Two sides of the same coin: The roles of KLF6 in physiology and pathophysiology

The Krüppel-like factors (KLFs) family of proteins control several key biological processes that include proliferation, differentiation, metabolism, apoptosis and inflammation. Dysregulation of KLF functions have been shown to disrupt cellular homeostasis and contribute to disease development. KLF6 is a relevant example; a range of functional and expression assays suggested that the dysregulation of KLF6 contributes to the onset of cancer, inflammation-associated diseases as well as cardiovascular diseases. KLF6 expression is either suppressed or elevated depending on the disease, and this is largely due to alternative splicing events producing KLF6 isoforms with specialised functions. Hence, the aim of this review is to discuss the known aspects of KLF6 biology that covers the gene and protein architecture, gene regulation, post-translational modifications and functions of KLF6 in health and diseases. We put special emphasis on the equivocal roles of its full-length and spliced variants. We also deliberate on the therapeutic strategies of KLF6 and its associated signalling pathways. Finally, we provide compelling basic and clinical questions to enhance the knowledge and research on elucidating the roles of KLF6 in physiological and pathophysiological processes. © 2020 by the authors. Licensee MDPI, Basel, Switzerland

Educational innovation for Industry 4.0: an exploration of integrated work-based learning's contribution

Purpose: The purpose of this research is to explore the role of integrated work-based learning in preparing students to meet the challenges of the Industry 4.0 work environment. It aims to investigate how incorporating work-based learning elements into the educational curriculum can enhance students' readiness for the dynamic and technology-driven landscape of Industry 4.0. Theoretical framework: This study is grounded in the theoretical framework of constructivism and experiential learning. Constructivism emphasizes active learning and the development of meaningful understanding through real-world experiences. Experiential learning theories, particularly Kolb's model, inform the research, highlighting the importance of concrete experiences, reflective observation, abstract conceptualization, and active experimentation in the learning process. Method/design/approach: A mixed-methods approach will be employed for this research. Quantitative data will be collected through surveys and assessments to measure the impact of integrated work-based learning on students' technical and soft skills. Qualitative data will be gathered through interviews and focus groups to explore students' perceptions and experiences. Results and conclusion: The results will provide insights into the effectiveness of integrated work-based learning in enhancing students' technical and soft skills. It will reveal the impact on their readiness for Industry 4.0 careers, as well as their ability to navigate the complexities of the modern workplace. Research implications: This research holds implications for educational institutions, policymakers, and industry stakeholders. It underscores the need to integrate work-based learning elements into curricula to better prepare students for Industry 4.0 careers. The findings will inform the development of strategies that enhance students' workforce readiness. Originality/value: This research contributes to the growing body of literature on work-based learning and its role in Industry 4.0 preparedness. It provides original insights into the effectiveness of integrated work-based learning programs, their impact on students, and their value in addressing the demands of the rapidly evolving work environment