6,319 research outputs found
Implementable Wireless Access for B3G Networks - III: Complexity Reducing Transceiver Structures
This article presents a comprehensive overview of some of the research conducted within Mobile VCE’s Core Wireless Access Research Programme,1 a key focus of which has naturally been on MIMO transceivers. The series of articles offers a coherent view of how the work was structured and comprises a compilation of material that has been presented in detail elsewhere (see references within the article). In this article MIMO channel measurements, analysis, and modeling, which were presented previously in the first article in this series of four, are utilized to develop compact and distributed antenna arrays. Parallel activities led to research into low-complexity MIMO single-user spacetime coding techniques, as well as SISO and MIMO multi-user CDMA-based transceivers for B3G systems. As well as feeding into the industry’s in-house research program, significant extensions of this work are now in hand, within Mobile VCE’s own core activity, aiming toward securing major improvements in delivery efficiency in future wireless systems through crosslayer operation
Intra-assessor consistency in question answering
In this paper we investigate the consistency of answer assessment in a complex question answering task examining features of assessor consistency, types of answers and question type
Contextual information and assessor characteristics in complex question answering
The ciqa track investigates the role of interaction in answering complex questions: questions that relate two or more entities by some specified relationship. In our submission to the first ciqa track we were interested in the interplay between groups of variables: variables describing the question creators, the questions asked and the presentation of answers to the questions. We used two interaction forms - html questionnaires completed before answer assessment - to gain contextual information from the answer assessors to better understand what factors influence assessors when judging retrieved answers to complex questions. Our results indicate the importance of understanding the assessor's personal relationship to the question - their existing topical knowledge for example - and also the presentation of the answers - contextual information about the answer to aid in the assessment of the answer
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A case study of sea breeze blocking regulated by sea surface temperature along the English south coast
The sensitivity of sea breeze structure to sea surface temperature (SST) and coastal orography is investigated in convection-permitting Met Office Unified Model simulations of a case study along the south coast of England. Changes in SST of 1 K are shown to significantly modify the structure of the sea breeze immediately offshore. On the day of the case study, the sea breeze was partially blocked by coastal orography, particularly within Lyme Bay. The extent to which the flow is blocked depends strongly on the static stability of the marine boundary layer. In experiments with colder SST, the marine boundary layer is more stable, and the degree of blocking is more pronounced. Although a colder SST would also imply a larger land–sea temperature contrast and hence a stronger onshore wind – an effect which alone would discourage blocking – the increased static stability exerts a dominant control over whether blocking takes place. The implications of prescribing fixed SST from climatology in numerical weather prediction model forecasts of the sea breeze are discussed
Environmental monitoring of Mycobacterium bovis in badger feces and badger sett soil by real-time PCR, as confirmed by immunofluorescence, immunocapture, and cultivation
Real-time PCR was used to detect and quantify Mycobacterium bovis cells in
naturally infected soil and badger faeces. Immunomagnetic capture,
immunofluorescence and selective culture confirmed species identification and cell
viability. These techniques will prove useful for monitoring M. bovis in the
environment and for elucidating transmission routes between wildlife and cattle
Performance of an environmental test to detect Mycobacterium bovis infection in badger social groups
A study by Courtenay and others (2006) demonstrated that
the probability of detecting Mycobacterium bovis by PCR in
soil samples from the spoil heaps of main badger setts correlated
with the prevalence of excretion (infectiousness) of
captured badgers belonging to the social group. It has been
proposed that such a test could be used to target badger culling
to setts containing infectious animals (Anon 2007). This
short communication discusses the issues surrounding this
concept, with the intention of dispelling any misconceptions
among relevant stakeholders (farmers, policy makers and
conservationists)
Myeloid conditioning with c-kit-targeted CAR-T cells enables donor stem cell engraftment
We report a novel approach to bone marrow (BM) conditioning using c-kit-targeted chimeric antigen receptor T (c-kit CAR-T) cells in mice. Previous reports using anti-c-kit or anti-CD45 antibody linked to a toxin such as saporin have been promising. We developed a distinctly different approach using c-kit CAR-T cells. Initial studies demonstrated in vitro killing of hematopoietic stem cells by c-kit CAR-T cells but poor expansion in vivo and poor migration of CAR-T cells into BM. Pre-treatment of recipient mice with low-dose cyclophosphamide (125 mg/kg) together with CXCR4 transduction in the CAR-T cells enhanced trafficking to and expansion in BM (\u3c1%-13.1%). This resulted in significant depletion of the BM c-ki
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