802 research outputs found
Social class, habitus and reflexivity: an analysis of trainee teachers’ understandings
This thesis examines the relationship between trainee teachers’ social class backgrounds
and their early professional identity development in placement schools. Reasons why they
seek to train in specific schools and how trainees’ social class backgrounds affect their
choice of placement schools is explored.
The concepts of dispositional understanding and habitus are used to develop an
understanding of the social class values trainee teachers bring to an initial teacher training
course and consequently, how these concepts are made manifest during training
placements.
My epistemological position as a qualitative researcher defines the framework for how I
gather and interpret my data. Using interviews that explore social backgrounds and details
of placement experiences provides data that is rich in personal detail, as well as giving
insight into how trainees perceive their training placements and early career professional
identity development.
The findings indicate that trainees research their school-based placements in order to
ensure that they have an increased chance of successfully completing their training. This
leads to trainees preferring placements in what they perceive to be successful schools.
Making such choices reduces the potential for failure through coming into contact with
school students who may, through the trainees’ perceptions of such students, disrupt
trainees’ progress. In doing so, they seek to detach themselves from students whom they
perceive may damage their chances of successfully completing placements and ultimately,
their entry into teaching. Analysis of trainees’ recall of taught elements of their training
reveals that they privilege information relating to ethnicity, race, gender or religion over
students’ socio-economic status. Finally, analysis of policy shows that with future changes
to initial teacher training there are implications for courses due to elimination and
recruitment to schools in areas of social deprivation
Judges Are Not ‘Super-Referees’: Why a Qualified Statutory Exemption to the Sherman Act is Needed to Reform the NCAA and its Exploitive Amateur Model, 49 J. Marshall L. Rev. 125 (2015)
This Comment will analyze the historical application of antitrust laws to the rules and regulations of the NCAA and argue that, in light of a recent shift in judicial treatment, the next round of antitrust litigation threatens to destroy the entire NCAA model
Understanding the shared experiences of creating a digital life story with individuals with dementia and their spouse
IntroductionLife story books in dementia are used as a part of person-centred care. Whilst the current literature demonstrates associations between completing life story books and increased well-being, little is known about the process and how it is experienced by individuals living with dementia. Life stories are often created with a loved one, such as a partner or spouse; however, further research is required to explore experiences of life story work as a shared endeavour. Furthermore, the use of technology to create life stories is growing, with little known about how digital elements are experienced. This study aimed to understand these gaps by exploring the shared experiences of individuals with dementia and their partner/spouse creating a digital life story book.Design and MethodsFour couples participated in the six-week creation of their digital life story book. Following this, qualitative data relating to couples’ experiences were collected via semi-structured interviews.FindingsThematic analysis was used to interpret data and identified four superordinate themes relating to the shared experiences of creating their digital life story book: ‘Creating a life story book is a huge undertaking’, ‘Looking back and looking forward: The emotional journey’, ‘Whose story is it and who does it belong to?’ and ‘Challenges of using technology to build the life story book’.ConclusionsOverall, this study demonstrated that creating a digital life story was a positive experience that can support couples’ well-being, but we should not underestimate the time it will take and range of emotions experienced. The experience of using technology varied, emphasising that we must be mindful of individual preferences before considering a digital approach
MyPathway human epidermal growth factor receptor 2 basket study: Pertuzumab + trastuzumab treatment of a tissue-agnostic cohort of patients with human epidermal growth factor receptor 2-altered advanced solid tumors
Impact of alloy disorder on the band structure of compressively strained GaBiAs
The incorporation of bismuth (Bi) in GaAs results in a large reduction of the
band gap energy (E) accompanied with a large increase in the spin-orbit
splitting energy (), leading to the condition that
which is anticipated to reduce so-called CHSH Auger
recombination losses whereby the energy and momentum of a recombining
electron-hole pair is given to a second hole which is excited into the
spin-orbit band. We theoretically investigate the electronic structure of
experimentally grown GaBiAs samples on (100) GaAs substrates by
directly comparing our data with room temperature photo-modulated reflectance
(PR) measurements. Our atomistic theoretical calculations, in agreement with
the PR measurements, confirm that E is equal to for
9. We then theoretically probe the inhomogeneous
broadening of the interband transition energies as a function of the alloy
disorder. The broadening associated with spin-split-off transitions arises from
conventional alloy effects, while the behaviour of the heavy-hole transitions
can be well described using a valence band-anticrossing model. We show that for
the samples containing 8.5% and 10.4% Bi the difficulty in identifying a clear
light-hole-related transition energy from the measured PR data is due to the
significant broadening of the host matrix light-hole states as a result of the
presence of a large number of Bi resonant states in the same energy range and
disorder in the alloy. We further provide quantitative estimates of the impact
of supercell size and the assumed random distribution of Bi atoms on the
interband transition energies in GaBiAs. Our calculations support
a type-I band alignment at the GaBiAs/GaAs interface, consistent
with recent experimental findings
Advancing Prostate Cancer and Germ Cell Tumour Knowledge with Clinical and Translational Research
Being a medical oncologist provides unique insights into the limitations encountered when treating patients with cancer but also provides the opportunities to identify possible strategies to decrease the burden of cancer. However, to develop new interventions requires rigorous multidisciplinary research. In this thesis by publication, the details of six research themes are presented which have stemmed from observations derived from caring for patients with prostate cancer and germ cell tumours. This body of work emanated from the inspiration I gained from the patients fighting cancer and clinicians providing compassionate care. It became abundantly clear during my training that research spanning laboratory-based discovery science to clinical research to epidemiological studies have lead to advances for some but not all patients. Moreover, it was apparent that teamscience was critical to harness all the expertise needed to make these advances. To that end, since commencing my clinical and laboratory research training as an advanced trainee in Medical Oncology in 1997, I have been a part of, and later, lead research teams on the quest to improve the outcomes of patients with cancer. More specifically, I have devoted approximately 60% of my time to clinical care delivery for patients with cancer which included caring for patients on phase 1 to phase 3 clinical trials. The other 40% of my time was devoted to research and teaching activities which included designing, conducting and reporting on the results of investigator initiated clinical trials, building clinical data registries and biorepositories which have generated novel clinical, pathological and genomic findings. I have also lead multiple bench-top translational laboratory research projects. For the latter, I had my own laboratory at Indiana University while at Dana-Farber Cancer Institute I funded and supervised postdoctoral researchers in the laboratories of collaborators. My leadership skills and collaborative spirit have been critical in bringing the teams together to perform the research in both the clinic and the laboratory. In brief, research led by me has resulted in new insights into cancer biology as well as improved therapies and prognostic stratifications of patients with prostate and testicular cancer. This work has been funded by national peer-reviewed funding bodies (NIH, DOD, and foundation grants). The most notable completed investigator-sponsored phase 3 clinical trials led by me include two trials that have led to improvements in prostate cancer care (CHAARTED and ENZAMET) and were both published in the New England Journal of Medicine. My work has also led to unique insights regarding germ cell tumours including clinical outcomes and biological findings. Detailed in the body of this thesis are the key elements of the six research themes which highlight the major contributions from my research. The summaries detail: (i) the clinical context guiding the research contribution, (ii) the key collaborators, mentors and mentees that enabled the research and (iii) the reprints of key publications that serve as exemplars of the research findings. The six research themes are: 1. Conduct of investigator sponsored clinical trials leading to improvements in prostate cancer therapy. 2. Conduct of biomarker analysis leading to improved understanding of prostate cancer clinical outcomes. 3. Evaluation of intermediate clinical endpoints in prostate cancer as robust surrogates of overall survival 4. Leadership of randomized phase 3 industry sponsored clinical trials that have informed prostate cancer biology and prostate cancer care. 5. Development of a nuclear factor kappa B inhibitor from bench to bedside. 6. Clinical and translational research providing unique insights into germ cell tumour clinical outcomes and biology.Thesis (D.HlthSc) -- University of Adelaide, South Australian Immunogenomics Cancer Institute (SAiGENCI), 202
Rational Categorization of the Pipeline of New Treatments for Advanced Cancer – Prostate Cancer as an Example
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