The Guidebook, the Friend, and the Room: Visitor Experience in a Historic House

In this paper, we describe an electronic guidebook prototype and report on a study of its use in a historic house. Supported by mechanisms in the guidebook, visitors constructed experiences that had a high degree of interaction with three entities: the guidebook, their companions, and the house and its contents. For example, we found that most visitors played audio descriptions played through speakers (rather than using headphones or reading textual descriptions) to facilitate communication with their companions

Practical Strategies for Integrating a Conversation Analyst in an Iterative Design Process

We present a case study of an iterative design process that includes a conversation analyst. We discuss potential benefits of conversation analysis for design, and we describe our strategies for integrating the conversation analyst in the design process. Since the analyst on our team had no previous exposure to design or engineering, and none of the other members of our team had any experience with conversation analysis, we needed to build a foundation for our interaction. One of our key strategies was to pair the conversation analyst with a designer in a highly interactive collaboration. Our tactics have been effective on our project, leading to valuable results that we believe we could not have obtained using another method. We hope that this paper can serve as a practical guide to those interested in establishing a productive and efficient working relationship between a conversation analyst and the other members of a design team.Comment: 11 page

The tensor part of the Skyrme energy density functional. III. Time-odd terms at high spin

This article extends previous studies on the effect of tensor terms in the Skyrme energy density functional by breaking of time-reversal invariance. We have systematically probed the impact of tensor terms on properties of superdeformed rotational bands calculated within the cranked Hartree-Fock-Bogoliubov approach for different parameterizations covering a wide range of values for the isoscalar and isovector tensor coupling constants. We analyze in detail the contribution of the tensor terms to the energies and dynamical moments of inertia and study their impact on quasi-particle spectra. Special attention is devoted to the time-odd tensor terms, the effect of variations of their coupling constants and finite-size instabilities.Comment: 28 pages, 34 figure

Multivalent Probes in Molecular Imaging:Reality or Future?

The rapidly developing field of molecular medical imaging focuses on specific visualization of (patho)physiological processes through the application of imaging agents (IAs) in multiple clinical modalities. Although our understanding of the principles underlying efficient IAs design has increased tremendously, many IAs still show poor in vivo imaging performance because of low binding affinity and/or specificity. These limitations can be addressed by taking advantage of multivalency, in which multiple copies of a ligand are employed to strengthen the interaction. We critically address specific challenges associated with the application of multivalent compounds in molecular imaging, and we give directions for a stepwise approach to the design of multivalent imaging probes to improve their target binding and pharmacokinetics (PK) for improved diagnostic potential. The rapidly developing field of molecular medical imaging focuses on specific visualization of (patho)physiological processes through the application of imaging agents (IAs) in multiple clinical modalities. Although our understanding of the principles underlying efficient IAs design has increased tremendously, many IAs still show poor in vivo imaging performance because of low binding affinity and/or specificity. These limitations can be addressed by taking advantage of multivalency, in which multiple copies of a ligand are employed to strengthen the interaction. We critically address specific challenges associated with the application of multivalent compounds in molecular imaging, and we give directions for a stepwise approach to the design of multivalent imaging probes to improve their target binding and pharmacokinetics (PK) for improved diagnostic potential. Challenges and Applications of Molecular Imaging in Medicine Medical imaging enables the visualization of anatomical structures and physiological processes for diagnostic purposes [1,2], and is commonly subcategorized into structural, functional, and molecular imaging [3]. Molecular imaging reveals diagnostically relevant biochemical information [4,5] at cellular and molecular levels in vivo [6,7]. Therefore, in addition to diagnostic applications

An Investigation of Be/X-ray Pulsars with OGLE-III Data

We have studied five seasons of OGLE-III data for eight SMC Be/X-ray pulsars for which no other survey data were available. We have determined orbital periods for four of these binary systems, one of which also shows nonradial pulsations. Optical identification of SMC X-2 is reconsidered, but no periods were found for either of the two possible candidates

Photoresponsive molecular tools for emerging applications of light in medicine

Light-based therapeutic and imaging modalities, which emerge in clinical applications, rely on molecular tools, such as photocleavable protecting groups and photoswitches that respond to photonic stimulus and translate it into a biological effect. However, optimisation of their key parameters (activation wavelength, band separation, fatigue resistance and half-life) is necessary to enable application in the medical field. In this perspective, we describe the applications scenarios that can be envisioned in clinical practice and then we use those scenarios to explain the necessary properties that the photoresponsive tools used to control biological function should possess, highlighted by examples from medical imaging, drug delivery and photopharmacology. We then present how the (photo)chemical parameters are currently being optimized and an outlook is given on pharmacological aspects (toxicity, solubility, and stability) of light-responsive molecules. With these interdisciplinary insights, we aim to inspire the future directions for the development of photocontrolled tools that will empower clinical applications of light