14 research outputs found
Generalized -conformal change and special Finsler spaces
In this paper, we investigate the change of Finslr metrics which we refer to as a
generalized -conformal change. Under this change, we study some special
Finsler spaces, namely, quasi C-reducible, semi C-reducible, C-reducible,
-like, -like and -like Finsler spaces. We also obtain the
transformation of the T-tensor under this change and study some interesting
special cases. We then impose a certain condition on the generalized
-conformal change, which we call the b-condition, and investigate the
geometric consequences of such condition. Finally, we give the conditions under
which a generalized -conformal change is projective and generalize some
known results in the literature.Comment: References added, some modifications are performed, LateX file, 24
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Inhibition or knock out of Inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury
BACKGROUND: In the present study, by comparing the responses in wild-type mice (WT) and mice lacking (KO) the inducible (or type 2) nitric oxide synthase (iNOS), we investigated the role played by iNOS in the development of on the lung injury caused by bleomycin administration. When compared to bleomycin-treated iNOSWT mice, iNOSKO mice, which had received bleomycin, exhibited a reduced degree of the (i) lost of body weight, (ii) mortality rate, (iii) infiltration of the lung with polymorphonuclear neutrophils (MPO activity), (iv) edema formation, (v) histological evidence of lung injury, (vi) lung collagen deposition and (vii) lung Transforming Growth Factor beta1 (TGF-β1) expression. METHODS: Mice subjected to intratracheal administration of bleomycin developed a significant lung injury. Immunohistochemical analysis for nitrotyrosine revealed a positive staining in lungs from bleomycin-treated iNOSWT mice. RESULTS: The intensity and degree of nitrotyrosine staining was markedly reduced in tissue section from bleomycin-iNOSKO mice. Treatment of iNOSWT mice with of GW274150, a novel, potent and selective inhibitor of iNOS activity (5 mg/kg i.p.) also significantly attenuated all of the above indicators of lung damage and inflammation. CONCLUSION: Taken together, our results clearly demonstrate that iNOS plays an important role in the lung injury induced by bleomycin in the mice