Self-regulation to practice: Incorporating the strategy to an early childhood special education setting

Preschool students who display social emotional deficits pose challenging issues for families, caregivers and teachers who educate them. In this study, the effectiveness of an assistive technology based treatment package consisting of video self-modeling and behavior management software was investigated to determine if its combined use would result in increased student self-regulation skills. Using a multiple baseline design, three students used the treatment package to increase self-regulation skills. During the investigation, the accuracy to self-identify behaviors, the documentation of desired and undesired behaviors and the overall impact of the treatment package was studied. Interobserver agreement (IOA) was used to determine accuracy to self-identify behaviors. Results indicated a student increase in identifying undesired and desired behaviors, the percentage of desired behaviors displayed, and the accuracy with self-identifying behavior

The perception of affective and discriminative touch in blind individuals

Enhanced tactile acuity in blindness is among the most widely reported results of neuroplasticity following prolonged visual deprivation. However, tactile submodalities other than discriminative touch are profoundly understudied in blind individuals. Here, we examined the influence of blindness on two tactile submodalities, affective and discriminative touch, the former being vital for social functioning and emotional processing. We tested 36 blind individuals and 36 age- and sex-matched sighted volunteers. In Experiment 1, we measured the perception of affective tactile signals by asking participants to rate the pleasantness of touch delivered on the palm (nonhairy skin, sparsely innervated with C tactile [CT] fibers) or the forearm (hairy skin, densely innervated with CT fibers) in a CT-optimal versus a CT-nonoptimal manner using a paradigm grounded in studies on tactile sensory neurophysiology. In Experiment 2, we implemented a classic task assessing discriminative touch abilities, the grating orientation task. We found that blind individuals rated the touch as more pleasant when delivered on the palm than on the forearm, while the opposite pattern was observed for sighted participants, who rated stimulation on the forearm as more pleasant than stimulation on the palm. We also replicated the previous findings showing enhanced discriminative tactile acuity in blind individuals. Altogether, our results suggest that blind individuals might experience affective touch differently than sighted individuals, with relatively greater pleasantness perceived on the palm. These results provide a broader insight into somatosensory perception in blind individuals, for the first time taking into consideration the socioemotional aspect of touch

Blind individuals’ enhanced ability to sense their own heartbeat is related to the thickness of their occipital cortex

Blindness is associated with heightened sensory abilities, such as improved hearing and tactile acuity. Moreover, recent evidence suggests that blind individuals are better than sighted individuals at perceiving their own heartbeat, suggesting enhanced interoceptive accuracy. Structural changes in the occipital cortex have been hypothesized as the basis of these behavioral enhancements. Indeed, several studies have shown that congenitally blind individuals have increased cortical thickness within occipital areas compared to sighted individuals, but how these structural differences relate to behavioral enhancements is unclear. This study investigated the relationship between cardiac interoceptive accuracy and cortical thickness in 23 congenitally blind individuals and 23 matched sighted controls. Our results show a significant positive correlation between performance in a heartbeat counting task and cortical thickness only in the blind group, indicating a connection between structural changes in occipital areas and blind individuals’ better ability to perceive heartbeats

Fermi edge singularity in neutral electron-hole system

In neutral dense electron-hole (e-h) systems at low temperatures, theory predicts Cooper-pair-like excitons at the Fermi energy and a BCS-like exciton condensation. Optical excitation allows creating e-h systems with the densities controlled by the excitation power. However, the intense optical excitations required to achieve high densities cause substantial heating of the e-h system that prevents the realization of dense and cold e-h systems in conventional semiconductors. In this work, we study e-h systems created by optical excitation in separated electron and hole layers. The layer separation increases the e-h recombination time and, in turn, the density for a given optical excitation by orders of magnitude and, as a result, enables the realization of the dense and cold e-h system. We found a strong enhancement of photoluminescence intensity at the Fermi energy of the neutral dense ultracold e-h system that evidences the emergence of excitonic Fermi edge singularity due to the Cooper-pair-like excitons at the Fermi energy

Hyperon Polarization in the Constituent Quark Model

We consider mechanism for hyperon polarization in inclusive production. The main role belongs to the orbital angular momentum and polarization of the strange quark-antiquark pairs in the internal structure of the constituent quarks. We consider a nucleon as a core consisting of the constituent quarks embedded into quark condensate. The nonperturbative hadron structure is based on the results of chiral quark models.Comment: 14 pages, LaTeX, 2 Figures, References adde

Transverse Λ0\Lambda^0 polarization in inclusive quasi-real photoproduction at the current fragmentation

It is shown that the recent HERMES data on the transverse $\Lambda^0$ polarization in the inclusive quasi-real photoproduction at $x_F>0$ can be accommodated by the strange quark scattering model. Relations with the quark recombination approach are discussed.Comment: 5 pages, 3 figures, accepted by Eur. Phys. J.

Electrophysiological characterization of texture information slip-resistance dependent in the rat vibrissal nerve

<p>Abstract</p> <p>Background</p> <p>Studies in tactile discrimination agree that rats are able to learn a rough-smooth discrimination task by actively touching (whisking) objects with their vibrissae. In particular, we focus on recent evidence of how neurons at different levels of the sensory pathway carry information about tactile stimuli. Here, we analyzed the multifiber afferent discharge of one vibrissal nerve during active whisking. Vibrissae movements were induced by electrical stimulation of motor branches of the facial nerve. We used sandpapers of different grain size as roughness discrimination surfaces and we also consider the change of vibrissal slip-resistance as a way to improve tactile information acquisition. The amplitude of afferent activity was analyzed according to its Root Mean Square value (RMS). The comparisons among experimental situation were quantified by using the information theory.</p> <p>Results</p> <p>We found that the change of the vibrissal slip-resistance is a way to improve the roughness discrimination of surfaces. As roughness increased, the RMS values also increased in almost all cases. In addition, we observed a better discrimination performance in the retraction phase (maximum amount of information).</p> <p>Conclusions</p> <p>The evidence of amplitude changes due to roughness surfaces and slip-resistance levels allows to speculate that texture information is slip-resistance dependent at peripheral level.</p

Signatures of TOP1 transcription-associated mutagenesis in cancer and germline

The mutational landscape is shaped by many processes. Genic regions are vulnerable to mutation but are preferentially protected by transcription-coupled repair1. In microorganisms, transcription has been demonstrated to be mutagenic2,3; however, the impact of transcription-associated mutagenesis remains to be established in higher eukaryotes4. Here we show that ID4—a cancer insertion–deletion (indel) mutation signature of unknown aetiology5 characterized by short (2 to 5 base pair) deletions —is due to a transcription-associated mutagenesis process. We demonstrate that defective ribonucleotide excision repair in mammals is associated with the ID4 signature, with mutations occurring at a TNT sequence motif, implicating topoisomerase 1 (TOP1) activity at sites of genome-embedded ribonucleotides as a mechanistic basis. Such TOP1-mediated deletions occur somatically in cancer, and the ID-TOP1 signature is also found in physiological settings, contributing to genic de novo indel mutations in the germline. Thus, although topoisomerases protect against genome instability by relieving topological stress6, their activity may also be an important source of mutations in the human genome