Survival Motor Neuron (SMN) protein is required for normal mouse liver development

We would like to thank Lucas Fraga who helped with primer design and Alison Thomson for tissue collection. We would also like to acknowledge the Microscopy and Histology Core Facility at the University of Aberdeen for the use of their facilities. SHP is funded by Anatomical Society, Euan MacDonald Centre for Motor Neurone Disease Research and an Elphinstone Scholarship for ES from the University of Aberdeen. THG is funded by SMA Trust (UK SMA Research Consortium award), Muscular Dystrophy UK, and Anatomical Society (PhD Studentship). FM is funded by Medical Research Council, SMA-Europe and the National Institute for Health Research Biomedical Research Centre and Great Ormond Street Hospital Children’s Charity. HZ is funded by SMA-Europe and the National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children NHS Foundation Trust and University College London. Corrigendum: Survival Motor Neuron (SMN) protein is required for normal mouse liver development Published online: 10 November 2016 DOI: 10.1038/srep35898Peer reviewedPublisher PDFOthe

Systemic restoration of UBA1 ameliorates disease in spinal muscular atrophy

Acknowledgments Blood biochemistry analysis and serum analysis were performed by the Easter Bush Pathology Department, University of Edinburgh. Animal husbandry was performed by Centre for Integrative Physiology bio-research restructure technical staff, University of Edinburgh. Assistance with intravenous injections was provided by Ian Coldicott (University of Sheffield) and Hannah Shorrock (University of Edinburgh). Human blood cDNA was a gift to GH from Kathy Evans, University of Edinburgh. Imaging was performed at the IMPACT imaging facility, University of Edinburgh, with technical assistance from Anisha Kubasik-Thayil. The authors would also like to thank Lyndsay Murray for technical discussions relating to qRT-PCR analysis. This work was supported by funding from the SMA Trust and the Anatomical Society (via grants to THG); the Euan MacDonald Centre for Motor Neurone Disease Research (via grants to THG and SHP); the Wellcome Trust (via grants to EJNG and THG); Muscular Dystrophy UK (via grants to THG and CGB); a Elphinstone Scholarship from the University of Aberdeen (to SHP); and The French Muscular Dystrophy Association (via grants to CM and JC).Peer reviewedPublisher PD

Sexual health and human rights: protecting rights to promote health

Where sexual health refers to “a state of physical, mental, and social well-being in relation to sexuality,” human rights provide a path to realise the highest attainable standard of sexual health for all. Jonathan Mann first described the fundamental relationship between sexual health and human rights in the early years of the global AIDS response. He traced the arc between rights abuses and HIV transmission and provided a path to see sexual health and human rights as inextricably linked. The close interrelationships between sexual health and human rights led to the development of an evidence-based but rights-affirming approach to sexual health, abandoning coercive tools of public health, reducing stigma and discrimination toward key populations, and focusing on the social determinants of sexually transmitted infections (STI). Sexual health is thus seen as deeply embedded in the social and structural fabric of societies, with rights-based implications for epidemiology, intervention design, behavioral science, harm reduction, and laws and regulations governing health. Yet, many evidence-based STI interventions are unavailable because those at greatest risk hide their lives and sexual desires and practices from clinics and services. This BMC special collection focuses on the critical nexus of sexual health and human rights

Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022) statement: updated reporting guidance for health economic evaluations

Health economic evaluations are comparative analyses of alternative courses of action in terms of their costs and consequences. The Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement, published in 2013, was created to ensure health economic evaluations are identifiable, interpretable, and useful for decision making. It was intended as guidance to help authors report accurately which health interventions were being compared and in what context, how the evaluation was undertaken, what the findings were, and other details that may aid readers and reviewers in interpretation and use of the study. The new CHEERS 2022 statement replaces previous CHEERS reporting guidance. It reflects the need for guidance that can be more easily applied to all types of health economic evaluation, new methods and developments in the field, as well as the increased role of stakeholder involvement including patients and the public. It is also broadly applicable to any form of intervention intended to improve the health of individuals or the population, whether simple or complex, and without regard to context (such as health care, public health, education, social care, etc). This summary article presents the new CHEERS 2022 28-item checklist and recommendations for each item. The CHEERS 2022 statement is primarily intended for researchers reporting economic evaluations for peer reviewed journals as well as the peer reviewers and editors assessing them for publication. However, we anticipate familiarity with reporting requirements will be useful for analysts when planning studies. It may also be useful for health technology assessment bodies seeking guidance on reporting, as there is an increasing emphasis on transparency in decision making