Effect of Biostimulants on Yield and Quality in Tomato

An experiment was conducted to study comparative efficacy of growth regulators and panchakavya on growth, yield and biochemical constitution of tomato. It is well known that panchakavya plays a vital role in organic cultivation. Hence, the present experiment was laid out to determine the effect of this biostimulant on yield and quality in tomato. Recommended dose of fertilizers recorded highest yield. Next best results were obtained by combined spray of panchakavya (3%) + salicylic acid (100ppm) + nitrobenzene (150ppm); panchakavya (3%) alone and panchakavya (3%) + salicylic acid (100ppm). Results also revealed comparable performance of panchakavya over salicylic acid and nitrobenzene indicating, that, panchakavya can be utilized as an organic component to increase yield in tomato

DEVELOPMENT OF RIVASTIGMINE LOADED SELF ASSEMBLED NANOSTRUCTURES OF NONIONIC SURFACTANTS FOR BRAIN DELIVERY

Objective: Aim of the study is to develop rivastigmine-loaded niosomal in situ gel via the intranasal route to the brain by crossing the Blood-Brain Barrier. For the treatment of Alzheimer’s disease, it provides a speedy onset of action, a faster therapeutic effect, avoidance of the first-pass metabolism, and enhanced bioavailability. Methods: Rivastigmine niosomal in situ nasal gel was developed, refined and tested with the goal of delivering the medicine to the brain via the intranasal route Rivastigmine niosomes were formulated by thin-film hydration technique, optimized using (32) factorial design and characterized for its physicochemical parameters. Rivastigmine-loaded niosomes were further incorporated into Carbopal-934P and HPMC-K4M liquid gelling system to form in situ nasal gel. The resulting solution was evaluated for several parameters including, viscosity at pH 5 and pH 6, gelling capacity and gelling time. Results: Optimized best formulation containing span 60 (A) and cholesterol (B) with (1:0.5) ratio identified from the model developed from Design-Expert®12 software, exhibited Entrapment efficiency (76.5±0.23%), particle size (933.4±0.14 nm), in vitro drug release maximum (68.94±0.26%) at 8th hour and further studied for its characteristics by SEM and TEM showed stable vesicles. Polynomial equations of Y1, Y2, and Y3 were conducted and ANOVA results showed a significant impact (p<0.05) on three levels. In vivo perfusion studies using rat model showed, the niosomes developed has good perfusion compared to pure drug with 27.2% of drug absorption in the brain at the end of 3 h. In vitro permeation of Rivastigmine through the dialysis membrane showed that 60.74% w/w drug permeated after 8 h. The formation of stable vesicles was proved by Zeta potential measurements and SEM analysis. Conclusion: Optimized formulation had greater perfusion and was expected to have a good bioavailability compared to conventional other drug delivery systems

Response of growth, yield and quality of small onion (Allium cepa L. var. aggregatum don.) to Tamil Nadu Agricultural University-Water Soluble Fertilizers (TNAU-WSF)

Enhancing the food production for the growing world population has needed application of highly sustainable and efficient inputs to produce more food per unit of land. Hence, Tamil Nadu Agricultural University (TNAU), Coimbatore, Tamil Nadu has produced Water soluble fertilizers (WSF) in its maiden attempt and it is necessary to optimize on different crops. Small onion is one of the most important vegetables in the Indian diet and it has high demand but low productivity. To enhance crop productivity and quality of small onions, the application of TNAU-WSF was taken up. A field experiment was laid out in a Randomized block design (RBD) incorporating 8 treatments comprising of application of RDF at100% NPK as TNAU WSF, soil test based application of 75%, 100%, 125% NPK ha-1 as TNAU-WSF with soil application of sulphur (S) and foliar spray of TNAU Liquid multi micronutrient (LMM) and without S and TNAU LMM and absolute control. Each treatment was replicated thrice with onion (CO 4). Soil test based application of 125% NPK ha-1 as TNAU-WSF with sulphur (S) and TNAU LMM recorded significantly higher in plant height (54.01 cm), the number of leaves per bulb (8.56), leaf greenness (67.5 SPAD), root length (5.42 cm), polar bulb diameter (4.38 cm), equatorial bulb diameter (2.72 cm) fresh bulb weight (74.21 g), bulb yield (1751 t ha-1) and quality attributes like total soluble solids (TSS) (14.78 °Brix), ascorbic acid content (15.34 mg 100 g-1), pyruvic acid content (2.27 µmol g-1). However, soil test based application of 100% NPK ha-1 as TNAU-WSF was found to be an ideal rate to attain the economic target yield of the onion crop

NIOSOMES AS AN EMERGING FORMULATION TOOL FOR DRUG DELIVERY-A REVIEW

Nonionic surfactant based vesicles which are uni/multilamellar in structures are called niosomes. These vesicles contains an aqueous interior surrounded by one or more amphiphilic bilayer membrane forming surfactant which separates them from the bulk solution, and are also called as supramolecular aggregates. Niosomes, being an efficient drug delivery system, investigations are carried out to utilize this system to treat various disorders, to promote improved patient compliance, lesser side effects, reduction in dose, lesser dosage frequency, and higher amount of the drug at the particular site so as to lessen an excessive contact with the whole body. The Pharmacokinetic and Pharmacodynamic profile of Niosomal drug delivery system vary for various entrapped drugs. Drugs that are successful in the mitigation or treatment of CNS disorders should cross the BBB to reach the brain, as BBB seems to be an obstacle for a large number of drugs, including CNS active drugs. This article compiles recent techniques for the preparation and characterization of niosomes, the effect of formulation variables on its physicochemical properties and discussed about its effective applications in drug delivery

Influence of zeolite on heavy metal immobilization in municipal solid waste compost contaminated soil

The application of Municipal solid waste as compost (MSWC) in agricultural fields has become one of the most common practices. Besides its benefits, it poses some harmful effects on soil, as it increases the heavy metal content in MSWC of the soil. It is necessary to find a way to reduce the bioavailability of heavy metals in MSWC  before its application into the soil. This study aimed at exploring the efficiency of zeolite as an immobilizer to dwindle heavy metal bioavailability. An incubation experiment was conducted wherein the soil samples were artificially spiked with different rates of MSWC (0, 5, and 10 t ha-1). The zeolite was added to the spiked soil at 5 different levels, namely 0, 5, 10, 15, and 20 %, and their effect on bioavailable heavy metal status was observed during different incubation intervals (0, 15. 30, 60, 90, and 120 days). Results unveiled that applying 10% zeolite significantly (P<0.05) reduced the bioavailability of lead (Pb) and nickel (Ni)  to Below the detectable limit (Bdl) in all soil samples. Furthermore, the organic carbon status of soil was also enriched by MSWC and 10% zeolite application. The soil pH slightly increased (7.39) with applying 10% zeolite resulting in the immobilization of heavy metals. Hence, 10% zeolite application was one of the most effective immobilizers in eliminating the bioavailability of heavy metals. Therefore, it can be concluded that mixing zeolite with MSWC before applying it to crop fields can reduce the heavy metal overload in soil. Hence, this study highlights the potential of zeolite as an effective choice in dwindling the soil's bioavailability of heavy metal content

The teacher as a research participant/consumer and researcher

The present article addresses the significance of the teacher as a researcher in her own right besides being a consumer of research information and a participant in other’s research. We will begin by looking at some of the reasons why people do research in Early Childhood Care and Education (ECCE). Whether done on a large scale or small scale research in ECCE serves several purposes

Artificial Intelligence in Human Resource Management: Advancements, Implications and Future Prospects

The present condition, challenges, and potential applications of artificial intelligence (AI) in human resource management (HRM) are all explored in this survey article. As an innovation, artificial intelligence (AI) has the potential to completely revolutionize several facets of human resource management (HRM). Examining the usage of AI-powered tools and systems in different HR processes, the present situation with AI in HRM is examined. These encompass learning and development, performance management, employee engagement, and recruiting. The use of AI algorithms and machine learning approaches to automate regular HR operations, analyze vast amounts of employee data, and provide insightful data to aid decision-making is addressed in this article. However, integrating AI into HRM also poses a number of difficulties that must be resolved. Bias, privacy issues, and transparency are just a few of the ethical and legal ramifications of using AI in decision-making processes that are discussed in this survey. The study emphasizes how accountability and fairness must be maintained in AI systems by responsible design, oversight, and periodic evaluation. With an emphasis on job displacement and workforce reorganization, the possible influence of AI on the human workforce is also explored. To effectively traverse this change, strategies including work role redefinition, employee up skilling, and establishing a collaborative atmosphere between humans and AI are suggested. The possible advantages and breakthroughs that AI might bring to HRM practices are highlighted as the future perspectives of AI in HRM are examined. As new applications for AI in HRM, sentiment analysis, predictive analytics, intelligent decision support, and personalized employee experiences are all highlighted. In order to fully realize the promise of AI in HRM, the study underlines the significance of data infrastructure, data governance frameworks, and a data-driven culture. Overall, this survey study offers an in-depth review of the existing situation, difficulties, and prospects for AI in HRM. It aggregates current information, identifies research gaps, and gives practitioners and scholars new perspectives on how AI will fundamentally alter the way HRM activities are carried out in the future

FORMULATION AND PHARMACOKINETIC DETERMINATION OF GALLIC ACID IN EMBLICA OFFICINALIS

Objective: The present work was to formulate oral herbal tablets of Emblica officinalis extract and also with pure gallic acid, further to determine the dosage frequency through pharmacokinetic profiles obtained for the same.Methods: The Emblica officinalis fruits were suitably extracted and the concentration of gallic acid in Emblica officinalis extract was estimated by HPTLC (High-Performance Thin Layer Chromatography) with a comparison to pure form. Tablets were prepared with extract and synthetic form through direct compression technique by varying the process and formulation parameters. The formulated tablets were administered to rabbit models and their pharmacokinetic profile was studied after withdrawing blood samples through HPLC (High-Performance Liquid Chromatography).Results: The concentration of gallic acid in Emblica officinalis was found to be 8.21%. The pre and post compression parameters evaluated for the formulated batches found to be within the pharmacopoeial limits. The in vivo pharmacokinetic studies conducted in rabbit models showed that there were no significant differences with p-value between the pharmacokinetic data obtained for pure and extract gallic acid tablets. The Cmax was found to be 4.59±0.95 µg/ml in the extract form which was little low when compared to the pure form of 6.38±1.08 µg/ml. The t1/2 in the extract form was 6.0±0.33 h, whereas it was 4.92±0.36 h in the pure form of gallic acid.Conclusion: The Emblica officinalis extract tablet showed average t1/2 of 6 h, so about every 6 h one tablet compared to 4 h of t1/2 for pure gallic acid tablet can be the dosing frequency for the rabbit.Â

Influence of potassium iodate and chitosan iodate complex on growth, yield, quality and iodine uptake in ‘shivam’ hybrid of tomato (Solanum lycopersicum L.)

An iodine biofortification experiment was conducted by applying potassium iodate fertilizer in soil and foliar form and chitosan complex forms to investigate the growth, yield, quality and uptake of iodine in shivam hybrid of tomato in Palaviduthi soil series of Coimbatore region. Soil fertilization alone resulted in lower uptake of iodine in fruits because the iodine is susceptible to high volatilization and less phytoavailability and also resulted in less yield and poor quality of fruits. When the chitosan and potassium iodate were applied in combination through foliar form, the quality of the fruits was found to be superior (carotene-1.24 mg 100gm-1 ascorbic acid- 3.56 mg 100gm-1, titrable acidity-0.96%), with higher fruit yield (94.81 t ha-1) and uptake of iodine in fruits (0.99ppm). Potassium iodate alone, either in the form of soil or foliar application, increased the quality of fruits, but it did not prevent the loss of various pigments and acids during ripening and also the loss of iodine through volatilization. But chitosan conserved the losses by reducing the respiration rate and oxygen permeability. Further, chitosan formed an electrostatic interaction with potassium iodate, preventing volatilisation and gradually increasing the bioavailability of iodine from soil to fruits. Hence biofortifying iodine in the form of potassium iodate chitosan complex was preferred for enhancing yield, improving quality and increasing the iodine content in fruits