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The detection and classification of blast cell in Leukaemia Acute Promyelocytic Leukaemia (AML M3) blood using simulated annealing and neural networks
This paper was delivered at AIME 2011: 13th Conference on Artifical Intelligence in Medicine.This paper presents a method for the detection and classification of blast cells in M3 with others sub-types using simulated annealing and neural networks. In this paper, we increased our test result from 10 images to 20 images. We performed Hill Climbing, Simulated Annealing and Genetic Algorithms for detecting the blast cells. As a result, simulated annealing is the “best” heuristic search for detecting the leukaemia cells. From the detection, we performed features extraction on the blast cells and we classifying based on M3 and other sub-types using neural networks. We received convincing result which has targeting around 97% in classifying of M3 with other sub-types. Our results are based on real world image data from a Haematology Department.Universiti Sains Islam Malaysia and the Ministry of Higher Education, Malaysi
Soft computing for intelligent data analysis
Intelligent data analysis (IDA) is an interdisciplinary study concerned with the effective analysis of data. The paper briefly looks at some of the key issues in intelligent data analysis, discusses the opportunities for soft computing in this context, and presents several IDA case studies in which soft computing has played key roles. These studies are all concerned with complex real-world problem solving, including consistency checking between mass spectral data with proposed chemical structures, screening for glaucoma and other eye diseases, forecasting of visual field deterioration, and diagnosis in an oil refinery involving multivariate time series. Bayesian networks, evolutionary computation, neural networks, and machine learning in general are some of those soft computing techniques effectively used in these studies
Distinguishing Motor Weakness From Impaired Spatial Awareness: A Helping Hand!
Our patient, aged 73 years, had background peripheral neuropathy of unknown cause, stable for several years, which caused some difficulty in walking on uneven ground. He attended for a teaching session but now staggered in, a new development. He had apparent weakness of his right arm, but there was difficulty in distinguishing motor weakness from impaired spatial awareness suggestive of parietal lobe dysfunction. With the patient seated, eyes closed, and left arm outstretched, S.A.R. lifted the patient’s right arm and asked him to indicate when both were level. This confirmed motor weakness. Urgent computed tomographic scan confirmed left subdural haematoma and its urgent evacuation rapidly resolved the patient’s symptoms. Intrigued by our patient’s case, we explored further and learnt that in rehabilitation medicine, the awareness of limb position is commonly viewed in terms of joint position sense. We present recent literature evidence indicating that the underlying mechanisms are more subtle
Scaling of the Random-Field Ising Model at Zero Temperature
The exact determination of ground states of small systems is used in a
scaling study of the random-field Ising model. While three variants of the
model are found to be in the same universality class in 3 dimensions, the
Gaussian and bimodal models behave distinctly in 4 dimensions with the latter
apparently having a discontinuous jump in the magnetization. A finite-size
scaling analysis is presented for this transition.Comment: 14 pages Latex, 4 figure
Shock and Release Temperatures in Molybdenum
Shock and release temperatures in Mo were calculated, taking account of
heating from plastic flow predicted using the Steinberg-Guinan model. Plastic
flow was calculated self-consistently with the shock jump conditions: this is
necessary for a rigorous estimate of the locus of shock states accessible. The
temperatures obtained were significantly higher than predicted assuming ideal
hydrodynamic loading. The temperatures were compared with surface emission
spectrometry measurements for Mo shocked to around 60GPa and then released into
vacuum or into a LiF window. Shock loading was induced by the impact of a
planar projectile, accelerated by high explosive or in a gas gun. Surface
velocimetry showed an elastic wave at the start of release from the shocked
state; the amplitude of the elastic wave matched the prediction to around 10%,
indicating that the predicted flow stress in the shocked state was reasonable.
The measured temperatures were consistent with the simulations, indicating that
the fraction of plastic work converted to heat was in the range 70-100% for
these loading conditions
Glassy behaviour in an exactly solved spin system with a ferromagnetic transition
We show that applying simple dynamical rules to Baxter's eight-vertex model
leads to a system which resembles a glass-forming liquid. There are analogies
with liquid, supercooled liquid, glassy and crystalline states. The disordered
phases exhibit strong dynamical heterogeneity at low temperatures, which may be
described in terms of an emergent mobility field. Their dynamics are
well-described by a simple model with trivial thermodynamics, but an emergent
kinetic constraint. We show that the (second order) thermodynamic transition to
the ordered phase may be interpreted in terms of confinement of the excitations
in the mobility field. We also describe the aging of disordered states towards
the ordered phase, in terms of simple rate equations.Comment: 11 page
Inelastic collapse of a randomly forced particle
We consider a randomly forced particle moving in a finite region, which
rebounds inelastically with coefficient of restitution r on collision with the
boundaries. We show that there is a transition at a critical value of r,
r_c\equiv e^{-\pi/\sqrt{3}}, above which the dynamics is ergodic but beneath
which the particle undergoes inelastic collapse, coming to rest after an
infinite number of collisions in a finite time. The value of r_c is argued to
be independent of the size of the region or the presence of a viscous damping
term in the equation of motion.Comment: 4 pages, REVTEX, 2 EPS figures, uses multicol.sty and epsf.st
Efficacy of qualitative response assessment interpretation criteria at 18F-FDG PET-CT for predicting outcome in locally advanced cervical carcinoma treated with chemoradiotherapy
Objectives: To evaluate the utility of a standardized qualitative scoring system for treatment response assessment at 18F-FDG PET-CT in patients undergoing chemoradiotherapy for locally advanced cervical carcinoma and correlate this with subsequent patient outcome. Methods: Ninety-six consecutive patients with locally advanced cervical carcinoma treated with radical chemoradiotherapy (CRT) in a single centre between 2011 and 2014 underwent 18F-FDG PET-CT approximately 3 months post-treatment. Tumour metabolic response was assessed qualitatively using a 5-point scale ranging from background level activity only through to progressive metabolic disease. Clinical and radiological (MRI pelvis) follow-up was performed in all patients. Progression-free (PFS) and overall survival (OS) was calculated using the Kaplan-Meier method (Mantel-Cox log-rank) and correlated with qualitative score using Chi-squared test. Results: Forty patients (41.7 %) demonstrated complete metabolic response (CMR) on post-treatment PET-CT (Score 1/2) with 38 patients (95.0 %) remaining disease free after a minimum follow-up period of 18 months. Twenty-four patients (25.0 %) had indeterminate residual uptake (ID, Score 3) at primary or nodal sites after treatment, of these eight patients (33.3 %) relapsed on follow-up, including all patients with residual nodal uptake (n = 4Eleven11 of 17 patients (64.7 %) with significant residual uptake (partial metabolic response, PMR, Score 4) subsequently relapsed. In 15 patients (15.6 %) PET-CT demonstrated progressive disease (PD, Score 5) following treatment. Kaplan-Meier analysis showed a highly statistically significant difference in PFS and OS between patients with CMR, indeterminate uptake, PMR and PD (Log-rank, P < 0.0001). Chi-squared test demonstrated a highly statistically significant association between increasing qualitative score and risk of recurrence or death (P < 0.001). Conclusion: Use of a 5-point qualitative scoring system to assess metabolic response to CRT in locally advanced cervical carcinoma predicts survival outcome and this prognostic information may help guide further patient management
M-Dwarf Fast Rotators and the Detection of Relatively Young Multiple M-Star Systems
We have searched the Kepler light curves of ~3900 M-star targets for evidence
of periodicities that indicate, by means of the effects of starspots, rapid
stellar rotation. Several analysis techniques, including Fourier transforms,
inspection of folded light curves, 'sonograms', and phase tracking of
individual modulation cycles, were applied in order to distinguish the
periodicities due to rapid rotation from those due to stellar pulsations,
eclipsing binaries, or transiting planets. We find 178 Kepler M-star targets
with rotation periods, P_rot, of < 2 days, and 110 with P_rot < 1 day. Some 30
of the 178 systems exhibit two or more independent short periods within the
same Kepler photometric aperture, while several have three or more short
periods. Adaptive optics imaging and modeling of the Kepler pixel response
function for a subset of our sample support the conclusion that the targets
with multiple periods are highly likely to be relatively young physical binary,
triple, and even quadruple M star systems. We explore in detail the one object
with four incommensurate periods all less than 1.2 days, and show that two of
the periods arise from one of a close pair of stars, while the other two arise
from the second star, which itself is probably a visual binary. If most of
these M-star systems with multiple periods turn out to be bound M stars, this
could prove a valuable way of discovering young hierarchical M-star systems;
the same approach may also be applicable to G and K stars. The ~5% occurrence
rate of rapid rotation among the ~3900 M star targets is consistent with spin
evolution models that include an initial contraction phase followed by magnetic
braking, wherein a typical M star can spend several hundred Myr before spinning
down to periods longer than 2 days.Comment: 17 pages, 12 figures, 2 tables; accepted for publication in The
Astrophysical Journa
Lattice Boltzmann simulations of lamellar and droplet phases
Lattice Boltzmann simulations are used to investigate spinodal decomposition
in a two-dimensional binary fluid with equilibrium lamellar and droplet phases.
We emphasise the importance of hydrodynamic flow to the phase separation
kinetics. For mixtures slightly asymmetric in composition the fluid phase
separates into bulk and lamellar phases with the lamellae forming distinctive
spiral structures to minimise their elastic energy.Comment: 19 pages, 5 figure
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