Chlamydia pneumoniae in atherosclerotic middle cerebral artery

Background and Purpose—Atherosclerotic middle cerebral arteries are frequent sites of thrombosis, leading to stroke. Previous studies have suggested a role for Chlamydia pneumoniae in the pathogenesis of atherosclerosis. However, the presence of this pathogen in atherosclerotic middle cerebral arteries has heretofore not been documented. In the present study, we analyzed atheromatous plaques from middle cerebral arteries for the presence of C pneumoniae. Methods—Atherosclerotic middle cerebral arteries from 15 cadavers who died of natural causes and corresponding nonatherosclerotic arteries from 4 otherwise healthy trauma victims were examined. Assays for C pneumoniae DNA were carried out by nested polymerase chain reaction (nPCR) specific for the C pneumoniae ompA gene. The presence of the bacterium was assessed by transmission electron microscopy. Results—Five of the 15 atherosclerotic arterial samples and none of the control tissues were positive for C pneumoniae by nPCR. Particles similar in morphology and size to C pneumoniae elementary bodies were detected by transmission electron microscopy in 4 of the 5 nPCR-positive atherosclerotic samples. Conclusions—The demonstration of C pneumoniae in atherosclerotic middle cerebral arteries is consistent with the hypothesis that this bacterium is involved in acute and chronic cerebrovascular diseases

Improved survival of autologous stem cell transplantation in primary refractory and relapsed Hodgkin lymphoma in the brentuximab vedotin era - real-world data from Hungary

Autologous stem cell transplantation (ASCT) is the standard treatment of primary refractory or relapsed Hodgkin-lymphoma, which can provide a cure rate of about 50%. The aim of our study was to analyze the data of 126 HL patients undergoing AHSCT in Hungary between 01/01/2016 and 31/12/2020. We assessed the progression-free and overall survival, the prognostic role of PET/CT performed before transplantation and effect of brentuximab vedotin (BV) treatment on survival outcomes. The median follow-up time from AHSCT was 39 (1-76) months. The 5-year OS comparing PET- and PET + patients was 90% v. 74% (p = 0.039), and 5-year PFS was 74% v. 40% (p = 0.001). There was no difference in either OS or PFS compared to those who did not receive BV before AHSCT. We compared BV treatments based on their indication (BV only after AHSCT as maintenance therapy, BV before and after AHSCT as maintenance treatment, BV only before AHSCT, no BV treatment). There was statistically significant difference in the 5-year PFS based on the inication of BV therapy. Recovery rates of our R/R HL patient population, who underwent AHSCT, improved significantly. Our positive results can be attributed to the PET/CT directed, response-adapted treatment approach, and the widespread use of BV

Friedmann branes with variable tension

We introduce brane-worlds with non-constant tension, strenghtening the analogy with fluid membranes, which exhibit a temperature-dependence according to the empirical law established by E\"otv\"os. This new degree of freedom allows for evolving gravitational and cosmological constants, the latter being a natural candidate for dark energy. We establish the covariant dynamics on a brane with variable tension in full generality, by considering asymmetrically embedded branes and allowing for non-standard model fields in the 5-dimensional space-time. Then we apply the formalism for a perfect fluid on a Friedmann brane, which is embedded in a 5-dimensional charged Vaidya-Anti de Sitter space-time.Comment: 12 pages, to appear in Phys. Rev.

E\"otv\"os branes

The high value of brane tension has a crucial role in recovering Einstein's general relativity at low energies. In the framework of a recently developed formalism with variable brane tension one can pose the question, whether it was always that high? In analogy with fluid membranes, in this paper we allow for temperature dependent brane tension, according to the corresponding law established by E\"otv\"os. For cosmological branes this assumption leads to several immediate consequences: (a) The brane Universe was created at a finite temperature $T_{c}$ and scale factor $a_{\min}$. (b) Both the brane tension and the 4-dimensional gravitational coupling 'constant' increase with the scale factor from zero to asymptotic values. (c) The 4-dimensional cosmological 'constant' evolves with $a$, starting with a huge negative value, passing through zero, finally reaching a small positive value. Such a scale-factor dependent cosmological constant is able to generate a surplus of attraction at small $a$ (as dark matter does) and a late-time repulsion at large $a$ (dark energy). In the particular toy model discussed here the evolution of the brane tension is compensated by energy interchange between the brane and the fifth dimension, such that the continuity equation holds for the cosmological fluid. The resulting cosmology closely mimics the standard model at late times, a decelerated phase being followed by an accelerated expansion. The energy absorption of the brane drives the 5D space-time towards maximal symmetry, becoming Anti de Sitter.Comment: v2: 6 pages, 4 figures; expanded introduction and bibliography; published versio

Biomechanical Effects of Different Load Cases with an Implant-Supported Full Bridge on Four Implants in an Edentulous Mandible: A Three-Dimensional Finite Element Analysis (3D-FEA)

The long-term success and predictability of implant-supported restorations largely depends on the biomechanical forces (stresses) acting on implants and the surrounding alveolar bone in the mandible. The aim of our study was to investigate the biomechanical behavior of an edentulous mandible with an implant-supported full bridge on four implants under simulated masticatory forces, in the context of different loading schemes, using a three-dimensional finite element analysis (3D-FEA). A patient-specific 3D finite element model was constructed using pre- and post-implantation computer tomography (CT) images of a patient undergoing implant treatment. Simplified masticatory forces set at 300 N were exerted vertically on the denture in four different simulated load cases (LC1–LC4). Two sets of simulations for different implants and denture materials (S1: titanium and titanium; S2: titanium and cobalt-chromium, respectively) were made. Stress outputs were taken as maximum (Pmax) and minimum principal stress (Pmin) and equivalent stress (Peqv) values. The highest peak Pmax values were observed for LC2 (where the modelled masticatory force excluded the cantilevers of the denture extending behind the terminal implants), both regarding the cortical bone (S1 Pmax: 89.57 MPa, S2 Pmax: 102.98 MPa) and trabecular bone (S1 Pmax: 3.03 MPa, S2 Pmax: 2.62 MPa). Overall, LC1—where masticatory forces covered the entire mesio−distal surface of the denture, including the cantilever—was the most advantageous. Peak Pmax values in the cortical bone and the trabecular bone were 14.97–15.87% and 87.96–94.54% higher in the case of S2, respectively. To ensure the long-term maintenance and longevity of treatment for implant-supported restorations in the mandible, efforts to establish the stresses of the surrounding bone in the physiological range, with the most even stress distribution possible, have paramount importance