50 research outputs found
Additional file 1: of Impact of the condolence letter on the experience of bereaved families after a death in intensive care: study protocol for a randomized controlled trial
Family Information Letter. (DOCX 16 kb
Additional file 2: of Impact of the condolence letter on the experience of bereaved families after a death in intensive care: study protocol for a randomized controlled trial
Recommendations for writing a condolence letter and examples. (DOCX 22 kb
Correlation between clinical severity and different non-invasive measurements of carbon monoxide concentration: A population study
<div><p>Objectives</p><p>Carbon monoxide (CO) poisoning is a major concern in industrialized countries. Each year, thousands of victims, resulting in approximately 100 fatalities, are encountered in France. The diagnosis of CO poisoning is challenging; while carboxyhemoglobin (COHb) may be useful, it is a weak indicator of the severity of CO poisoning. This weak indicator may be a result of the delay between poisoning occurrence and the blood assay. Two apparatuses, CO oximeters and exhaled CO analyzers, now permit COHb to be determined outside hospitals. Our hypothesis is that these instruments allow the early measurement of COHb concentrations, which are more correlated with the severity of poisoning, expressed using the poisoning severity score (PSS).</p><p>Design</p><p>In an observational and retrospective cohort study, the distribution of COHb measurements obtained by CO oximetry or by exhaled CO analyzers was compared between groups of severity expressed using the PSS.</p><p>Setting</p><p>Data were collected in the Paris area from January 2006 to December 2010 by the French Surveillance System of CO poisoning.</p><p>Participants</p><p>All patients with CO poisoning reported to the French Surveillance System of CO poisoning.</p><p>Results</p><p>There was a significant difference in the COHb values obtained by CO oximetry between groups stratified according to PSS (p<0.0001). A significant difference in the values of exhaled CO was also observed between PSS groups (p = 0.006), although the relationship was not linear.</p><p>Conclusions</p><p>The COHb concentrations measured using CO oximetry, but not those measured using exhaled CO analyzers, were well correlated with the severity of CO poisoning.</p></div
Flow chart showing the types of assays performed.
<p>Flow chart showing the types of assays performed.</p
Relationship between exhaled CO (in ppm) and PSS.
<p>Relationship between exhaled CO (in ppm) and PSS.</p
Relationship between COHb measured by CO oximetry (in %) and PSS.
<p>Relationship between COHb measured by CO oximetry (in %) and PSS.</p
Relationship between COHb measurement by blood assay (in %) and PSS.
<p>Relationship between COHb measurement by blood assay (in %) and PSS.</p
Poisoning severity score (adapted from Persson et al. [9]).
<p>Poisoning severity score (adapted from Persson et al. [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0174672#pone.0174672.ref009" target="_blank">9</a>]).</p
Additional file 1: of Using Bayesian statistics to estimate the likelihood a new trial will demonstrate the efficacy of a new treatment
Bayesian Analyses. (DOCX 21Â kb
Flowchart.
<p>Combined regimen stands for <i>inopressors and inodilators</i>; *patients excluded for missing data concerning the treatment regimen, the outcome or the length of hospital stay; <sup>$</sup>patients included in the final analysis.</p