΡΠΎΠ²Ρ,Β ΠΌΠΎΡΠ°, Π»ΠΈΠΌΡΠ°, ΠΏΠΎΡ, ΡΠΎΠΊΠΈ, Π½Π°ΠΏΠΈΡΠΊΠΈ).ΠΠ»ΡΡΠ΅Π²ΡΠ΅ ΡΠ»ΠΎΠ²Π°: ΠΏΡΠ΅Π·ΠΎΡΠ΅Π½ΡΠΎΡΡ, ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΡΠΉ Π½ΠΎΡ, Π²Π΅ΡΠ΅ΡΡΠ²Π°-ΠΌΠ°ΡΠΊΠ΅ΡΡ, Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠΈΠ³Π½Π°Π», ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΡ, ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠ²Π½ΠΎΡΡΡ.DOI: http://dx.doi.org/10.15826/analitika.2017.21.2.001
ΠΠ²Π°Π½ΡΠΎΠ²ΡΠ΅ ΡΠΎΡΠΊΠΈ: ΠΎΠΏΡΡ ΠΈ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π² Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ ΡΠΈΡΡΠ΅ΠΌΠ°Ρ
The article is of a review nature, in which the dynamics of publication activity is analyzed and the possibilities of using quantum dots to solve various analytical problems are evaluated. The attention is paid to both traditional and relatively rare areas of analytical application of these nanostructures. A brief review of the types, advantages and disadvantages of synthesis methods, the influence of external factors on the band gap and luminescence intensity of inorganic nanosized phosphors, quantum dots of different nature, is presented. The areas of application and the main tasks solved with the use of quantum dots are systematized. Their analytical characteristics, operational properties and ways of regulating them are discussed. An effective way to control the analytical properties of the systems based on quantum dots is a directional change of the affinity for components by varying the nature of the stabilizing or modifying shell. Semiconductor colloidal quantum dots coated with a larger bandgap shell were selected for analytical use as the most commonly used systems due to their good photostability and fluorescence quantum yield. The advantages and disadvantages of other types of shells, as well as ways of modifying them, are shown. Solutions for organic analysis and medical diagnostics are considered. Systems of quantum dots used as biosensors with various guiding agents are considered, and their properties, advantages and disadvantages compared. Little studied issues and solutions in the direction of using quantum dots for developing sensor systems and their use for non-invasive analysis of living systems based on the results of detection of volatile organic compounds are identified.Keywords: quantum dots, application, analysis, reviewΠ‘ΡΠ°ΡΡΡ Π½ΠΎΡΠΈΡ ΠΎΠ±Π·ΠΎΡΠ½ΡΠΉ Ρ
Π°ΡΠ°ΠΊΡΠ΅Ρ, Π² Π½Π΅ΠΉ Π°Π½Π°Π»ΠΈΠ·ΠΈΡΡΠ΅ΡΡΡ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ° ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ, ΠΎΡΠ΅Π½ΠΈΠ²Π°ΡΡΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΠ²Π°Π½ΡΠΎΠ²ΡΡ
ΡΠΎΡΠ΅ΠΊ Π΄Π»Ρ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π·Π°Π΄Π°Ρ. ΠΡΠΈ ΡΡΠΎΠΌ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΡΠ΄Π΅Π»ΡΠ΅ΡΡΡ ΠΊΠ°ΠΊ ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΡΠΌ, ΡΠ°ΠΊ ΠΈ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠ΅Π΄ΠΊΠΈΠΌ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡΠΌ Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΡΠΈΡ
Π½Π°Π½ΠΎΡΡΡΡΠΊΡΡΡ. ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ ΠΊΡΠ°ΡΠΊΠΈΠΉ ΠΎΠ±Π·ΠΎΡ ΡΠΈΠΏΠΎΠ², Π΄ΠΎΡΡΠΎΠΈΠ½ΡΡΠ² ΠΈ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΊΠΎΠ² ΡΠΏΠΎΡΠΎΠ±ΠΎΠ² ΡΠΈΠ½ΡΠ΅Π·Π°, Π²Π»ΠΈΡΠ½ΠΈΡ Π²Π½Π΅ΡΠ½ΠΈΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² Π½Π° ΡΠΈΡΠΈΠ½Ρ Π·Π°ΠΏΡΠ΅ΡΠ΅Π½Π½ΠΎΠΉ Π·ΠΎΠ½Ρ ΠΈ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΡ Π»ΡΠΌΠΈΠ½Π΅ΡΡΠ΅Π½ΡΠΈΠΈ Π½Π΅ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
Π½Π°Π½ΠΎΡΠ°Π·ΠΌΠ΅ΡΠ½ΡΡ
Π»ΡΠΌΠΈΠ½ΠΎΡΠΎΡΠΎΠ² - ΠΊΠ²Π°Π½ΡΠΎΠ²ΡΡ
ΡΠΎΡΠ΅ΠΊ ΡΠ°Π·Π½ΠΎΠΉ ΠΏΡΠΈΡΠΎΠ΄Ρ. Π‘ΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΠΎΠ±Π»Π°ΡΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΈ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ Π·Π°Π΄Π°ΡΠΈ, ΡΠ΅ΡΠ°Π΅ΠΌΡΠ΅ Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΠΊΠ²Π°Π½ΡΠΎΠ²ΡΡ
ΡΠΎΡΠ΅ΠΊ. ΠΠ±ΡΡΠΆΠ΄Π°ΡΡΡΡ ΠΈΡ
Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ, ΡΠΊΡΠΏΠ»ΡΠ°ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΠΈ ΡΠΏΠΎΡΠΎΠ±Ρ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΈΠΌΠΈ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ ΡΠΏΠΎΡΠΎΠ±ΠΎΠΌ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌΠΈ ΡΠΈΡΡΠ΅ΠΌ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΊΠ²Π°Π½ΡΠΎΠ²ΡΡ
ΡΠΎΡΠ΅ΠΊ ΡΠ²Π»ΡΠ΅ΡΡΡ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΠΎΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΡΠΎΠ΄ΡΡΠ²Π° ΠΊ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ°ΠΌ Π·Π° ΡΡΠ΅Ρ Π²Π°ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΈΡΠΎΠ΄Ρ ΡΡΠ°Π±ΠΈΠ»ΠΈΠ·ΠΈΡΡΡΡΠ΅ΠΉ ΠΈΠ»ΠΈ ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΡΡΡΠ΅ΠΉ ΠΎΠ±ΠΎΠ»ΠΎΡΠΊΠΈ. ΠΠ»Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Π² Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅Π»ΡΡ
Π²ΡΠ΄Π΅Π»Π΅Π½Ρ ΠΏΠΎΠ»ΡΠΏΡΠΎΠ²ΠΎΠ΄Π½ΠΈΠΊΠΎΠ²ΡΠ΅ ΠΊΠΎΠ»Π»ΠΎΠΈΠ΄Π½ΡΠ΅ ΠΊΠ²Π°Π½ΡΠΎΠ²ΡΠ΅ ΡΠΎΡΠΊΠΈ, ΠΏΠΎΠΊΡΡΡΡΠ΅ ΠΎΠ±ΠΎΠ»ΠΎΡΠΊΠΎΠΉ Ρ Π±ΠΎΠ»ΡΡΠ΅ΠΉ ΡΠΈΡΠΈΠ½ΠΎΠΉ Π·Π°ΠΏΡΠ΅ΡΠ΅Π½Π½ΠΎΠΉ Π·ΠΎΠ½Ρ, ΠΊΠ°ΠΊ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΡΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΠ΅ ΡΠΈΡΡΠ΅ΠΌΡ, Π±Π»Π°Π³ΠΎΠ΄Π°ΡΡ ΠΈΡ
Ρ
ΠΎΡΠΎΡΠΈΠΌ ΡΠΎΡΠΎΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ ΠΈ ΠΊΠ²Π°Π½ΡΠΎΠ²ΠΎΠΌΡ Π²ΡΡ
ΠΎΠ΄Ρ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠΈΠΈ. ΠΠΎΠΊΠ°Π·Π°Π½Ρ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π° ΠΈ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΊΠΈ Π΄ΡΡΠ³ΠΈΡ
ΡΠΈΠΏΠΎΠ² ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΠΊ, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠΏΠΎΡΠΎΠ±Ρ ΠΈΡ
ΠΌΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ. Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΡΠ΅ΡΠ΅Π½ΠΈΡ Π΄Π»Ρ ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΠΈ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ. Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΡΠΈΡΡΠ΅ΠΌΡ ΠΊΠ²Π°Π½ΡΠΎΠ²ΡΡ
ΡΠΎΡΠ΅ΠΊ, ΠΏΡΠΈΠΌΠ΅Π½ΡΠ΅ΠΌΡΠ΅ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π±ΠΈΠΎΡΠ΅Π½ΡΠΎΡΠΎΠ², Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌΠΈ Π½Π°ΠΏΡΠ°Π²Π»ΡΡΡΠΈΠΌΠΈ Π°Π³Π΅Π½ΡΠ°ΠΌΠΈ, ΡΠΎΠΏΠΎΡΡΠ°Π²Π»Π΅Π½Ρ ΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ²Π°, Π΄ΠΎΡΡΠΎΠΈΠ½ΡΡΠ²Π° ΠΈ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΊΠΈ. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΠΌΠ°Π»ΠΎ ΠΏΡΠΎΡΠ°Π±ΠΎΡΠ°Π½Π½ΡΠ΅ Π²ΠΎΠΏΡΠΎΡΡ ΠΈ ΡΠ΅ΡΠ΅Π½ΠΈΡ Π² Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΠ²Π°Π½ΡΠΎΠ²ΡΡ
ΡΠΎΡΠ΅ΠΊ Π΄Π»Ρ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ ΡΠ΅Π½ΡΠΎΡΠ½ΡΡ
ΡΠΈΡΡΠ΅ΠΌ, ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΈΡ
Π΄Π»Ρ Π½Π΅ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΠΆΠΈΠ²ΡΡ
ΡΠΈΡΡΠ΅ΠΌ ΠΏΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ Π΄Π΅ΡΠ΅ΠΊΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π»Π΅Π³ΠΊΠΎ Π»Π΅ΡΡΡΠΈΡ
ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ.ΠΠ»ΡΡΠ΅Π²ΡΠ΅ ΡΠ»ΠΎΠ²Π°: ΠΊΠ²Π°Π½ΡΠΎΠ²ΡΠ΅ ΡΠΎΡΠΊΠΈ, ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅, Π°Π½Π°Π»ΠΈΠ·, ΠΎΠ±Π·ΠΎ
ΠΠΠ‘ΠΠ ΠΠ‘Π‘ΠΠ«Π Π‘ΠΠΠ‘ΠΠ ΠΠΠΠΠΠΠ ΠΠ ΠΠΠΠΠ₯ Π‘ΠΠΠ Π’ΠΠ«Π₯ ΠΠΠΠΠ’ΠΠΠ ΠΠΠ‘Π‘ΠΠΠΠ ΠΠ¬ΠΠΠΠ‘ΠΠΠ‘ΠΠ ΠΠ Β«ΠΠΠΠΠ’Π ΠΠΠΠ«Π ΠΠΠ‘Β»
A new way of express analysis of alcohol-containing liquids with the possibility of identification of fusel oil set components using chemical gas sensors has been developed. The sorption of the volatile organic components of the basic alcohol-containing liquidsβ volatile fraction has been studied. The optimum set of piezosensors was chosen, and most importantly, it was adapted to the basic test substances (propanone, 1-propanol, 2-propanol, 1-butanol, 2-butanol, ethanol, butanone, acetaldehyde, ethyl acetate, butyl acetate, water). The possibility of applying an express method of piezoelectric quartz crystal micro-weighing for the identification of gross falsification of alcohol-containing beverages with the high ethanol content was positively evaluated. Several methodical approaches were offered to identify the individual vapor components in the mixture of fusel oils. The sample analysis of the alcohol-containing liquids was done simultaneously by the method of gas chromatography. The correlation between the area of the βvisual printβ signals, the optimized composition of chemical sensors and the parameters of gas chromatography was established. The newly developed method significantly reduces the time and the economic costs allowing you to quickly identify volatile organic substances in alcoholic beverages, and it is also helpful and suitable for the routine analysis.Keywords: the component of fusel oil, alcohol-containing liquids, quality, electronic nose, chemical sensorsDOI: http://dx.doi.org/10.15826/analitika.2017.21.3.003Β T.A. Kuchmenko, E.V. Bodrenko, E.P. AnokhinaVoronezh state university of engineering technologies, pr. Revoliutsii, 19, Voronezh, 394036, Russian FederationΠ Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΡΠΊΡΠΏΡΠ΅ΡΡΠ½ΡΠΉ ΡΠΏΠΎΡΠΎΠ± Π°Π½Π°Π»ΠΈΠ·Π° ΡΠΏΠΈΡΡΠΎΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
ΠΆΠΈΠ΄ΠΊΠΎΡΡΠ΅ΠΉ Π½Π°Π±ΠΎΡΠΎΠΌ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
Π³Π°Π·ΠΎΠ²ΡΡ
ΡΠ΅Π½ΡΠΎΡΠΎΠ² Ρ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ΠΌ ΠΏΡΠΎΠ± Π½ΠΈΠ·ΠΊΠΎΠ³ΠΎ ΠΊΠ°ΡΠ΅ΡΡΠ²Π°, ΡΠ°Π»ΡΡΠΈΡΠΈΠΊΠ°ΡΠΎΠ² ΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡΡ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² ΡΠΈΠ²ΡΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠ»Π° Π±Π΅Π· ΡΠ°Π·Π΄Π΅Π»Π΅Π½ΠΈΡ. ΠΠ·ΡΡΠ΅Π½Π° ΡΠΎΡΠ±ΡΠΈΡ Π»Π΅Π³ΠΊΠΎΠ»Π΅ΡΡΡΠΈΡ
ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ², Π²Ρ
ΠΎΠ΄ΡΡΠΈΡ
Π²Β ΠΎΡΠ½ΠΎΠ²Π½ΡΡ Π»Π΅Π³ΠΊΠΎΠ»Π΅ΡΡΡΡΡ ΡΡΠ°ΠΊΡΠΈΡ ΡΠΏΠΈΡΡΠΎΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
ΠΆΠΈΠ΄ΠΊΠΎΡΡΠ΅ΠΉ. ΠΡΠ±ΡΠ°Π½ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΡΠΉ Π½Π°Π±ΠΎΡ ΠΏΡΠ΅Π·ΠΎΡΠ΅Π½ΡΠΎΡΠΎΠ², ΠΊΠΎΡΠΎΡΡΠΉ Π°Π΄Π°ΠΏΡΠΈΡΠΎΠ²Π°Π½ ΠΊ ΠΎΡΠ½ΠΎΠ²Π½ΡΠΌ ΡΠ΅ΡΡ-Π²Π΅ΡΠ΅ΡΡΠ²Π°ΠΌ (ΠΏΡΠΎΠΏΠ°Π½ΠΎΠ½, ΠΏΡΠΎΠΏΠ°Π½ΠΎΠ»-1, ΠΏΡΠΎΠΏΠ°Π½ΠΎΠ»-2, Π±ΡΡΠ°Π½ΠΎΠ»-1, Π±ΡΡΠ°Π½ΠΎΠ»-2, ΡΡΠ°Π½ΠΎΠ», Π±ΡΡΠ°Π½ΠΎΠ½, Π°ΡΠ΅ΡΠ°Π»ΡΠ΄Π΅Π³ΠΈΠ΄, ΡΡΠΈΠ»Π°ΡΠ΅ΡΠ°Ρ, Π±ΡΡΠΈΠ»Π°ΡΠ΅ΡΠ°Ρ, Π²ΠΎΠ΄Π°). ΠΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΎΡΠ΅Π½Π΅Π½Π° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠ½ΠΎΠ³ΠΎ ΡΠΏΠΎΡΠΎΠ±Π° ΠΏΡΠ΅Π·ΠΎΠΊΠ²Π°ΡΡΠ΅Π²ΠΎΠ³ΠΎ ΠΌΠΈΠΊΡΠΎΠ²Π·Π²Π΅ΡΠΈΠ²Π°Π½ΠΈΡ Π΄Π»Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π³ΡΡΠ±ΡΡ
ΡΠ°Π»ΡΡΠΈΡΠΈΠΊΠ°ΡΠΎΠ² ΡΠΏΠΈΡΡΠΎΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
Π½Π°ΠΏΠΈΡΠΊΠΎΠ² Ρ Π²ΡΡΠΎΠΊΠΈΠΌ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ΠΌ ΡΡΠ°Π½ΠΎΠ»Π°. ΠΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Ρ Π΄Π»Ρ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π² ΡΠΌΠ΅ΡΠΈ ΠΏΠ°ΡΠΎΠ² ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΡ
ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² ΡΠΈΠ²ΡΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠ»Π°. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ ΠΏΠ»ΠΎΡΠ°Π΄ΡΡ Β«Π²ΠΈΠ·ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΡΠΏΠ΅ΡΠ°ΡΠΊΠ°Β» ΡΠΈΠ³Π½Π°Π»ΠΎΠ² Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅Π½ΡΠΎΡΠΎΠ² ΠΈ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠ°ΠΌΠΈ Π³Π°Π·ΠΎΠ²ΠΎΠΉ Ρ
ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠΈΠΈ. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½Π½ΡΠΉ ΡΠΏΠΎΡΠΎΠ± ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ ΡΠΌΠ΅Π½ΡΡΠ°Π΅Ρ Π²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ ΠΈ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π·Π°ΡΡΠ°ΡΡ ΡΡΡΠΈΠ½Π½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π°, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π² ΠΊΠΎΡΠΎΡΠΊΠΈΠ΅ ΡΡΠΎΠΊΠΈ Π²ΡΡΠ²ΠΈΡΡ ΡΠ°Π»ΡΡΠΈΡΠΈΠΊΠ°ΡΡ ΠΈ ΠΏΡΠΎΠ±Ρ, Π½Π΅ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠΈΠ΅ Π½ΠΎΡΠΌΠ°ΠΌ, ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ Π»Π΅Π³ΠΊΠΎΠ»Π΅ΡΡΡΠΈΠ΅ ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π²Π΅ΡΠ΅ΡΡΠ²Π° ΡΠΈΠ²ΡΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠ»Π° Π² Π°Π»ΠΊΠΎΠ³ΠΎΠ»ΡΠ½ΡΡ
Π½Π°ΠΏΠΈΡΠΊΠ°Ρ
Π±Π΅Π· ΡΠ°Π·Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΈ ΠΈΠ½ΠΎΠΉ ΠΏΡΠΎΠ±ΠΎΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ.ΠΠ»ΡΡΠ΅Π²ΡΠ΅ ΡΠ»ΠΎΠ²Π°: ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΡ ΡΠΈΠ²ΡΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠ»Π°,Β ΡΠΏΠΈΡΡΠΎΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΠ΅ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠΈ, ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎ, ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΡΠΉ Π½ΠΎΡ, Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ΅Π½ΡΠΎΡΡDOI: http://dx.doi.org/10.15826/analitika.2017.21.3.00
ΠΠ¦ΠΠΠΠ ΠΠΠ Π ΠΠΠ―Π¦ΠΠ Π‘ΠΠΠΠΠΠΠ Β«ΠΠΠΠΠ’Π ΠΠΠΠΠΠ ΠΠΠ‘ΠΒ» ΠΠΠ― ΠΠΠ‘ΠΠΠΠ Π‘ΠΠΠΠ Π ΠΠΠΠΠΠΠ‘ΠΠ’Π ΠΠ«ΠΠ«Π₯ΠΠΠΠΠΠ ΠΠΠΠΠ£Π₯Π Π’ΠΠΠ―Π’ Π‘ ΠΠΠΠΠΠ§ΠΠ‘ΠΠΠΠ Π ΠΠΠΠΠ ΠΠ’ΠΠ ΠΠ«ΠΠ ΠΠΠΠΠΠΠ’ΠΠΠ―ΠΠ
In this article the βelectronic noseβ system (SNT LLC, Russia) with an array of 8 differently selective piezoelectric sensors (nanobio array) was used to assess the health and functioning of the respiratory organs in young cattle by the fraction of volatile compounds over bioassays (exhaled breath condensate and nasal mucus). The sorption of the volatile fraction of substances vapors from the two types of bioassays was studied for 80s with the frontal effortless injection of vapors into the near-sensor space of the detection cell of the βelectronic noseβ at 20 Β± 1 ΒΊC with the subsequent fixation of the spontaneous desorption for 120s - total measurement time 200s . The simplest analytical signals of the "electronic nose" (SS ΠΈ Sneg) recorded and calculated in the software for the samples were proposed suitable for assessing the health of the respiratory organs in calves. A significant correlation was found between the analytical signals of the βelectronic noseβ and the established informative indicators of bovine respiratory diseases: increased activity of aspartate aminotransferase, alanine aminotransferase, creatinine in samples of exhaled breath condensate, respiratory failure index, and leukocyte count. The samples of nasal mucus were better used for the health assessment of the respiratory system using the nanobio array of sensors. Despite the initial small number of samples, the approach is universal and could be extended to the studies of other animals.Β Β Β Β Β Β Β Β Β Β Key words: piezosensors, βelectronic noseβ, correlation coefficient, nasal mucus, exhaled breath condensate, diagnosis, bovine respiratory disease, markers of inflammation(Russian)Β DOI: http://dx.doi.org/10.15826/analitika.2019.23.4.014T.A. Kuchmenko, A.A. Shuba1, R.U. Umarkhanov1, A.E. Chernitskii21Voronezh State University of Engineering Technologiesβ, pr. Revolutsii, 19, Voronezh, 394000, Russian Federation2All-Russian Scientific Research Veterinary Institute of Pathology, Pharmacology and Therapy, Research Center of Clinical Pharmacology and Therapy, Quality and Safety of Raw Materials and Products, st. Lomonosova, 114b, Voronezh, Russian FederationΠΠ±ΡΡΠΆΠ΄Π°Π΅ΡΡΡ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·Ρ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΡΡ
Π²ΡΡ
ΠΎΠ΄Π½ΡΡ
Π΄Π°Π½Π½ΡΡ
ΠΌΠ°ΡΡΠΈΠ²Π° ΡΠ΅Π½ΡΠΎΡΠΎΠ² (ΠΏΠ»ΠΎΡΠ°Π΄ΠΈ ΠΌΠ½ΠΎΠ³ΠΎΠΌΠ΅ΡΠ½ΡΡ
Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΈΠ³Π½Π°Π»ΠΎΠ² ΡΠ΅Π½ΡΠΎΡΠΎΠ² β Β«Π²ΠΈΠ·ΡΠ°Π»ΡΠ½ΡΡ
ΠΎΡΠΏΠ΅ΡΠ°ΡΠΊΠΎΠ²Β») Π² ΠΏΠ°ΡΠ°Ρ
Π±ΠΈΠΎΠΏΡΠΎΠ± ΡΠ΅Π»ΡΡ (Π½ΠΎΡΠΎΠ²Π°Ρ ΡΠ»ΠΈΠ·Ρ, ΠΊΠΎΠ½Π΄Π΅Π½ΡΠ°Ρ Π²ΡΠ΄ΡΡ
Π°Π΅ΠΌΠΎΠ³ΠΎ Π²ΠΎΠ·Π΄ΡΡ
Π°) Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΈ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ, ΡΠ²ΡΠ·Π°Π½Π½ΡΠΌΠΈ Ρ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΠ΅ΠΌ ΠΈΠ»ΠΈ Π½Π°Π»ΠΈΡΠΈΠ΅ΠΌ Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΉ, ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°ΡΡΠΈΠΌ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ ΠΎΡΠ³Π°Π½ΠΎΠ² Π΄ΡΡ
Π°Π½ΠΈΡ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΠΌΠ½ΠΎΠ³ΠΎΠΌΠ΅ΡΠ½ΡΠ΅ Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΈΠ³Π½Π°Π»Ρ ΠΌΠ°ΡΡΠΈΠ²Π° ΡΠ΅Π½ΡΠΎΡΠΎΠ² Π΄Π»Ρ ΡΠ°Π·Π½ΡΡ
Π²ΠΈΠ΄ΠΎΠ² Π±ΠΈΠΎΠΏΡΠΎΠ± Π½Π΅ ΠΊΠΎΡΡΠ΅Π»ΠΈΡΡΡΡ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠΎΠ±ΠΎΠΉ, Π½ΠΎ ΠΏΠΎ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ Π΄ΠΎΠ»ΠΈ ΡΡΡΠ΄Π½ΠΎ Π΄Π΅ΡΠΎΡΠ±ΠΈΡΡΡΡΠΈΡ
ΡΡ Π²Π΅ΡΠ΅ΡΡΠ² (ΠΊΠΈΡΠ»ΠΎΡΡ, ΡΠ°Π·Π²Π΅ΡΠ²Π»Π΅Π½Π½ΡΠ΅ Π°Π»ΠΈΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅, ΡΠΈΠΊΠ»ΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π°ΠΌΠΈΠ½Ρ) Π² ΠΎΠ±ΡΠ΅ΠΉ ΡΠΌΠ΅ΡΠΈ Π»Π΅Π³ΠΊΠΎΠ»Π΅ΡΡΡΠΈΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΎΡΠ΅Π½Π΅Π½Π° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ Π·Π°ΠΌΠ΅Π½Ρ ΠΏΡΠΎΠ± ΠΊΠΎΠ½Π΄Π΅Π½ΡΠ°ΡΠ° Π²ΡΠ΄ΡΡ
Π°Π΅ΠΌΠΎΠ³ΠΎ Π²ΠΎΠ·Π΄ΡΡ
Π° Π½Π° ΠΏΡΠΎΠ±Ρ Π½ΠΎΡΠΎΠ²ΠΎΠΉ ΡΠ»ΠΈΠ·ΠΈ, ΠΊΠΎΡΠΎΡΠ°Ρ ΠΎΡΠ±ΠΈΡΠ°Π΅ΡΡΡ Π±ΡΡΡΡΠΎ ΠΈ ΠΌΠ΅Π½Π΅Π΅ ΡΡΠ°Π²ΠΌΠ°ΡΠΈΡΠ½ΠΎ, Π΄Π»Ρ ΠΌΠΎΠ½ΠΈΡΠΎΡΠΈΠ½Π³Π° ΡΠΎΡΡΠΎΡΠ½ΠΈΡ Π·Π΄ΠΎΡΠΎΠ²ΡΡ Π²Π΅ΡΡ
Π½ΠΈΡ
Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΡΡ
ΠΏΡΡΠ΅ΠΉ ΠΌΠΎΠ»ΠΎΠ΄Π½ΡΠΊΠ° ΠΊΡΡΠΏΠ½ΠΎΠ³ΠΎ ΡΠΎΠ³Π°ΡΠΎΠ³ΠΎ ΡΠΊΠΎΡΠ°. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠ°Ρ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ ΠΎΡΠΊΠ»ΠΈΠΊΠ°ΠΌΠΈ ΠΌΠ°ΡΡΠΈΠ²Π° ΡΠ΅Π½ΡΠΎΡΠΎΠ² Π΄Π»Ρ ΠΏΡΠΎΠ± Π½ΠΎΡΠΎΠ²ΠΎΠΉ ΡΠ»ΠΈΠ·ΠΈ ΠΈ Π±ΠΈΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°ΠΊΡΠ° Π² ΠΊΠΎΠ½Π΄Π΅Π½ΡΠ°ΡΠ΅ Π²ΡΠ΄ΡΡ
Π°Π΅ΠΌΠΎΠ³ΠΎ Π²ΠΎΠ·Π΄ΡΡ
Π° (Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π°ΡΠΏΠ°ΡΡΠ°ΡΠ°ΠΌΠΈΠ½ΠΎΡΡΠ°Π½ΡΡΠ΅ΡΠ°Π·Ρ, Π°Π»Π°Π½ΠΈΠ½Π°ΠΌΠΈΠ½ΠΎΡΡΠ°Π½ΡΡΠ΅ΡΠ°Π·Ρ ΠΈ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡ ΠΊΡΠ΅Π°ΡΠΈΠ½ΠΈΠ½Π°), ΠΈΠ½Π΄Π΅ΠΊΡΠΎΠΌ Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΠΈ, ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ΠΌ Π»Π΅ΠΉΠΊΠΎΡΠΈΡΠΎΠ² Π² ΠΊΡΠΎΠ²ΠΈ. ΠΡΠΊΠ»ΠΈΠΊΠΈ ΡΠ΅Π½ΡΠΎΡΠΎΠ² Π΄Π»Ρ ΠΏΡΠΎΠ± Π½ΠΎΡΠΎΠ²ΠΎΠΉ ΡΠ»ΠΈΠ·ΠΈ ΡΠ²Π»ΡΡΡΡΡ Π±ΠΎΠ»Π΅Π΅ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠ²Π½ΡΠΌΠΈ Π΄Π»Ρ ΡΠ°Π½Π½Π΅ΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Ρ ΡΠ΅Π»ΡΡ.ΠΠ»ΡΡΠ΅Π²ΡΠ΅ ΡΠ»ΠΎΠ²Π°: ΠΏΡΠ΅Π·ΠΎΡΠ΅Π½ΡΠΎΡΡ, Β«ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΡΠΉ Π½ΠΎΡΒ», ΠΊΠΎΡΡΡΠΈΡΠΈΠ΅Π½Ρ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΈ, Π½ΠΎΡΠΎΠ²Π°Ρ ΡΠ»ΠΈΠ·Ρ, ΠΊΠΎΠ½Π΄Π΅Π½ΡΠ°Ρ Π²ΡΠ΄ΡΡ
Π°Π΅ΠΌΠΎΠ³ΠΎ Π²ΠΎΠ·Π΄ΡΡ
Π°, Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ°, ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΡΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΡΠ΅Π»ΡΡ, ΠΌΠ°ΡΠΊΠ΅ΡΡ Π²ΠΎΡΠΏΠ°Π»Π΅Π½ΠΈΡDOI: http://dx.doi.org/10.15826/analitika.2019.23.4.01
Informative nature of the electronic nose output signals based on the piezoelectric sensors
The purpose of this research was assessing the influence of the various factors on the output signals of the static βelectronic noseβ based on the piezoelectric sensors, and determining the informative nature of these signals for the identification and determination of the marker-substances related to the pathogenic processes in the equilibrium gas phase over the aqueous solutions. Individual substances contained in bio samples in the presence of pathogenic and neoplastic processes, such as ammonia, amines, carboxylic acids, ethanol, 1-butanol, acetone, ethyl acetate, phenol, hydrogen sulfide and water were selected as the marker-substances. The selective coating of sensors was chosen based on the results of the numerous studies for the living systems of different nature in order to determine the deviations from the norm, which included standard chromatographic phases and specific sorbents (indicators, crown ethers). It was shown that the analytical information of the electronic nose based on the piezoelectric sensors no more dependent on the experimental conditions than other popular, widely used methods of analysis. The informative value of the sensors arrayβ output signals which were used to identify the substances was described. The array set of piezoelectric sensors identification parameters was established in order to detect amines, organic acids, alcohols, ethyl acetate, acetone in the equilibrium gas phase over the aqueous solutions. The influence of the sensors order in the array on the values of three-element identification parameters has been demonstrated. The scheme of the identification parameters application, including nonselective ones, has been proposed for detecting the organic substances coincidentally at least two parameters. The possibility of an application of these parameters to identify amines, acids, alcohols, ketones in the equilibrium gas phase over the aqueous solutions of mixtures from these substances has been proven. This approach was characterized by high sensitivity and specificity, and may be used for the identification of substances in equilibrium gas phase over the samples with high water content (blood, urine, lymph, perspiration, juices, beverages).ΠΠ±ΡΡΠΆΠ΄Π°Π΅ΡΡΡ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΡ, Π²Π»Π°ΠΆΠ½ΠΎΡΡΠΈ, ΡΠ΅ΠΆΠΈΠΌΠΎΠ² ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΡ, ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΡΡ
Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊ ΠΏΡΠ΅Π·ΠΎΡΠ΅Π·ΠΎΠ½Π°ΡΠΎΡΠΎΠ², ΠΏΡΠΈΡΠΎΠ΄Ρ ΠΈ ΠΌΠ°ΡΡΡ ΡΠΎΡΠ±Π΅Π½ΡΠ°, ΠΏΡΠΈΡΠΎΠ΄Ρ ΠΈ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ Π°Π½Π°Π»ΠΈΡΠ°, ΡΠΈΠΏΠ° ΠΏΡΠΎΠ± Π½Π° Π²ΡΡ
ΠΎΠ΄Π½ΡΠ΅ Π΄Π°Π½Π½ΡΠ΅ ΠΌΠ°ΡΡΠΈΠ²Π° ΠΏΡΠ΅Π·ΠΎΡΠ΅Π½ΡΠΎΡΠΎΠ², Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ Π½Π° ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΡ, ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΠ΅ Π΄Π»Ρ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π²Π΅ΡΠ΅ΡΡΠ² Π² ΡΠΌΠ΅ΡΡΡ
, ΠΈ ΠΏΡΡΠΈ ΡΡΡΡΠ°Π½Π΅Π½ΠΈΡ ΠΈΠ»ΠΈ ΠΌΠΈΠ½ΠΈΠΌΠΈΠ·Π°ΡΠΈΠΈ ΡΡΠΎΠ³ΠΎ Π²Π»ΠΈΡΠ½ΠΈΡ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΡ Β«ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎΠ³ΠΎ Π½ΠΎΡΠ°Β» Π½Π° ΠΏΡΠ΅Π·ΠΎΡΠ΅Π½ΡΠΎΡΠ°Ρ
Π½Π΅ Π±ΠΎΠ»Π΅Π΅ Π·Π°Π²ΠΈΡΠΈΠΌΠ° ΠΎΡ ΡΡΠ»ΠΎΠ²ΠΈΠΉ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°, ΡΠ΅ΠΌ ΠΏΠΎΠΏΡΠ»ΡΡΠ½ΡΠ΅, ΡΠΈΡΠΎΠΊΠΎ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΡΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ Π°Π½Π°Π»ΠΈΠ·Π°. ΠΠΏΠΈΡΠ°Π½Π° ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠ²Π½ΠΎΡΡΡ Π²ΡΡ
ΠΎΠ΄Π½ΡΡ
ΡΠΈΠ³Π½Π°Π»ΠΎΠ² ΠΌΠ°ΡΡΠΈΠ²Π° ΡΠ΅Π½ΡΠΎΡΠΎΠ², ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΡ
Π΄Π»Ρ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π²Π΅ΡΠ΅ΡΡΠ². Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Ρ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΡ ΠΌΠ°ΡΡΠΈΠ²Π° ΠΏΡΠ΅Π·ΠΎΡΠ΅Π½ΡΠΎΡΠΎΠ² Π΄Π»Ρ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΡ Π°ΠΌΠΈΠ½ΠΎΠ², ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΊΠΈΡΠ»ΠΎΡ, ΡΠΏΠΈΡΡΠΎΠ², ΡΡΠΈΠ»Π°ΡΠ΅ΡΠ°ΡΠ°, Π°ΡΠ΅ΡΠΎΠ½Π° Π² ΡΠ°Π²Π½ΠΎΠ²Π΅ΡΠ½ΠΎΠΉ Π³Π°Π·ΠΎΠ²ΠΎΠΉ ΡΠ°Π·Π΅ Π½Π°Π΄ Π²ΠΎΠ΄Π½ΡΠΌΠΈ ΡΠ°ΡΡΠ²ΠΎΡΠ°ΠΌΠΈ. ΠΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΏΠΎΡΡΠ΄ΠΊΠ° ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡ ΡΠ΅Π½ΡΠΎΡΠΎΠ² Π² ΠΌΠ°ΡΡΠΈΠ²Π΅ Π½Π° Π·Π½Π°ΡΠ΅Π½ΠΈΡ ΡΡΠ΅Ρ
ΡΠ»Π΅ΠΌΠ΅Π½ΡΠ½ΡΡ
ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ². ΠΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π° ΡΡ
Π΅ΠΌΠ° ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΡ
ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ², Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ Π½Π΅ΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΡΡ
, Π΄Π»Ρ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΡ ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
Π²Π΅ΡΠ΅ΡΡΠ² ΠΏΠΎ ΡΠΎΠ²ΠΏΠ°Π΄Π΅Π½ΠΈΡ Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ Π΄Π²ΡΡ
ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ². ΠΠΎΠΊΠ°Π·Π°Π½Π° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π΄Π°Π½Π½ΡΡ
ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² Π΄Π»Ρ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π°ΠΌΠΈΠ½ΠΎΠ², ΠΊΠΈΡΠ»ΠΎΡ, ΡΠΏΠΈΡΡΠΎΠ², ΠΊΠ΅ΡΠΎΠ½ΠΎΠ² Π² ΡΠ°Π²Π½ΠΎΠ²Π΅ΡΠ½ΠΎΠΉ Π³Π°Π·ΠΎΠ²ΠΎΠΉ ΡΠ°Π·Π΅ Π½Π°Π΄ Π²ΠΎΠ΄Π½ΡΠΌΠΈ ΡΠ°ΡΡΠ²ΠΎΡΠ°ΠΌΠΈ ΠΈΡ
ΡΠΌΠ΅ΡΠ΅ΠΉ. ΠΠ°Π½Π½ΡΠΉ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ Π²ΡΡΠΎΠΊΠΎΠΉ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡΡ ΠΈ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΡΡ ΠΈ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ Π΄Π»Ρ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π²Π΅ΡΠ΅ΡΡΠ² Π² ΡΠ°Π²Π½ΠΎΠ²Π΅ΡΠ½ΠΎΠΉ Π³Π°Π·ΠΎΠ²ΠΎΠΉ ΡΠ°Π·Π΅ Π½Π°Π΄ ΠΏΡΠΎΠ±Π°ΠΌΠΈ Ρ Π±ΠΎΠ»ΡΡΠΈΠΌ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ΠΌ Π²ΠΎΠ΄Ρ (ΠΊΡΠΎΠ²Ρ, ΠΌΠΎΡΠ°, Π»ΠΈΠΌΡΠ°, ΠΏΠΎΡ, ΡΠΎΠΊΠΈ, Π½Π°ΠΏΠΈΡΠΊΠΈ)
Quantum dots: experience and prospects of application in analytical systems
Π‘ΡΠ°ΡΡΡ Π½ΠΎΡΠΈΡ ΠΎΠ±Π·ΠΎΡΠ½ΡΠΉ Ρ
Π°ΡΠ°ΠΊΡΠ΅Ρ, Π² Π½Π΅ΠΉ Π°Π½Π°Π»ΠΈΠ·ΠΈΡΡΠ΅ΡΡΡ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ° ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ, ΠΎΡΠ΅Π½ΠΈΠ²Π°ΡΡΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΠ²Π°Π½ΡΠΎΠ²ΡΡ
ΡΠΎΡΠ΅ΠΊ Π΄Π»Ρ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π·Π°Π΄Π°Ρ. ΠΡΠΈ ΡΡΠΎΠΌ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΡΠ΄Π΅Π»ΡΠ΅ΡΡΡ ΠΊΠ°ΠΊ ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΡΠΌ, ΡΠ°ΠΊ ΠΈ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠ΅Π΄ΠΊΠΈΠΌ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡΠΌ Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΡΠΈΡ
Π½Π°Π½ΠΎΡΡΡΡΠΊΡΡΡ. ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ ΠΊΡΠ°ΡΠΊΠΈΠΉ ΠΎΠ±Π·ΠΎΡ ΡΠΈΠΏΠΎΠ², Π΄ΠΎΡΡΠΎΠΈΠ½ΡΡΠ² ΠΈ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΊΠΎΠ² ΡΠΏΠΎΡΠΎΠ±ΠΎΠ² ΡΠΈΠ½ΡΠ΅Π·Π°, Π²Π»ΠΈΡΠ½ΠΈΡ Π²Π½Π΅ΡΠ½ΠΈΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² Π½Π° ΡΠΈΡΠΈΠ½Ρ Π·Π°ΠΏΡΠ΅ΡΠ΅Π½Π½ΠΎΠΉ Π·ΠΎΠ½Ρ ΠΈ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΡ Π»ΡΠΌΠΈΠ½Π΅ΡΡΠ΅Π½ΡΠΈΠΈ Π½Π΅ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
Π½Π°Π½ΠΎΡΠ°Π·ΠΌΠ΅ΡΠ½ΡΡ
Π»ΡΠΌΠΈΠ½ΠΎΡΠΎΡΠΎΠ² - ΠΊΠ²Π°Π½ΡΠΎΠ²ΡΡ
ΡΠΎΡΠ΅ΠΊ ΡΠ°Π·Π½ΠΎΠΉ ΠΏΡΠΈΡΠΎΠ΄Ρ. Π‘ΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΠΎΠ±Π»Π°ΡΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΈ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ Π·Π°Π΄Π°ΡΠΈ, ΡΠ΅ΡΠ°Π΅ΠΌΡΠ΅ Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΠΊΠ²Π°Π½ΡΠΎΠ²ΡΡ
ΡΠΎΡΠ΅ΠΊ. ΠΠ±ΡΡΠΆΠ΄Π°ΡΡΡΡ ΠΈΡ
Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ, ΡΠΊΡΠΏΠ»ΡΠ°ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΠΈ ΡΠΏΠΎΡΠΎΠ±Ρ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΈΠΌΠΈ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ ΡΠΏΠΎΡΠΎΠ±ΠΎΠΌ ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΡ Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌΠΈ ΡΠΈΡΡΠ΅ΠΌ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΊΠ²Π°Π½ΡΠΎΠ²ΡΡ
ΡΠΎΡΠ΅ΠΊ ΡΠ²Π»ΡΠ΅ΡΡΡ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΠΎΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΡΡΠΎΠ΄ΡΡΠ²Π° ΠΊ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ°ΠΌ Π·Π° ΡΡΠ΅Ρ Π²Π°ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΈΡΠΎΠ΄Ρ ΡΡΠ°Π±ΠΈΠ»ΠΈΠ·ΠΈΡΡΡΡΠ΅ΠΉ ΠΈΠ»ΠΈ ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΡΡΡΠ΅ΠΉ ΠΎΠ±ΠΎΠ»ΠΎΡΠΊΠΈ. ΠΠ»Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Π² Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅Π»ΡΡ
Π²ΡΠ΄Π΅Π»Π΅Π½Ρ ΠΏΠΎΠ»ΡΠΏΡΠΎΠ²ΠΎΠ΄Π½ΠΈΠΊΠΎΠ²ΡΠ΅ ΠΊΠΎΠ»Π»ΠΎΠΈΠ΄Π½ΡΠ΅ ΠΊΠ²Π°Π½ΡΠΎΠ²ΡΠ΅ ΡΠΎΡΠΊΠΈ, ΠΏΠΎΠΊΡΡΡΡΠ΅ ΠΎΠ±ΠΎΠ»ΠΎΡΠΊΠΎΠΉ Ρ Π±ΠΎΠ»ΡΡΠ΅ΠΉ ΡΠΈΡΠΈΠ½ΠΎΠΉ Π·Π°ΠΏΡΠ΅ΡΠ΅Π½Π½ΠΎΠΉ Π·ΠΎΠ½Ρ, ΠΊΠ°ΠΊ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΡΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΠ΅ ΡΠΈΡΡΠ΅ΠΌΡ, Π±Π»Π°Π³ΠΎΠ΄Π°ΡΡ ΠΈΡ
Ρ
ΠΎΡΠΎΡΠΈΠΌ ΡΠΎΡΠΎΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ ΠΈ ΠΊΠ²Π°Π½ΡΠΎΠ²ΠΎΠΌΡ Π²ΡΡ
ΠΎΠ΄Ρ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠΈΠΈ. ΠΠΎΠΊΠ°Π·Π°Π½Ρ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π° ΠΈ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΊΠΈ Π΄ΡΡΠ³ΠΈΡ
ΡΠΈΠΏΠΎΠ² ΠΎΠ±ΠΎΠ»ΠΎΡΠ΅ΠΊ, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠΏΠΎΡΠΎΠ±Ρ ΠΈΡ
ΠΌΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ. Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΡΠ΅ΡΠ΅Π½ΠΈΡ Π΄Π»Ρ ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΠΈ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ. Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΡΠΈΡΡΠ΅ΠΌΡ ΠΊΠ²Π°Π½ΡΠΎΠ²ΡΡ
ΡΠΎΡΠ΅ΠΊ, ΠΏΡΠΈΠΌΠ΅Π½ΡΠ΅ΠΌΡΠ΅ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ Π±ΠΈΠΎΡΠ΅Π½ΡΠΎΡΠΎΠ², Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌΠΈ Π½Π°ΠΏΡΠ°Π²Π»ΡΡΡΠΈΠΌΠΈ Π°Π³Π΅Π½ΡΠ°ΠΌΠΈ, ΡΠΎΠΏΠΎΡΡΠ°Π²Π»Π΅Π½Ρ ΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ²Π°, Π΄ΠΎΡΡΠΎΠΈΠ½ΡΡΠ²Π° ΠΈ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΊΠΈ. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ ΠΌΠ°Π»ΠΎ ΠΏΡΠΎΡΠ°Π±ΠΎΡΠ°Π½Π½ΡΠ΅ Π²ΠΎΠΏΡΠΎΡΡ ΠΈ ΡΠ΅ΡΠ΅Π½ΠΈΡ Π² Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΠ²Π°Π½ΡΠΎΠ²ΡΡ
ΡΠΎΡΠ΅ΠΊ Π΄Π»Ρ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ ΡΠ΅Π½ΡΠΎΡΠ½ΡΡ
ΡΠΈΡΡΠ΅ΠΌ, ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΈΡ
Π΄Π»Ρ Π½Π΅ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΠΆΠΈΠ²ΡΡ
ΡΠΈΡΡΠ΅ΠΌ ΠΏΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ Π΄Π΅ΡΠ΅ΠΊΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π»Π΅Π³ΠΊΠΎ Π»Π΅ΡΡΡΠΈΡ
ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ.The article is of a review nature, in which the dynamics of publication activity is analyzed and the possibilities of using quantum dots to solve various analytical problems are evaluated. The attention is paid to both traditional and relatively rare areas of analytical application of these nanostructures. A brief review of the types, advantages and disadvantages of synthesis methods, the influence of external factors on the band gap and luminescence intensity of inorganic nanosized phosphors, quantum dots of different nature, is presented. The areas of application and the main tasks solved with the use of quantum dots are systematized. Their analytical characteristics, operational properties and ways of regulating them are discussed. An effective way to control the analytical properties of the systems based on quantum dots is a directional change of the affinity for components by varying the nature of the stabilizing or modifying shell. Semiconductor colloidal quantum dots coated with a larger bandgap shell were selected for analytical use as the most commonly used systems due to their good photostability and fluorescence quantum yield. The advantages and disadvantages of other types of shells, as well as ways of modifying them, are shown. Solutions for organic analysis and medical diagnostics are considered. Systems of quantum dots used as biosensors with various guiding agents are considered, and their properties, advantages and disadvantages compared. Little studied issues and solutions in the direction of using quantum dots for developing sensor systems and their use for non-invasive analysis of living systems based on the results of detection of volatile organic compounds are identified.ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΎ Π·Π° ΡΡΠ΅Ρ Π³ΡΠ°Π½ΡΠ° Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠ³ΠΎ Π½Π°ΡΡΠ½ΠΎΠ³ΠΎ ΡΠΎΠ½Π΄Π° β 23-23-00609, https://rscf.ru/project/ 23-23-00609.This work was supported by the Russian Science Foundation (grant no. β 23-23-00609, https://rscf.ru/project/ 23-23-00609
Artificial smell sensor systems in the diagnostics of neurodegenerative diseases
ΠΠ΅ΠΉΡΠΎΠ΄Π΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠ²Π½ΡΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡ ΡΠΎΠ±ΠΎΠΉ Π³ΡΡΠΏΠΏΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Π½Π΅ΡΠ²Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ, ΠΊΠΎΡΠΎΡΡΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΡΡ ΠΌΠ½ΠΎΠ³ΠΎΠ»Π΅ΡΠ½Π΅ΠΉ Π»Π°ΡΠ΅Π½ΡΠ½ΠΎΠΉ ΡΡΠ°Π΄ΠΈΠ΅ΠΉ, ΠΌΠ½ΠΎΠ³ΠΎΠΎΠ±ΡΠ°Π·Π½ΠΎΡΡΡΡ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠΉ, ΡΠ²ΡΠ·Π°Π½Π½ΡΡ
Ρ Π½Π΅ΠΎΠ΄Π½ΠΎΡΠΎΠ΄Π½ΠΎΡΡΡΡ ΡΠΈΠΌΠΏΡΠΎΠΌΠΎΠ², ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠΉ Π°Π³ΡΠ΅ΡΡΠΈΠ²Π½ΠΎΡΡΡΡ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΈ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΡΡΡΠ΅ΠΉ Π³ΠΈΠ±Π΅Π»ΡΡ Π½Π΅ΠΉΡΠΎΠ½ΠΎΠ². ΠΠ΅ΠΉΡΠΎΠ΄Π΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠ²Π½ΡΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ Π² ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠΌ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΡΡΡΡΡ Π½Π° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
Π΄Π°Π½Π½ΡΡ
ΠΈ Π΄ΠΎΡΠΎΠ³ΠΎΡΡΠΎΡΡΠΈΡ
ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΡΡ
ΠΈ Π½Π΅ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π²ΠΈΠ·ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΠΎΠ³ΠΎ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΡΡΠ° Π΄Π»Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ Π½Π΅ΠΉΡΠΎΠ΄Π΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠ²Π½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Π½Π΅ ΡΡΡΠ΅ΡΡΠ²ΡΠ΅Ρ. ΠΡΠ΄ΡΡ
Π°Π΅ΠΌΡΠΉ Π²ΠΎΠ·Π΄ΡΡ
ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ΅ΠΊΡΠ΅ΡΠΈΠ΅ΠΉ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ°, ΠΈ ΠΏΡΠΎΡΠ΅ΡΡ Π΅Π³ΠΎ ΠΎΡΠ±ΠΎΡΠ° ΠΏΡΠΎΡΡ ΠΈ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅Π½. ΠΠ½Π°Π»ΠΈΠ· Π²ΡΠ΄ΡΡ
Π°Π΅ΠΌΠΎΠ³ΠΎ Π³Π°Π·Π° ΠΏΡΠ΅Π΄Π»Π°Π³Π°Π΅Ρ Π½Π΅Π΄ΠΎΡΠΎΠ³ΠΎΠΉ, Π½Π΅ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΡΠΉ ΠΌΠ΅ΡΠΎΠ΄ Π΄Π»Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π±ΠΎΠ»ΡΡΠΎΠ³ΠΎ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ Π½Π΅ΠΉΡΠΎΠ΄Π΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠ²Π½ΡΡ
. ΠΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠ΅ ΠΏΡΠΎΡΠΈΠ»ΠΈ Π»Π΅Π³ΠΊΠΎΠ»Π΅ΡΡΡΠΈΡ
ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ Π²ΡΠ΄ΡΡ
Π°Π΅ΠΌΠΎΠ³ΠΎ Π²ΠΎΠ·Π΄ΡΡ
Π° Π΄Π»Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΡΡΠ΄Π° Π½Π΅ΠΉΡΠΎΠ΄Π΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠ²Π½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΠΌΠΎΠΆΠ½ΠΎ ΠΏΠΎΠ»ΡΡΠΈΡΡ, Π°Π½Π°Π»ΠΈΠ·ΠΈΡΡΡ Π΄ΡΡ
Π°Π½ΠΈΠ΅ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Ρ ΠΏΠΎΠΌΠΎΡΡΡ Β«ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎΠ³ΠΎ Π½ΠΎΡΠ°Β». ΠΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ Π»Π΅Π³ΠΊΠΎΠ»Π΅ΡΡΡΠΈΡ
ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ ΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΈΡ
Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΡΡ
Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² Π½Π΅ΠΉΡΠΎΠ΄Π΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠ²Π½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Π΄Π»Ρ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΡΠΎΡΠ½ΠΎΠΉ, Π²ΠΎΡΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΠΌΠΎΠΉ ΠΈ Π±ΡΡΡΡΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΌΠΎΠΆΠ΅Ρ ΡΠ»ΡΠΆΠΈΡΡ Π°Π»ΡΡΠ΅ΡΠ½Π°ΡΠΈΠ²ΠΎΠΉ ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΡΠΌ ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌ. ΠΠ±Π·ΠΎΡ ΠΏΠΎΡΠ²ΡΡΠ΅Π½ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ°ΠΌ ΠΈ Π΄ΠΎΡΡΠΈΠΆΠ΅Π½ΠΈΡΠΌ ΠΏΠΎΡΠ»Π΅Π΄Π½Π΅Π³ΠΎ Π΄Π΅ΡΡΡΠΈΠ»Π΅ΡΠΈΡ (2014-2023 Π³Π³.) Π² ΡΡΠ΅ΡΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ Β«ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΡΠΉ Π½ΠΎΡΒ» Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΈ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ
Π»Π΅Π³ΠΊΠΎΠ»Π΅ΡΡΡΠΈΡ
ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ Π½Π΅ΠΉΡΠΎΠ΄Π΅Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠ²Π½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ². Π ΠΎΠ±Π·ΠΎΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΡ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ
Π»Π΅ΡΡΡΠΈΡ
ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ Π² Π²ΡΠ΄ΡΡ
Π°Π΅ΠΌΠΎΠΌ Π²ΠΎΠ·Π΄ΡΡ
Π΅ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π±ΠΎΠ»Π΅Π·Π½ΡΠΌΠΈ ΠΠ»ΡΡΠ³Π΅ΠΉΠΌΠ΅ΡΠ°, ΠΠ°ΡΠΊΠΈΠ½ΡΠΎΠ½Π°, ΡΠ°ΡΡΠ΅ΡΠ½Π½ΠΎΠ³ΠΎ ΡΠΊΠ»Π΅ΡΠΎΠ·Π°, Π±ΠΎΠΊΠΎΠ²ΠΎΠ³ΠΎ Π°ΠΌΠΈΠΎΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΊΠ»Π΅ΡΠΎΠ·Π° Ρ ΠΏΠΎΠΌΠΎΡΡΡ Β«ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎΠ³ΠΎ Π½ΠΎΡΠ°Β», Π³Π°Π·ΠΎΠ²ΠΎΠΉ Ρ
ΡΠΎΠΌΠ°ΡΠΎΠ³ΡΠ°ΡΠΈΠΈ-ΠΌΠ°ΡΡ-ΡΠΏΠ΅ΠΊΡΡΠΎΠΌΠ΅ΡΡΠΈΠΈ. ΠΠ±ΡΡΠΆΠ΄Π°ΡΡΡΡ ΡΠ΅Π½Π΄Π΅Π½ΡΠΈΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ Β«ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΡΠΉ Π½ΠΎΡΒ» Π΄Π»Ρ ΠΎΠΊΠ°Π·Π°Π½ΠΈΡ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΉ ΠΏΠΎΠΌΠΎΡΠΈ, ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΠΉ Π²ΡΠΏΠΎΠ»Π½ΡΡΡ ΡΠΎΡΠ½ΡΠ΅ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΊΠ»ΡΡΠ΅Π²ΡΡ
Π»Π΅ΡΡΡΠΈΡ
ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ Π² Π²ΡΠ΄ΡΡ
Π°Π΅ΠΌΠΎΠΌ Π²ΠΎΠ·Π΄ΡΡ
Π΅.Neurodegenerative diseases are a group of diseases of the nervous system that are characterized by a long-term latent stage, a variety of manifestations associated with heterogeneity of symptoms, different aggressiveness of the course, and progressive death of neurons. Neurodegenerative diseases are mainly diagnosed on the basis of clinical data and expensive invasive and non-invasive imaging techniques. There is no specific laboratory test for diagnosing neurodegenerative diseases. Exhaled air is the secretion of the body, and the process of its selection is simple and economical. Exhaled gas analysis offers an inexpensive, non-invasive method for detecting a wide range of diseases, including neurodegenerative ones. Molecular profiles of volatile organic compounds in exhaled air for the diagnosis of a number of neurodegenerative diseases can be obtained by analyzing human breath using an βelectronic noseβ. Identification of volatile organic compounds and their use as specific biomarkers of neurodegenerative diseases for obtaining accurate, reproducible and rapid diagnostics can serve as an alternative to traditional invasive methods. The review is devoted to the problems and achievements of the last decade (2014β2023) in the field of application of the "electronic nose" technology for determination and identification of potential highly volatile organic compounds of neurodegenerative processes. The review presents studies on the detection of potential volatile organic compounds in the exhaled air of patients with Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis using βelectronic noseβ, gas chromatography-mass spectrometry. Trends in the development and the use of "electronic nose" technology to provide medical care capable of performing accurate, sensitive determinations of key volatile organic compounds in the exhaled air are discussed
THE USE OF "ELECTRONIC SENSORS" IN ASSESSING THE FLAVOR OF BAKERY PRODUCTS FOR FUNCTIONAL PURPOSES
The percentage of the introduction of hemp flour into the formulation of bakery products for functional purposes through the use of "electronic sensors" for flavor research has been experimentally substantiated. Hemp flour has a pronounced color, taste and smell, which gives the composite mixtures a slightly herbaceous taste, while there is no unpleasant foreign smell