Evaluation of the effects of adhesion molecules and extracellular matrix proteins on biological behaviors of odontogenic lesions

Gerçek kistler vücudun diğer kemiklerine oranla çene kemiklerinde daha sık bulunur. Bu durum ağız dokularında kist oluşturabilecek çok sayıda odontojen epitel kalıntılarının varlığı ile açıklanabilir. Çoğu oldukça yavaş büyüme özelliği gösteren bu kistler, iltihapsal ve gelişimsel kistler olmak üzere iki ana sınıfa ayrılır. Bunların içinde gelişimsel bir kist olan odontojen keratokist (OKK) yerel nüks oranının yüksek oluşu ve agresif klinik davranışı nedeniyle diğer ağız kistlerinden ayrılmaktadır. Bu özellikler ağızda en çok görülen benign bir odontojen tümör olan ameloblastomun klinik seyri ile benzeşmektedir. Çalışmamızda parakeratotik odontojen kist (pOKK), ameloblastom ve dentigeröz kistlerin (DK) yerel yinelemelesi ve lokal agresif davranışlarıyla; ekstraselüler matriks proteinleri ve adezyon molekülleri arasındaki ilişki değerlendirildi. Değerlendirme ekstraselüler matriks proteinlerinden laminin ve kollagen; adezyon moleküllerinden ise E- kadherin, β -catenin ve ICAM antikorları ile yapıldı. DK' ların tüm boyamalarda pOKK ve Ameloblastoma göre istatistiksel olarak anlamlı derecede güçlü boyandığı tespit edildi. Sonuç olarak; pOKK ve ameloblastomun DK' dan az boyanmaları, yüksek yerel yineleme ve lokal agresif davranışlara sahip olması ile ilişkili olduğunu düşündürmektedir.True cysts are mostly found in jaw bones in proportion to other bones of the body. This may be explained by the presence of many odontogenic epithelial remnants in the oral tissues which could be the source of cysts. These cysts are classified into two main categories; developmental and inflammatory cysts. Many of these cysts have shown slow growing characteristics. Because of high local recurrence rate and aggressive clinical behavior of odontogenic keratocyst (OKC), which is a kind of developmental cyst, differs from the other cysts, particularly inflammatory cysts. These clinical features resemble the clinical features of ameloblastoma which is most common benign tumour of the oral tissue. In this study, relationship between recurrence and local aggresive behavior of parakeratotic odontogenic cyst (pOKC), ameloblastoma as well as dentigerous cyst (DK) and extracellular matrix proteins, adhesion molecules were evaluated. Laminin, kollagen IV, E- kadherin, β - catenin and ICAM anticors were used for assesment. DK were stained statistically significant more than ameloblastoma and pOKC for all anticors. As a conclussion, pOKC and ameloblastoma were stained lower than DK. This may be related to high recurrence and local agressive behavior of these lesions

Changes in the temporomandibular joint disc and temporal and masseter muscles secondary to bruxism in Turkish patients

WOS: 000425260400012PubMed ID: 29332113Objectives: To analyze the relationships between temporalis and masseter muscle hypertrophy and temporomandibular joint (TMJ) disc displacement in patients with severe bruxism using magnetic resonance imaging (MRI). Methods: This retrospective study included 100 patients with severe bruxism, referred to the Department of Oral and Maxillofacial Surgery, University of Marmara and Istanbul Medipol University, Istanbul, Turkey, between January 2015 and December 2016. Patients underwent TMJ MRI with a 1.5-T system in open and closed mouth positions. The masseter and temporalis muscles were measured in the axial plane when the patient's mouth was closed. Results: At its thinnest, the disc averaged was 1.11 +/- 0.24 mm. At their thickest, the masseter averaged was 13.65 +/- 2.19 mm and temporalis muscles was 12.98 +/- 2.4 mm. Of the discs, 24% were positioned normally, 74% were positioned anteriorly, and 2% were positioned posteriorly. The temporalis muscle was significantly thicker in patients with normally positioned discs than in those with anteriorly positioned discs (p=0.035). Conclusions: The temporalis muscle was significantly thicker in patients with normally positioned discs than in those with anteriorly positioned discs (p=0.035). Additional studies should be conducted to evaluate the relationships between all masticatory and surrounding muscles and disc movements in patients with bruxism

Comparison of alveolar ridge splitting and autogenous onlay bone grafting to enable implant placement in patients with atrophic jaw bones

WOS: 000417040800006PubMed ID: 29209669Objective: To compare alveolar ridge splitting (ARS) and autogenous onlay bone grafting (AOBG) in atrophic jaw bones. Methods: Forty patients were included in this retrospective, parallel-group study conducted at the Istanbul Medipol University School of Dentistry, Istanbul, Turkey, between 2012-2015. The initial bone thickness was measured by cone beam computed tomography (CBCT). Patients were allocated into ARS (n=17) and AOGB (n=23) groups on the basis of ridge thickness and shape. Follow-up CBCT measurements to assess horizontal bone were repeated 4 to 6 months post augmentation. The diameters of the implants were recorded. Implant bone resorption was measured at one year post implant placement on panoramic radiography. Surgical complications and implant survival were evaluated. Results: The final bone width in the AOBG group was significantly higher than that in the ARS group (p=0.029). Forty-four implants were inserted in the AOGB group, whereas 33 implants were inserted in the ARS group. There was no significant difference regarding implant diameter (p=0.920). Implant survival rate was 93.9% in the ARS group and 93.1% in the AOGB group. Peri-implant bone resorption at one year was higher in the AOBG group than in the ARS group (p=0.032). There were minor surgical complications, including bad split and wound dehiscence. Conclusion: The incidence of peri-implant bone resorption for the AOGB technique was higher than that for the ARS technique, but their implant survival rates were similar

Is 2 mm a safe distance from the inferior alveolar canal to avoid neurosensory complications in implant surgery?

Aim: The aim of the present study was to compare the neurosensory complications related to implants inserted closer than 2 mm to the inferior alveolar canal (IAC) with those inserted further than 2 mm. Materials and Methods: A total of 474 implants in 314 patients placed posterior to mental foramen area were evaluated retrospectively on panoramic radiographs. Patients were divided into two groups regarding implant proximity to the IAC (Group 1, distance ?2 mm, Group 2, distance >2 mm). Postoperative neurosensory complications (pain and paresthesia) were recorded. Chi-square test was used for statistical comparison and P ? 0.05 was considered significant. Results: One hundred and fifty-three implants (32.2%) were inserted closer than 2 mm to the IAC whereas 321 implants (67.8%) were inserted further than 2 mm. Three implants which had a distance of 0 mm to the IAC (0.63%) caused paresthesia after surgery. Implant distance to IAC did not show a significant difference regarding pain and paresthesia (P = 0.06 and P = 0.08, respectively). Conclusion: When 2 mm is considered as a safety distance, the distance of the implants to the IAC did not yield any statistical difference regarding postoperative neurosensory complications

How long do oral and maxillofacial surgery patients talk in first examination?

Amaç: Hastaların ilk muayene sırasında sözleri kesilmeden şikayetlerini aktarma süreleri tıbbın belli alanlarında incelenmiştir ancak bu konuda Ağız Diş ve Çene Cerrahisi bölümünde yapılmış bir araştırma bulunmamaktadır. Bu çalışmanın amacı Ağız, Diş ve Çene Cerrahisi kliniklerine ilk defa başvuran hastaların total konuşma zamanlarının değerlendirilmesidir. Gereç ve Yöntem: Çalışmaya 400 hasta dahil edilmiştir. Hastalar şikayetlerine göre; dentoalveolar cerrahi, temporomandibular eklem, dental implant, oral patoloji, dentofasiyal deformite ve travma olmak üzere 6 gruba ayrılmıştır. Bulgular: Çalışma sonucunda hastaların ortalama konuşma zamanının 27.6 saniye olduğu tespit edilmiştir. En uzun konuşma zamanı 42.3 sn (TME grup), en kısa konuşma zamanı ise 13.5 sn (travma grup) olarak ölçülmüştür. Yaş, cinsiyet ve ortalama konuşma zamanı arasında istatistiksel olarak anlamlı bir fark gözlenmemiştir. Sonuç: Daha ayrıntılı bilgi alabilmek ve hasta memnuniyetini arttırmak için; hastalar şikayetlerini anlatırken sözleri kesilmeden sonuna kadar dinlenmelidir.How long do oral and maxillofacial surgery patients talk in first examination? Öz (İngilizce):Introduction: Talking time of the patient without interruption during initial examination was evaluated in a few specialties but unknown in Oral and Maxillofacial Surgery (OMS) clinics. The aim of this study is to evaluate total talking time of the OMS patient in their first visit. Material and Methods: Four hundred patients were included in this study. The patients were analyzed in five groups; dentoalveolar, TMJ, pathology, dental implants and trauma. Results: The mean talking time of the patients was 27.6 seconds. The longest talking time was 42,3 seconds (TMJ patients) and the shortest time was 13,5 seconds (Trauma). There was no significant relation between age, sex and mean talking time. Conclusion: Clinicians should let the patient talk without interruption in order to get detailed information and possibly improve patient satisfaction