225 research outputs found
From conformons to human brains: an informal overview of nonlinear dynamics and its applications in biomedicine
Methods of contemporary physics are increasingly important for biomedical research but, for a multitude of diverse reasons, most practitioners of biomedicine lack access to a comprehensive knowledge of these modern methodologies. This paper is an attempt to describe nonlinear dynamics and its methods in a way that could be read and understood by biomedical professionals who usually are not trained in advanced mathematics. After an overview of basic concepts and vocabulary of nonlinear dynamics, deterministic chaos, and fractals, application of nonlinear methods of biosignal analysis is discussed. In particular, five case studies are presented: 1. Monitoring the depth of anaesthesia and of sedation; 2. Bright Light Therapy and Seasonal Affective Disorder; 3. Analysis of posturographic signals; 4. Evoked EEG and photo-stimulation; 5. Influence of electromagnetic fields generated by cellular phones
Information storing by biomagnetites
Since the discovery of the presence of biogenic magnetites in living
organisms, there have been speculations on the role that these biomagnetites
play in cellular processes. It seems that the formation of biomagnetite
crystals is a universal phenomenon and not an exception in living cells. Many
experimental facts show that features of organic and inorganic processes could
be indistinguishable at nanoscale levels. Living cells are quantum "devices"
rather than simple electronic devices utilizing only the charge of conduction
electrons. In our opinion, due to their unusual biophysical properties, special
biomagnetites must have a biological function in living cells in general and in
the brain in particular. In this paper we advance a hypothesis that while
biomagnetites are developed jointly with organic molecules and cellular
electromagnetic fields in cells, they can record information about the Earth's
magnetic vector potential of the entire flight in migratory birds.Comment: 17 pages, 3 figure
The Fundamental Biological Activity of the Universe
If everything is in permanent change, can the Universe itself be fundamentally passive? Answering this question requires a clear concept of ‘activity.’ The nature of ‘action’ is a central and unsolved philosophical problem. Actions play a crucial role in the way we conceive of ourselves, life and the Universe, and the value we put on these. In four decades of research on solar activity, we found that activity is not a mere occurrence but a genuine activity of the Sun, initiated globally by the Sun using quantum processes as tools that generates suitable primary mass flows locally in the solar core that are capable of producing a working dynamo. We argue that solar activity is initiated by biological causes given by the fundamental principle of biology. This universal activity is the basis of our life instinct and of logic too
An integrated multidisciplinary model describing initiation of cancer and the Warburg hypothesis
Calcium regulation of muscle contraction.
Calcium triggers contraction by reaction with regulatory proteins that in the absence of calcium prevent interaction of actin and myosin. Two different regulatory systems are found in different muscles. In actin-linked regulation troponin and tropomyosin regulate actin by blocking sites on actin required for complex formation with myosin; in myosin-linked regulation sites on myosin are blocked in the absence of calcium. The major features of actin control are as follows: there is a requirement for tropomyosin and for a troponin complex having three different subunits with different functions; the actin displays a cooperative behavior; and a movement of tropomyosin occurs controlled by the calcium binding on troponin. Myosin regulation is controlled by a regulatory subunit that can be dissociated in scallop myosin reversibly by removing divalent cations with EDTA. Myosin control can function with pure actin in the absence of tropomyosin. Calcium binding and regulation of molluscan myosins depend on the presence of regulatory light chains. It is proposed that the light chains function by sterically blocking myosin sites in the absence of calcium, and that the "off" state of myosin requires cooperation between the two myosin heads. Both myosin control and actin control are widely distributed in different organisms. Many invertebrates have muscles with both types of regulation. Actin control is absent in the muscles of molluscs and in several minor phyla that lack troponin. Myosin control is not found in striated vertebrate muscles and in the fast muscles of crustacean decapods, although regulatory light chains are present. While in vivo myosin control may not be excluded from vertebrate striated muscles, myosin control may be absent as a result of mutations of the myosin heavy chain
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