Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

BackgroundDisorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021.MethodsWe estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined.FindingsGlobally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378–521), affecting 3·40 billion (3·20–3·62) individuals (43·1%, 40·5–45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7–26·7) between 1990 and 2021. Age-standardised rates of deaths per 100 000 people attributed to these conditions decreased from 1990 to 2021 by 33·6% (27·6–38·8), and age-standardised rates of DALYs attributed to these conditions decreased by 27·0% (21·5–32·4). Age-standardised prevalence was almost stable, with a change of 1·5% (0·7–2·4). The ten conditions with the highest age-standardised DALYs in 2021 were stroke, neonatal encephalopathy, migraine, Alzheimer's disease and other dementias, diabetic neuropathy, meningitis, epilepsy, neurological complications due to preterm birth, autism spectrum disorder, and nervous system cancer.InterpretationAs the leading cause of overall disease burden in the world, with increasing global DALY counts, effective prevention, treatment, and rehabilitation strategies for disorders affecting the nervous system are needed

A novel deep neuroevolution-based image classification method to diagnose coronavirus disease (COVID-19)

COVID-19 has had a detrimental impact on normal activities, public safety, and the global financial system. To identify the presence of this disease within communities and to commence the management of infected patients early, positive cases should be diagnosed as quickly as possible. New results from X-ray imaging indicate that images provide key information about COVID-19. Advanced deep-learning (DL) models can be applied to X-ray radiological images to accurately diagnose this disease and to mitigate the effects of a shortage of skilled medical personnel in rural areas. However, the performance of DL models strongly depends on the methodology used to design their architectures. Therefore, deep neuroevolution (DNE) techniques are introduced to automatically design DL architectures accurately. In this paper, a new paradigm is proposed for the automated diagnosis of COVID-19 from chest X-ray images using a novel two-stage improved DNE Algorithm. The proposed DNE framework is evaluated on a real-world dataset and the results demonstrate that it provides the highest classification performance in terms of different evaluation metrics

Heat Transfer Studies on Solar Parabolic trough Collector Using Corrugated Tube Receiver with Conical Strip Inserts

The heat transfer characteristics of the working fluid passing through the absorber of a solar parabolic trough collector (SPTC) can be enhanced by the creation of a turbulence effect. Therefore, a novel idea was implemented by introducing a corrugated tube (CT) absorber instead of a plain tube absorber in a solar parabolic trough collector. The heat transfer enhancement was improved further through the use of conical strip inserts inside the corrugated tube absorber of the SPTC. A corrugated tube (CT) receiver with a pitch of 8 mm and corrugation height of 2 mm was used with three different pitches of conical strip inserts (pitch pi = 20 mm, 30 mm and 50 mm) for the analysis of the thermal performance of the SPTC. Initially, experiments were conducted in a plain tube and corrugated tube receiver at different mass flow rates. The convective heat transfer rate was increased for all the configurations of the conical strip inserts. The SPTC performance was good for the combination of the corrugated tube (pc = 8 mm and hc = 2 mm) and the conical strip insert I3 (pi= 20 mm). The experimental results showed that the maximum achieved Nu value, friction factor, instantaneous efficiency and thermal efficiency of the CT-I3 were 177%, 38%, 26.92% and 9% compared to the plain tube under the same working conditions

Attraction of Bus Rapid Transit (BRT) for Car and Bike Owners

This study aims to find the potential of Bus Rapid Transit (BRT) to attract the vehicle owners from their personal vehicles i.e., motorcars and motorcycles. Stated preference survey (questionnaires) and interviews were conducted at BRT (Metro Bus) Stations for the prediction of the individuals shifting from their private vehicles to BRT. Questions were designed critically as per the requirements of the research related to numerous aspects of BRT use i.e., vehicle ownership of the travelers, driving license holder, demographic characteristics, choice to use BRT if the fare increases, trip purpose and their prior mode of transportation for the same trip. A total of 374 responses, as per the population of the study area (Islamabad-Rawalpindi, Pakistan), were collected. The Multinomial Logistic Regression (MNL) model has been employed for four categories of vehicle ownerships i.e., “Car owners using BRT”, “Bike owners using BRT”, “Both Car and Bike owners using BRT” and the last one which has been taken as reference category is “BRT users with no vehicle ownership”. The analysis indicated that BRT has attracted considerably private vehicle users specially the bike owners. Some socio-economic factors like income and residence location (accessibility) additionally have a major effect on the selection of BRT. In addition, it has been observed that fare increase can alter the mode choice of the BRT users and they will again prefer their own vehicles. The Travel choice model developed in the study can be very useful for policy makers and transport planners to enhance the BRT service and attraction, to mitigate traffic congestion and car ownership

Solar irradiance forecasting using a novel hybrid deep ensemble reinforcement learning algorithm

Solar irradiance forecasting is a major priority for the power transmission systems in order to generate and incorporate the performance of massive photovoltaic plants efficiently. As such, prior forecasting techniques that use classical modelling and single deep learning models that undertake feature extraction procedures manually were unable to meet the output demands in specific situations with dynamic variability. Therefore, in this study, we propose an efficient novel hybrid solar irradiance forecasting model based on three steps. In the first step, we employ a powerful variable input selection strategy named as partial mutual information (PMI) to calculate the linear and non-linear correlations of the original solar irradiance data. In the second step, unlike the traditional deep learning models designing their architectures manually, we utilize several deep long short term memory-convolutional neural network (LSTM-CNN) models optimized by a novel modified whale optimization algorithm in order to compute the forecasting results of the solar irradiance datasets. Finally, in the third step, we deploy a deep reinforcement learning strategy for selecting the best subset of the combined deep optimized LSTM-CNN models. Through analysing the forecasting results over two real-world datasets gathered from the USA solar irradiance stations, it can be inferred that our proposed algorithm outperforms other powerful benchmarked algorithms in 1-step, 2-step, 12-step, and 24-step ahead forecasting.©2022 Elsevier. This manuscript version is made available under the Creative Commons Attribution–NonCommercial–NoDerivatives 4.0 International (CC BY–NC–ND 4.0) license, https://creativecommons.org/licenses/by-nc-nd/4.0/fi=vertaisarvioitu|en=peerReviewed

Solar irradiance forecasting using a novel hybrid deep ensemble reinforcement learning algorithm

Solar irradiance forecasting is a major priority for the power transmission systems in order to generate and incorporate the performance of massive photovoltaic plants efficiently. As such, prior forecasting techniques that use classical modelling and single deep learning models that undertake feature extraction procedures manually were unable to meet the output demands in specific situations with dynamic variability. Therefore, in this study, we propose an efficient novel hybrid solar irradiance forecasting model based on three steps. In the first step, we employ a powerful variable input selection strategy named as partial mutual information (PMI) to calculate the linear and non-linear correlations of the original solar irradiance data. In the second step, unlike the traditional deep learning models designing their architectures manually, we utilize several deep long short term memory-convolutional neural network (LSTM-CNN) models optimized by a novel modified whale optimization algorithm in order to compute the forecasting results of the solar irradiance datasets. Finally, in the third step, we deploy a deep reinforcement learning strategy for selecting the best subset of the combined deep optimized LSTM-CNN models. Through analysing the forecasting results over two real-world datasets gathered from the USA solar irradiance stations, it can be inferred that our proposed algorithm outperforms other powerful benchmarked algorithms in 1-step, 2-step, 12-step, and 24-step ahead forecasting

Wearable Flexible Electronics Based Cardiac Electrode for Researcher Mental Stress Detection System Using Machine Learning Models on Single Lead Electrocardiogram Signal

In the modern world, wearable smart devices are continuously used to monitor people’s health. This study aims to develop an automatic mental stress detection system for researchers based on Electrocardiogram (ECG) signals from smart T-shirts using machine learning classifiers. We used 20 subjects, including 10 from mental stress (after twelve hours of continuous work in the laboratory) and 10 from normal (after completing the sleep or without any work). We also applied three scoring techniques: Chalder Fatigue Scale (CFS), Specific Fatigue Scale (SFS), Depression, Anxiety, and Stress Scale (DASS), to confirm the mental stress. The total duration of ECG recording was 1800 min, including 1200 min during mental stress and 600 min during normal. We calculated two types of features, such as demographic and extracted by ECG signal. In addition, we used Decision Tree (DT), Naive Bayes (NB), Random Forest (RF), and Logistic Regression (LR) to classify the intra-subject (mental stress and normal) and inter-subject classification. The DT leave-one-out model has better performance in terms of recall (93.30%), specificity (96.70%), precision (94.40%), accuracy (93.30%), and F1 (93.50%) in the intra-subject classification. Additionally, The classification accuracy of the system in classifying inter-subjects is 94.10% when using a DT classifier. However, our findings suggest that the wearable smart T-shirt based on the DT classifier may be used in big data applications and health monitoring. Mental stress can lead to mitochondrial dysfunction, oxidative stress, blood pressure, cardiovascular disease, and various health problems. Therefore, real-time ECG signals help assess cardiovascular and related risk factors in the initial stage based on machine learning techniques

Annotation of Potential Vaccine Targets and Design of a Multi-Epitope Subunit Vaccine against <i>Yersinia pestis</i> through Reverse Vaccinology and Validation through an Agent-Based Modeling Approach

Yersinia pestis is responsible for plague and major pandemics in Asia and Europe. This bacterium has shown resistance to an array of drugs commonly used for the treatment of plague. Therefore, effective therapeutics measurements, such as designing a vaccine that can effectively and safely prevent Y. pestis infection, are of high interest. To fast-track vaccine development against Yersinia pestis, herein, proteome-wide vaccine target annotation was performed, and structural vaccinology-assisted epitopes were predicted. Among the total 3909 proteins, only 5 (rstB, YPO2385, hmuR, flaA1a, and psaB) were shortlisted as essential vaccine targets. These targets were then subjected to multi-epitope vaccine design using different linkers. EAAK, AAY, and GPGPG as linkers were used to link CTL, HTL, and B-cell epitopes, and an adjuvant (beta defensin) was also added at the N-terminal of the MEVC. Physiochemical characterization, such as determination of the instability index, theoretical pI, half-life, aliphatic index, stability profiling, antigenicity, allergenicity, and hydropathy of the ensemble, showed that the vaccine is highly stable, antigenic, and non-allergenic and produces multiple interactions with immune receptors upon docking. In addition, molecular dynamics simulation confirmed the stable binding and good dynamic properties of the vaccine–TLR complex. Furthermore, in silico and immune simulation of the developed MEVC for Y. pestis showed that the vaccine triggered strong immune response after several doses at different intervals. Neutralization of the antigen was observed at the third day of injection. Conclusively, the vaccine designed here for Y. pestis produces an immune response; however, further immunological testing is needed to unveil its real efficacy